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Campbell Laboratory

Research interests

I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility.

At the Centre for Neuroendocrinology I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.

Current and proposed projects:

  • Exploring the neuroendocrine mechanisms of PCOS
  • Mechanisms of pulse generation in the GnRH neuronal network
  • Steroid induced structural plasticity within the GnRH neuronal network

Clinical conditions

  • Infertility
  • Polycystic ovarian syndrome
  • Ciliopathies

Associate Professor Rebecca Campbell's researcher profile

List of publications for Rebecca Campbell (Google Scholar)

Campbell Laboratory staff & students

Chris Coyle_webChris Coyle, Postdoctoral Fellow
Androgen excess and the female brain
Email chris.coyle@otago.ac.nz

Elodie Desroziers_webElodie Desroziers, Postdoctoral Fellow
Arcuate nucleus GABA neurons in PCOS
Email elodie.desroziers@otago.ac.nz

Chris Marshall_webChris Marshall, PhD Student
Email chris.marshall@postgrad.otago.ac.nz

Mel Prescott_webMel Prescott, Assistant Research Fellow
Role of the brain in PCOS
Email mel.prescott@otago.ac.nz

Amy Ruddenklau_webAmy Ruddenklau, PhD student
Investigating the role of central progesterone signalling in PCOS
Email rudam430@student.otago.ac.nz

Aisha Sati_webAisha Sati, PhD student
Investigating the relationship between androgen excess and microglia in the female brain
Email satai881@student.otago.ac.nz

Sarah Holland, Masters student
Perinatal androgen excess effects on male offspring


Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Campbell, R. E. (2018). Morphology of the adult GnRH neuron. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 121-142). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

Moore, A. M., Abbott, G., Mair, J., Prescott, M., & Campbell, R. E. (2018). Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12657

Moore, A. M., Prescott, M., Czieselsky, K., Desroziers, E., Yip, S. H., Campbell, R. E., & Herbison, A. E. (2018). Synaptic innervation of the GnRH neuron distal dendron in female mice. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00505

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569

Chapter in Book - Research

Campbell, R. E. (2018). Morphology of the adult GnRH neuron. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 121-142). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

Clarke, I. J., Campbell, R., Smith, J. T., Prevot, V., & Wray, S. (2012). Neuroendocrine control of reproduction. In G. Fink, D. W. Pfaff & J. Levine (Eds.), Handbook of Neuroendocrinology. (pp. 197-235). Elsevier. doi: 10.1016/b978-0-12-375097-6.10009-5

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Journal - Research Article

Moore, A. M., Abbott, G., Mair, J., Prescott, M., & Campbell, R. E. (2018). Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12657

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Moore, A. M., Prescott, M., Czieselsky, K., Desroziers, E., Yip, S. H., Campbell, R. E., & Herbison, A. E. (2018). Synaptic innervation of the GnRH neuron distal dendron in female mice. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00505

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Moore, A. M., & Campbell, R. E. (2017). Polycystic ovary syndrome: Understanding the role of the brain. Frontiers in Neuroendocrinology, 46, 1-14. doi: 10.1016/j.yfrne.2017.05.002

Marshall, C. J., Desroziers, E., McLennan, T., & Campbell, R. E. (2017). Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice. Neuroendocrinology, 105(2), 157-169. doi: 10.1159/000452105

Kunovac-Kallak, T., Hellgren, C., Skalkidou, A., Sandelin-Francke, L., Ubhayasekhera, K., Bergquist, J., … Campbell, R. E., & Sundström Poromaa, I. (2017). Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain. European Journal of Endocrinology, 177, 379-388. doi: 10.1530/eje-17-0207

Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S. P., … Prescott, M., Campbell, R., Herbison, A. E., … Giacobini, P. (2016). Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nature Communications, 7, 10055. doi: 10.1038/ncomms10055

Moore, A. M., & Campbell, R. E. (2016). The neuroendocrine genesis of polycystic ovary syndrome: A role for arcuate nucleus GABA neurons. Journal of Steroid Biochemistry & Molecular Biology, 160, 106-117. doi: 10.1016/j.jsbmb.2015.10.002

Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351

Moore, A. M., Prescott, M., Marshall, C. J., Yip, S. H., & Campbell, R. E. (2015). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. PNAS, 112(2), 596-601. doi: 10.1073/pnas.1415038112

Yip, S. H., Boehm, U., Herbison, A. E., & Campbell, R. E. (2015). Conditional viral tract tracing delineates the projections of the distinct kisspeptin neuron populations to gonadotropin-releasing hormone (GnRH) neurons in the mouse. Endocrinology, 156(7), 2582-2594. doi: 10.1210/en.2015-1131

Campbell, R. E., & Herbison, A. E. (2014). Gonadal steroid neuromodulation of developing and mature hypothalamic neuronal networks. Current Opinion in Neurobiology, 29, 96-102. doi: 10.1016/j.conb.2014.06.003

Shin, J., Prescott, M., Mair, J., & Campbell, R. E. (2014). Roles for primary cilia in gonadotropin-releasing hormone neurons in the mouse. Journal of Neuroendocrinology, 26(1), 18-25. doi: 10.1111/jne.12122

Moore, A. M., Prescott, M., & Campbell, R. E. (2013). Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology, 154(2), 796-806. doi: 10.1210/en.2012-1954

Norberg, R., Campbell, R., & Suter, K. J. (2013). Ion channels and information processing in GnRH neuron dendrites. Channels, 7(3), 135-145. doi: 10.4161/chan.24228

Campbell, R. E., Ducret, E., Porteous, R., Liu, X., Herde, M. K., Wellerhaus, K., … Herbison, A. E. (2011). Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology, 152(6), 2290-2301. doi: 10.1210/en.2010-1311

Herde, M. K., Geist, K., Campbell, R. E., & Herbison, A. E. (2011). Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology, 152(10), 3832-3841. doi: 10.1210/en.2011-1228

Chan, H., Prescott, M., Ong, Z. Y., Herde, M. K., Herbison, A. E., & Campbell, R. E. (2011). Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology, 152(12), 4906-4914. doi: 10.1210/en.2011-1522

Lee, K., Porteous, R., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010). Knockdown of GABAA receptor signaling in GnRH neurons has minimal effects upon fertility. Endocrinology, 151(9), 4428-4436. doi: 10.1210/en.2010-0314

Campbell, R. E., & Suter, K. J. (2010). Redefining the gonadotrophin-releasing hormone neurone dendrite. Journal of Neuroendocrinology, 22, 650-658. doi: 10.1111/j.1365-2826.2010.02032.x

Campbell, R. E., Gaidamaka, G., Han, S.-K., & Herbison, A. E. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. PNAS, 106(26), 10835-10840. doi: 10.1073/pnas.0903463106

Roberts, C. B., Campbell, R. E., Herbison, A. E., & Suter, K. J. (2008). Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons. Endocrinology, 149(7), 3355-3360.

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