I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility.
At the Centre for Neuroendocrinology I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.
Current and proposed projects:
- Exploring the neuroendocrine mechanisms of PCOS
- Mechanisms of pulse generation in the GnRH neuronal network
- Steroid induced structural plasticity within the GnRH neuronal network
- Polycystic ovarian syndrome
Campbell Laboratory staff & students
Chris Coyle, Postdoctoral Fellow
Androgen excess and the female brain
Kay Potapov, Assistant Research Fellow
Mel Prescott, Assistant Research Fellow
Role of the brain in PCOS
Amy Ruddenklau, PhD student
Investigating the role of central progesterone signalling in PCOS
Aisha Sati, PhD student
Investigating the relationship between androgen excess and microglia in the female brain
Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.
Sati, A., Prescott, M., Holland, S., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). Morphological evidence indicate a role for microglia in shaping the polycystic ovary syndrome (PCOS)-like brain. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12999
Sati, A., Prescott, M., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). The role of microglia in the polycystic ovary syndrome (PCOS)-like brain. Journal of the Endocrine Society, 5(Suppl. 1), (pp. A556). doi: 10.1210/jendso/bvab048.1133
Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972
Jamieson, B. B., Bouwer, G. T., Campbell, R. E., & Piet, R. (2021). Estrous cycle plasticity in the central clock output to kisspeptin neurons: Implications for the preovulatory surge. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqab071
Sucquart, I. E., Nagarkar, R., Edwards, M. C., Paris, V. R., Aflatounian, A., Bertoldo, M. J., Campbell, R. E., … Walters, K. A. (2021). Neurokinin 3 receptor antagonism ameliorates key metabolic features in a hyperandrogenic PCOS mouse model. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqab020