I am interested in how the changing hormones of pregnancy and lactation act on neural circuitry in the maternal brain to influence behaviour. In particular, I focus on maternal behaviour, a complex set of behaviours displayed by a mother that promote the survival and wellbeing of her offspring. Our work aims to understand how hormones normally act to direct a mother’s behaviour and how these processes may become disrupted.
At the Centre for Neuroendocrinology, I use transgenic mouse models to address the impact of specific neuroendocrine disruptions on maternal behaviour using behavioural assays. We investigate hormonal actions on neural circuitry underlying parental behaviour using a range of molecular, immunohistochemical and imaging approaches.
I am also interested in how changes in the ability of hormones to access the brain in different physiological or pathological states might underlie changes in hormone function.
Rosie Brown Laboratory staff & students
Isaiah Cheong, Assistant Research Fellow
Neuroendocrine regulation of maternal behaviour
Jenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy
Jamie McQuillan, Postdoctoral Fellow
Tapasya Pal, Postdoctoral Fellow
Michael Perkinson, Postdoctoral Fellow
Alice Biggs, B Biomed Sci student
Matthew Adye, B Biomed Sci student
Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2022). Pups and prolactin are rewarding to virgin female and pregnant mice. Journal of Neuroendocrinology, e13232. Advance online publication. doi: 10.1111/jne.13232
Khant Aung, Z., Masih, R. R., Desroziers, E., Campbell, R. E., & Brown, R. S. E. (2022). Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13206
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2022). Prolactin action is necessary for parental behavior in male mice. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.0558-22.2022
Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. PNAS, 119(6), e2116972119. doi: 10.1073/pnas.2116972119
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041