Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Pharmacy staff profile

Associate Professor Arlene McDowell

PositionAssociate Professor
QualificationsMSc PhD
Research summaryVeterinary pharmaceutics and delivery of bioactives

Research

  • Drug delivery for veterinary species and the application of pharmaceutical formulation for wildlife applications
  • Assessment and formulation of antioxidant phytochemicals

Current projects:

  • Polymeric nanoparticles for delivery of peptides and proteins
  • Oral delivery of biocontrol agents to the brushtail possum
  • In vivo evaluation of formulations
  • Delivery of anesthetics to laboratory animals
  • Pre-formulation of antioxidant phytochemicals

McDowell Lab Group website

Publications

Rooney, J. S., McDowell, A., Strachan, C. J., & Gordon, K. C. (2015). Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines. Talanta, 138, 77-85. doi: 10.1016/j.talanta.2015.02.016

Chiu, J. Z. S., Tucker, I. G., McLeod, B. J., & McDowell, A. (2015). Arginine-tagging of polymeric nanoparticles via histidine to improve cellular uptake. European Journal of Pharmaceutics & Biopharmaceutics, 89, 48-55. doi: 10.1016/j.ejpb.2014.11.014

Ou, Z.-Q., Schmierer, D. M., Rades, T., Larsen, L., & McDowell, A. (2013). Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts. Journal of Pharmacy & Pharmacology, 65(2), 271-279. doi: 10.1111/j.2042-7158.2012.01591.x

Kafka, A. P., McLeod, B. J., Rades, T., & McDowell, A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. Journal of Controlled Release, 149(3), 307-313. doi: 10.1016/j.jconrel.2010.10.029

McDowell, A., Assink, L., Musgrave, R., Soper, H., Norris, P., & Williams, C. (2011). Comparison of prescribing and dispensing processes between veterinarians and pharmacists in New Zealand: Are there opportunities for cooperation? Pharmacy Practice, 9(1), 23-30.

Rooney, J. S., McDowell, A., Strachan, C. J., & Gordon, K. C. (2015). Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines. Talanta, 138, 77-85. doi: 10.1016/j.talanta.2015.02.016

Journal - Research Article

Chiu, J. Z. S., Tucker, I. G., McLeod, B. J., & McDowell, A. (2015). Arginine-tagging of polymeric nanoparticles via histidine to improve cellular uptake. European Journal of Pharmaceutics & Biopharmaceutics, 89, 48-55. doi: 10.1016/j.ejpb.2014.11.014

Journal - Research Article

Ou, Z.-Q., Schmierer, D. M., Rades, T., Larsen, L., & McDowell, A. (2013). Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts. Journal of Pharmacy & Pharmacology, 65(2), 271-279. doi: 10.1111/j.2042-7158.2012.01591.x

Journal - Research Article

Kafka, A. P., McLeod, B. J., Rades, T., & McDowell, A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. Journal of Controlled Release, 149(3), 307-313. doi: 10.1016/j.jconrel.2010.10.029

Journal - Research Article

McDowell, A., Assink, L., Musgrave, R., Soper, H., Norris, P., & Williams, C. (2011). Comparison of prescribing and dispensing processes between veterinarians and pharmacists in New Zealand: Are there opportunities for cooperation? Pharmacy Practice, 9(1), 23-30.

Journal - Research Article

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2009). Histidine residues in the peptide D-Lys6-GnRH: Potential for copolymerization in polymeric nanoparticles. Molecular Pharmaceutics, 6(5), 1483-1491. doi: 10.1021/mp900043e

Journal - Research Article

McDowell, A., Thompson, S., Stark, M., Ou, Z.-Q., & Gould, K. S. (2011). Antioxidant activity of puha (Sonchus oleraceus L.) as assessed by the cellular antioxidant activity (CAA) assay. Phytotherapy Research, 25(12), 1876-1882. doi: 10.1002/ptr.3648

Journal - Research Article

McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2006). Application of pharmaceutical drug delivery for biological control of the common brushtail possum in New Zealand: A review. Wildlife Research, 33, 679-689.

Journal - Research Article

McDowell, A. (2013). Delivery systems for wildlife. In M. J. Rathbone & A. McDowell (Eds.), Long acting animal health drug products: Fundamentals and applications. (pp. 345-357). New York: Springer. doi: 10.1007/978-1-4614-4439-8_15

Chapter in Book - Research

Graf, A., McDowell, A., & Rades, T. (2009). Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics: Is there real potential? Expert Opinion on Drug Delivery, 6(4), 371-387. doi: 10.1517/17425240902870413

Journal - Research Article

Ou, Z.-Q., Schmierer, D. M., Strachan, C. J., Rades, T., & McDowell, A. (2014). Influence of postharvest processing and storage conditions on key antioxidants in pūhā (Sonchus oleraceus L.). Journal of Pharmacy & Pharmacology, 66, 998-1008. doi: 10.1111/jphp.12220

Journal - Research Article

Kafka, A. P., Rades, T., & McDowell, A. (2010). Rapid and specific high-performance liquid chromatography for the in vitro quantification of D-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products. Biomedical Chromatography, 24(2), 132-139. doi: 10.1002/bmc.1261

Journal - Research Article

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215.

Journal - Research Article

Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2011). The application of MALDI TOF MS in biopharmaceutical research. International Journal of Pharmaceutics, 417(1-2), 70-82. doi: 10.1016/j.ijpharm.2010.12.010

Journal - Research Article

Krittaphol, W., McDowell, A., Thomson, C. D., Tucker, I. G., Fawcett, J. P., & Mikov, M. (2009). An improved HPLC method for the investigation of L-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174. doi: 10.1002/bmc.1239

Journal - Research Article

McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2009). Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57(6), 370-377.

Journal - Research Article

McDowell, A., & McLeod, B. J. (2007). Physiology and pharmacology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract. Advanced Drug Delivery Reviews, 59, 1121-1132.

Journal - Research Other

McDowell, A., Fothergill, J. A., Khan, A., & Medlicott, N. J. (2014). A cyclodextrin formulation to improve use of the anesthetic tribromoethanol (Avertin®). Journal of Pharmacy & BioAllied Sciences, 6(1), 16-21. doi: 10.4103/0975-7406.124303

Journal - Research Article

Krittaphol, W., Wescombe, P. A., Thomson, C. D., McDowell, A., Tagg, J. R., & Fawcett, J. P. (2011). Metabolism of L-selenomethionine and selenite by probiotic bacteria: In vitro and in vivo studies. Biological Trace Element Research, 144, 1358-1369. doi: 10.1007/s12011-011-9057-2

Journal - Research Article

More publications...