Contact Details
University Links
- Position
- PhD Student
- Department
- Department of Physiology
- Qualifications
- BSc(Hons)
- Research summary
- Investigating if fructose could also effect the pancreatic beta cells
Research
Diabetes Mellitus afflicts more than 400 million people worldwide, but the enigmatic causes has slowed the progress of treatment. Type 2 Diabetes Mellitus accounts for 90% of all cases, and is characterised by insulin resistance and pancreatic beta cell dysfunction.
Fructose is a sugar which has been consumed more and more (i.e. high fructose corn syrup) over the past 50 years, in parallel with the rising diabetes and obesity rates. When fructose is metabolised, the reaction causes an increase in production of uric acid, which has been shown to have direct effects on insulin resistance in the liver. Could fructose also effect the pancreatic beta cells?
Publications
Lyth, D. (2025, September). Circular RNA as markers of pancreatic β-cell mass. Verbal presentation at the 19th New Zealand Medical Sciences Congress (MedSci), Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Lyth, D., & Leask, M. (2025). Gouty inflammation: Genetic mechanisms towards flare therapy. Current Opinion in Rheumatology. Advance online publication. doi: 10.1097/bor.0000000000001119 Journal - Research Other
Lyth, D. D. B., Lamberts, R. R., & Bahn, A. (2024, August-September). Circular RNA as markers of pancreatic ß-cell mass. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Lyth, D. D. B., Ware, A. W., & Bahn, A. (2023, August). Linking hyperuricemia and the TGF-beta pathway in breast cancer. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Lyth, D., Ware, A., & Bahn, A. (2022, August-September). Does hyperuricemia drive breast cancer metastasis via changes in TGFβ signalling? Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)