Contact Details
University Links
- Position
- Teaching Fellow
- Department
- Department of Physiology
- Iwi affiliations
- Ngāti Rāhiri Tumutumu
- Qualifications
- BSc(Hons) MSc
- Research summary
- Calcium-activated potassium channels
- Teaching
- 100-, 200-, and 300-level Physiology papers and related courses
- Memberships
- American Physiological Society
- Dunedin Company of Physiologists
- Physiological Society of New Zealand
Research
My primary research interests focus on ion channel regulation and physiology, with a particular emphasis on the calcium-activated family of potassium channels.
My research also extends to understanding protein trafficking pathways; exploring how membrane-bound proteins—particularly ion channels—are transported to their correct cellular destinations, as well as the implications of trafficking defects in pathological conditions, such as cystic fibrosis (CF).
In my research, I make use of a variety of protein-based biochemical assays, Ussing chamber eletrophysiology, and fluorescence imaging techniques to answer fundamental questions about the trafficking pathways and regulation of ion channels.
Publications
Scott, M. L., Cheung, T. T., Logue, M. J. E., Zheng, F., Hamilton, K. L., & McDonald, F. J. (2025). Sorting nexins associated with recycling complexes regulate epithelial sodium channel trafficking. American Journal of Physiology: Renal Physiology. Advance online publication. doi: 10.1152/ajprenal.00088.2025 Journal - Research Article
Logue, M. J. E., Farquhar, R. E., Eckhoff-Björngard, Y., Cheung, T. T., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2023). The exocyst complex is required for the trafficking and delivery of KCa3.1 to the basolateral membrane of polarized epithelia. American Journal of Physiology: Cell Physiology, 324, C1249-C1262. doi: 10.1152/ajpcell.00374.2022 Journal - Research Article
Farquhar, R. E., Cheung, T. T., Logue, M. J. E., McDonald, F. J., Devor, D. C., & Hamilton, K. L. (2022). Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium. Frontiers in Physiology, 13, 905834. doi: 10.3389/fphys.2022.905834 Journal - Research Article
Logue, M. J. E., Devor, D. C., McDonald, F. J., & Hamilton, K. L. (2024). Retromer- and retriever-associated sorting nexins regulate traffcking of KCa2.3 channels. Physiology, 39(Suppl. 1). doi: 10.1152/physiol.2024.39.S1.386 Conference Contribution - Published proceedings: Abstract
Hamilton, K., Logue, M., Chueng, T., Pilmore, E., Devor, D., & McDonald, F. (2023). Retromer involvement in trafficking of the calcium-activated K channel, KCa3.1. Physiology, 38(Suppl. 1). doi: 10.1152/physiol.2023.38.S1.5733913 Conference Contribution - Published proceedings: Abstract