Contact Details
University Links
- Position
- PhD Student
- Department
- Department of Physiology
- Qualifications
- BSc
- Research summary
- Gout flares have been shown to be in a functional relationship with circadian rhythm
Research
Gout flares have been shown to be in a functional relationship with circadian rhythm, with those diagnosed with gout being more likely to experience a gout flare at night than during the day. My project aims to genetically link the two through investigation of single-nucleotide polymorphisms in non-coding enhancer elements highlighted from genome-wide association studies conducted in both pan-population cohorts and in Māori/Pacific-specific populations. Utilising zebrafish as a model organism, I leverage behavioural analyses and fluorescent imaging data to draw conclusions on how these non-coding enhancer elements impact the relationship between gout flares and circadian rhythm function.
Publications
Darroch, H., Mosimann, C., Lalonde, R., Calhoun, C., Morice, E., Ledgerwood, E., … Stamp, L., Merriman, T., Horsfield, J., Wilcox, P., & Leask, M. (2024, August-September). Novel ‘omics and molecular pipelines in zebrafish for precision medicine for and by Māori. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Leask, M., Darroch, H., Morice, E., Calhoun, C., Wilcox, P., Horsfield, J., & Merriman, T. (2024). Beyond GWAS and towards precision medicine equity for Indigenous populations. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract