Determining the functional effect of phosphorylated Calsequestrin Type II
Dr Michelle Munro
Our lab investigates how changes in cardiomyocyte organisation influence function in cardiac arrhythmia and heart failure.
How CSQ2 glycosylation influences heart failure and arrhythmia
Dr Helen Waddell
How structural changes of cardiomyocytes contribute to atrial fibrillation and arrhythmia
I am interested in how the cardiac ultrastructure impacts the function of the heart, in particular the organisation of specialised structures known as the dyad and transverse tubules. I am investigating how these structures are remodelled in atrial fibrillation and heart failure, and whether specific proteins can be targeted to restore cardiac organisation and function in heart disease.
- Restoration of calcium balance by calsequestrin in atrial fibrillation
- 2019–2022: Heart Foundation of New Zealand Research Fellowship
- 2020–2022: Health Research Council Emerging Researcher First Grant
- Heart Foundation of New Zealand small project grant
Waddell, H. M. M., Mereacre, V., Alvarado, F. J., & Munro, M. L. (2023). Clustering properties of the cardiac ryanodine receptor in health and heart failure. Journal of Molecular & Cellular Cardiology, 185, 38-49. doi: 10.1016/j.yjmcc.2023.10.012
Okolo, C. A., Khaing, E.-P., Mereacre, V., Wallace, R. S., Munro, M. L., Erickson, J. R., & Jones, P. P. (2023). Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation. Cardiovascular Diabetology, 22, 276. doi: 10.1186/s12933-023-02010-3
Waddell, H., de Jonge, W., & Munro, M. (2023). Preparation of functional human atrial slices and multi-day tissue culture. Heart, Lung & Circulation, 32(Suppl. 3), 680. doi: 10.1016/j.hlc.2023.06.584
Keelty, G. B., de Jonge, W. M., Waddell, H. M. M., & Munro, M. L. (2023). Characterizing transverse tubules in the right atrium of arrhythmic patients. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Munro, M. (2022, June). Biphasic regulation of RyR2 activity by calsequestrin-2: Implications in Ca-mediated arrhythmias. Invited presentation at the XXIV World Congress of the International Society for Heart Research (ISHR), Berlin, Germany.