My research focuses on investigating the mechanisms that underlie heart failure and vascular disease particularly in the context of hypertension and diabetes. To this end, we have developed a number of novel tools to assess cardiovascular signaling pathways.
These include:
FRET-based biosensors to measure kinase activity and localization in living cells
Custom antibodies to measure biochemical modifications of proteins
A variety of animal models with enhanced or reduced susceptibility to cardiovascular pathology.
With this research, we hope to contribute new understanding to the molecular basis of cardiovascular signaling that will culminate in potential clinical therapies for heart disease and atherosclerosis.
Projects
Identifying the mechanism by which CaMKII regulates cellular signaling in the diabetic heart
The role of CaMKII in vascular physiology and pathology
Nitric oxide as a mediator of cardiac signaling
Current funding
Health Research Council Project Grant
Royal Society of New Zealand Marsden Fast Start Research Grant
University of Otago Research Grant
Previous funding
American Heart Association Scientist Development Grant
Power, A. S., Asamudo, E. U., Worthington, L. P. I., Alim, C. C., Parackal, R. E., Wallace, R. S., Ebenebe, O. V., … Erickson, J. R. (2023). Nitric oxide modulates Ca2+ leak and arrhythmias via S-nitrosylation of CaMKII. Circulation Research, 133, 1040-1055. doi: 10.1161/circresaha.123.323571
Journal - Research Article
Okolo, C. A., Khaing, E.-P., Mereacre, V., Wallace, R. S., Munro, M. L., Erickson, J. R., & Jones, P. P. (2023). Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation. Cardiovascular Diabetology, 22, 276. doi: 10.1186/s12933-023-02010-3
Journal - Research Article
Singh, E., Chandrasekera, D., Wallace, R. S., de Jonge, W., Bunton, R., Parry, D., Davis, P., Erickson, J. R., & Katare, R. (2023, August). Impact of microRNA15b and CaMKIIδ on cardiac fibrosis in diabetes. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Giles, G. I., Erickson, J. R., & Bussey, C. T. (2022). Photoactivation of tDodSNO induces localized vasodilation in rats: Metabolically stable S-nitrosothiols can act as targeted nitric oxide donors in vivo. Nitric Oxide, 129, 53-62. doi: 10.1016/j.niox.2022.10.001
Journal - Research Article
Khaing, E. P., Okolo, C. A., Erickson, J. R., & Jones, P. P. (2022, August-September). Regulation of RyR2 by O-GlcNAcylation. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Ashley, Z., Ebenebe, O. V., Erickson, J. R., & Heather, A. K. (2022, August-September). A new scoring system to evaluate atherosclerotic lesions in female ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Roberts-Craig, F., Ashley, Z., Worthington, L. P., O'Hara, S. P., Erickson, J. R., & Heather, A. K. (2022, August-September). Lack of CaMKII is protective against atherosclerosis progression in aging ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Mitchell, B., & Erickson, J. R. (2022, August-September). Structure/function effects of CaMKIIδ ablation in the diabetic heart. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Yap, S. J. M., & Erickson, J. R. (2022, August-September). Sex differences in arrhythmias in response to nitric oxide signalling. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Veitch, C. R., & Erickson, J. R. (2022, August-September). Effects of O-GlcNAcylation in DCM: Acute modulation of O-GlcNAc in trabeculae. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Power, A., Asamudo, E., Wallace, R., & Erickson, J. (2022). Nitric oxide modulates spontaneous calcium release and ventricular arrhythmias during β-adrenergic signalling through S-nitroslyation of calcium/calmodulin dependent kinase II. Heart, Lung & Circulation, 31(Suppl. 3), (pp. S313). doi: 10.1016/j.hlc.2022.06.544
Conference Contribution - Published proceedings: Abstract
Roberts-Craig, F. T., Worthington, L. P., O'Hara, S. P., Erickson, J. R., Heather, A. K., & Ashley, Z. (2022). CaMKII splice variants in vascular smooth muscle cells: The next step or redundancy? International Journal of Molecular Sciences, 23, 7916. doi: 10.3390/ijms23147916
Journal - Research Other
Greenman, A. C., Diffee, G. M., Power, A. S., Wilkins, G. T., Gold, O. M. S., Erickson, J. R., & Baldi, J. C. (2022). Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats. Journal of Applied Physiology, 132, 1350-1360. doi: 10.1152/japplphysiol.00785.2021
Journal - Research Article
Asamudo, E. U., & Erickson, J. R. (2021). Acute and chronic effects of nitric oxide exposure on cardiac arrhythmias. New Zealand Medical Journal, 134(1547), (pp. 138). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Greenman, A. C., Diffee, G. M., Power, A. S., Wilkins, G. T., Gold, O. M. S., Erickson, J. R., & Baldi, J. C. (2021). Increased myofilament calcium sensitivity is associated with decreased cardiac troponin I phosphorylation in the diabetic rat heart. Experimental Physiology, 106, 2235-2247. doi: 10.1113/ep089730
Journal - Research Article
Veitch, C. R., Power, A. S., & Erickson, J. R. (2021). CaMKII inhibition is a novel therapeutic strategy to prevent diabetic cardiomyopathy. Frontiers in Pharmacology, 12, 695401. doi: 10.3389/fphar.2021.695401
Journal - Research Other
Hegyi, B., Fasoli, A., Ko, C. Y., Van, B. W., Alim, C. C., Shen, E. Y., … Erickson, J. R., … Bers, D. M. (2021). CaMKII serine 280 O-GlcNAcylation links diabetic hyperglycemia to proarrhythmia. Circulation Research, 129, 98-113. doi: 10.1161/CIRCRESAHA.120.318402
Journal - Research Article
Worthington, L. P. I., Erickson, J. R., & Heather, A. K. (2021). Calcium calmodulin dependent protein kinase II δ in the pathogenesis of atherosclerosis. New Zealand Medical Journal, 134(1537), (pp. 112). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Ng, Y. H., Okolo, C. A., Erickson, J. R., Baldi, J. C., & Jones, P. P. (2021). Protein O-GlcNAcylation in the heart. Acta Physiologica, 233, e13696. doi: 10.1111/apha.13696
Journal - Research Article
Helmstadter, K. G., Ljubojevic-Holzer, S., Wood, B. M., Taheri, K. D., Sedej, S., Erickson, J. R., … Bers, D. M. (2021). CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes. Basic Research in Cardiology, 116, 11. doi: 10.1007/s00395-021-00850-2
Journal - Research Article
Prakoso, D., Lim, S. Y., Erickson, J. R., Wallace, R. S., Lees, J. G., Tate, M., … Ritchie, R. H. (2021). Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart. Cardiovascular Research, 118, 212-225. doi: 10.1093/cvr/cvab043
Journal - Research Article
Asamudo, E., Wallace, R., Power, A., & Erickson, J. (2020). Modulation of CaMKIIδ aactivity by nitric oxide can promote or prevent ß-adrenergic-induced cardiac arrhythmias. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S140). doi: 10.1016/j.hlc.2020.09.244
Conference Contribution - Published proceedings: Abstract
Ashley, Z., Ebenebe, O., Worthington, L. P. I., Erickson, J., & Heather, A. K. (2020). Understanding the subtleties of development of atherosclerosis and the effect of sex hormones. New Zealand Medical Journal, 133(1518), (pp. 97-98). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710
Journal - Research Article
Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394
Journal - Research Article
Augustine, R., Barad, Z., Wallace, R., Erickson, J., & Brown, C. (2019). Mapping o-linked glycosylation in the brain during pregnancy. Brain & Neuroscience Advances, 3, PM102. doi: 10.1177/2398212819855490
Conference Contribution - Published proceedings: Abstract
Veitch, C. R., Aitken-Buck, H. M., & Erickson, J. R. (2019, September). The alpha-adrenergic system and CaMKII in diabetic arrhythmia. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Power, A. S., Wallace, R. S., & Erickson, J. R. (2019, September). Nitric oxide in the heart: A moderator of β-adrenergic signalling? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Greenman, A. C., Power, A. S., Erickson, J. R., & Baldi, J. C. (2019, September). Reduced calcium sensitivity occurs without differential total myofilament phosphorylation in a diabetic rat model. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Augustine, R. A., Dell, C., Wallace, R. S., Erickson, J. R., & Brown, C. H. (2019, August-September). Do mice with gestational glucose intolerance have increased O-linked glycosylation in the brain? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Asamudo, E., & Erickson, J. (2019). S-nitrosylation as a post-translational modification of CaMKIIδ and its effects on cardiac function. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S228-S229). doi: 10.1016/j.hlc.2019.06.222
Conference Contribution - Published proceedings: Abstract
Popescu, I., Yin, G., Velmurugan, S., Erickson, J. R., Despa, F., & Despa, S. (2019). Lower sarcoplasmic reticulum Ca2+ threshold for triggering afterdepolarizations in diabetic rat hearts. Heart Rhythm, 16(5), 765-772. doi: 10.1016/j.hrthm.2018.11.001
Journal - Research Article
Okolo, C. A., McLay, J. C., McLachlan, J. J., Munro, M., Tanner, C., Chakraborty, A. D., Erickson, J. R., & Jones, P. P. (2018, August). Regulation of RyR2 by O-linked glycosylation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Khan, N., Smeeton, J. H., Lamberts, R. R., & Erickson, J. R. (2018, August). Role of CaMKII and alpha-adrenergic stimulation in diabetic heart function. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Worthington, L. P. I., Erickson, J. R., Jones, G. T., & Heather, A. K. (2018, August). CaMKII inhibition as a novel target to control the early progression of atherosclerosis. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Smeeton, J. H., Khan, N. A., Bussey, C. T., Erickson, J. R., & Lamberts, R. R. (2018, August). α-adrenergic control of the diabetic heart. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Barad, Z., Augustine, R. A., Wallace, R. S., Erickson, J. R., & Brown, C. H. (2018, August). Mapping O-linked glycosylation in the brain during pregnancy. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Bussey, C. T., & Erickson, J. R. (2018). Physiology and pathology of cardiac CaMKII. Current Opinion in Physiology, 1, 52-58. doi: 10.1016/j.cophys.2017.07.003
Journal - Research Other
Greenman, A., Diffee, G., Wallace, R., Lamberts, R., Erickson, J., & Baldi, C. (2018). Reduced myofilament calcium-sensitivity occurs without phosphorylation of cTnI serine 23/24 in human diabetic cardiomyocytes. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S125). doi: 10.1016/j.hlc.2018.06.184
Conference Contribution - Published proceedings: Abstract
Bussey, C., Iremonger, R., Lamberts, R., & Erickson, J. (2018). Myocardial impairments preceding overt in vivo cardiac dysfunction are prevented by beta blockade in type 2 diabetic Zucker diabetic fatty rats. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S114). doi: 10.1016/j.hlc.2018.06.158
Conference Contribution - Published proceedings: Abstract
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Journal - Research Article
Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., … Erickson, J. R., … Delbridge, L. M. D. (2018). Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive: A new preclinical model. Journal of the American Heart Association, 7(11), e007451. doi: 10.1161/jaha.117.007451
Journal - Research Article
Ebenebe, O. V., Heather, A., & Erickson, J. R. (2018). CaMKII in vascular signalling: “Friend or foe”? Heart, Lung & Circulation, 27(5), 560-567. doi: 10.1016/j.hlc.2017.12.003
Journal - Research Other
Bussey, C. T., Wallace, R. S., Lamberts, R. R., & Erickson, J. R. (2017). Beta-blockade restores myocardial function in type 2 diabetic rats via CaMKII-independent mechanisms. Journal of Molecular & Cellular Cardiology, 109(Suppl.), (pp. 34). doi: 10.1016/j.yjmcc.2017.06.002
Conference Contribution - Published proceedings: Abstract
Bussey, C. T., Erickson, J. R., Fronius, M., & Ashley, Z. (2017, September). The role of vascular ENaC in impaired flow-mediated responses of carotid arteries in diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Worthington, L. P. I., Erickson, J. R., Jones, G. T., & Heather, A. K. (2017, September). CaMKII inhibition reduces foam cell lesion development in the brachiocephalic artery of apolipoprotein E-/- knockout mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Iremonger, R. R., Bussey, C. T., & Erickson, J. R. (2017, September). The role of beta blockers in cardiac structural remodelling. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Calverley, J. R., Erickson, J. R., & Lamberts, R. R. (2017, September). Determining the physiological importance of CaMKII in alpha-adrenergic (α-AR) regulation of heart function in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Daniels, L. J., Lamberts, R. R., McDonald, F., Pereira, L., Bers, D. M., & Erickson, J. R. (2017, September). The role of calcium calmodulin dependent protein kinase II in type 2 diabetic cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2017, September). The role of CaMKII in atherosclerotic plaque calcification in the ApoE-null mouse. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ebenebe, O., Heather, A., & Erickson, J. (2017). The role of CaMKII in atherosclerotic plaque calcification in the ApoE-null mouse. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S65). doi: 10.1016/j.hlc.2017.06.051
Conference Contribution - Published proceedings: Abstract
Cserne Szappanos, H., Erickson, J., & Hool, L. (2017). Nitric oxide potentiates the effect of calcium/calmodulin-dependent kinase II on Cav1.2 Protein. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S109). doi: 10.1016/j.hlc.2017.06.152
Conference Contribution - Published proceedings: Abstract
Bussey, C., Mugloo, S., Erickson, J., Fronius, M., & Ashley, Z. (2016, December). β-blockers rescue flow-mediated responses of carotid arteries in diabetes through a reduction in vascular ENaC activity? Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2016, August-September). 17β-Estradiol induced calcification and altered CaMKII expression in a mouse model of atherosclerosis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca2+ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Worthington, L. P., Erickson, J. R., & Heather, A. K. (2016, August-September). CaMKII mediates vascular smooth muscle cell activation central to the development of atherosclerosis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Okolo, C. A., McLachlan, J. J., McLay, J. C., Erickson, J. R., & Jones, P. P. (2016, August-September). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Daniels, L. J., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2016, August-September). The effects of CaMKII inhibition on post-rest behavior and spontaneous contractions in isolated Zucker diabetic fatty rat cardiac muscle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2016, August). 17β-Estradiol induced calcification and alters CaMKII expression in a mouse model of atherosclerosis. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Okolo, C. A., McLachlan, J. J., McLay, J., Erickson, J. R., & Jones, P. P. (2016, August). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Worthington, L. P., Erickson, J. R., & Heather, A. K. (2016, August). CaMKII activation in endothelial dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Daniels, L. J., Lamberts, R. R., McDonald, F. J., & Erickson, J. R. (2016, August). CaMKII inhibition restores contractile performance in cardiac muscle from a rat model of type 2 diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Erickson, J., Lamberts, R., & Daniels, L. (2016). CaMKII inhibition restores contractility in trabeculae from diabetic rats. Heart, Lung & Circulation, 25(Suppl. 2), (pp. S84-S85). doi: 10.1016/j.hlc.2016.06.197
Conference Contribution - Published proceedings: Abstract
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2015, August-September). The role of CaMKII activation in atheroma formation in the ApoE-null mouse. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Erickson, J. R., Nichols, C. B., Uchinoumi, H., Stein, M. L., Bossuyt, J., & Bers, D. M. (2015). S-nitrosylation induces both autonomous activation and inhibition of calcium/calmodulin-dependent protein kinase II δ. Journal of Biological Chemistry, 290(42), 25646-25656. doi: 10.1074/jbc.M115.650234
Journal - Research Article
Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3
Journal - Research Article
Grimm, M., Ling, H., Willeford, A., Pereira, L., Gray, C. B. B., Erickson, J. R., … Brown, J. H. (2015). CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular & Cellular Cardiology, 85, 282-291. doi: 10.1016/j.yjmcc.2015.06.007
Journal - Research Article
Pereira, L., Rehman, H., Lao, D. H., Erickson, J. R., Bossuyt, J., Chen, J., & Bers, D. M. (2015). Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. PNAS, 112(13), 3991-3996. doi: 10.1073/pnas.1416163112
Journal - Research Article
Bell, J. R., Raaijmakers, A. J. A., Curl, C. L., Reichelt, M. E., Harding, T. W., Bei, A., … Erickson, J. R., … Delbridge, L. M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159
Journal - Research Article
Jian, Z., Han, H., Zhang, T., Puglisi, J., Izu, L. T., Shaw, J. A., … Erickson, J. R., … Chen-Izu, Y. (2014). Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling, 7(317), ra27. doi: 10.1126/scisignal.2005046
Journal - Research Article
Zhang, D.-M., Chai, Y., Erickson, J. R., Brown, J. H., Bers, D. M., & Lin, Y.-F. (2014). Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. Journal of Physiology, 592(5), 971-990. doi: 10.1113/jphysiol.2013.264697
Journal - Research Article
Erickson, J. (2014, November). Activation mechanisms of CaMKII in the heart. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Bell, J. R., Erickson, J. R., & Delbridge, L. M. D. (2014). Ca2+/calmodulin dependent kinase II: A critical mediator in determining reperfusion outcomes in the heart? Clinical & Experimental Pharmacology & Physiology, 41(11), 940-946. doi: 10.1111/1440-1681.12301
Journal - Research Article
Erickson, J. R. (2014). Mechanisms of CaMKII activation in the heart. Frontiers in Pharmacology, 5, 59. doi: 10.3389/fphar.2014.00059
Journal - Research Article
Erickson, J. R. (2013, August). A novel mechanism for activation of calcium/calmodulin dependent kinase II during hyperglycemia. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Erickson, J. R., Pereira, L., Wang, L., Han, G., Ferguson, A., Dao, K., … Bers, D. M. (2013). Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature, 502, 372-376. doi: 10.1038/nature12537
Journal - Research Article
