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Lamberts Lab

Lab personnel

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Research interests

How the heart maintains its function under conditions of stress has been the major focus of my research career. My research aims to determine the changes in autonomic regulation of heart function (brain-heart axis) in diabetes, and how the fat surrounding the heart affects cardiac function. My lab generates biomedical data at the cellular and organ level, and obtains functional human myocardial and clinical data through HeartOtago. This translational knowledge creates the platform that is vital for the development of more specific therapeutics for the increasing cohort of individuals with obesity and diabetes to improve their health.

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Expertise

  • Diabetes, Atrial Fibrillation, Obesity, Pulmonary Hypertension, Ischemia, Hypertrophy and Heart Failure models
  • Ex vivo isolated cardiac muscles (papillary muscles, trabeculae, human and rat)
  • Ex vivo isolated Langendorff-perfused hearts for simultaneous LV and RV pressure and coronary flow measurements (rats and mice)
  • Human epicardial adipose tissue culture

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Current funding

  • Identification of epicardial fat factors that increase fibrillation of the heart; Heart Foundation (PI)
  • Effect of ethnicity on cardiac pathophysiology of cardiac surgery patients; BMS Dean’s Bequest (PI)
  • Why can’t the diabetic heart rest?; Heart Foundation (AI)
  • The circadian heart rhythm: external or internal clock?; Maurice and Phyllis Paykel Trust (AI)
  • Nitric oxide as a mediator of cardiac signalling; Marsden Fund (AI)

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Previous funding

  • Heart Foundation (2017-2018)
  • Otago Medical Research Foundation (2016)
  • OMS Collaborative Research Grant (2015)
  • HealthCare Otago Charitable Trust NZ (2013 and 2011)
  • University of Otago Research grant (2012 and 2014)
  • Heart Foundation NZ (2012)
  • OMRF Laurenson Award NZ (2012)

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Selected publications

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Bussey, C. T., & Lamberts, R. R. (2017). Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiological Reports, 5(14), e13352. doi: 10.14814/phy2.13352

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology, 102(8), 911-923. doi: 10.1113/ep086293

Aitken-Buck, H. M., & Lamberts, R. R. (2017). To the heart of activation heat. Journal of Physiology, 595(14), 4577-4578. doi: 10.1113/jp274582

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204

Jahn, N., Lamberts, R. R., Busch, C. J., Voelker, M. T., Koel-Simmelink, M. J. A., Teunissen, C. E., … Weimann, J. (2015). Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. Respiratory Research, 16, 119. doi: 10.1186/s12931-015-0274-7

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2014). Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo. Cardiovascular Diabetology, 13, 161. doi: 10.1186/s12933-014-0161-4

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Smeding, L., van der Laarse, W. J., van Veelen, T. A., Lamberts, R. R., Niessen, H. W. M., Kneyber, M. C. J., … Plötz, F. B. (2012). Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis. Journal of Surgical Research, 176(1), 178-184. doi: 10.1016/j.jss.2011.05.055

Smeding, L., Plötz, F. B., Lamberts, R. R., van der Laarse, W. J., Kneyber, M. C. J., & Groeneveld, A. B. J. (2012). Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Respiratory Research, 13, 23. doi: 10.1186/1465-9921-13-23

de Mooji, Y. M., Bartelings, M. M., Twisk, J. W. R., Lamberts, R. R., Gittenberger-de Groot, A. C., van Vugt, J. M. G., & Bekker, M. N. (2010). Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. American Journal of Obstetrics & Gynecology, 202(6), e566.1-e566.8. doi: 10.1016/j.ajog.2010.01.054

Bouwman, R. A., Vreden, M. J. A., Hamdani, N., Wassenaar, L. E. J., Smeding, L., Loer, S., … Lamberts, R. R. (2010). Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts. European Journal of Pharmacology, 647(1-3), 132-138. doi: 10.1016/j.ejphar.2010.08.014

Journal - Research Article

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise. Advance online publication. doi: 10.1249/mss.0000000000001897

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology. Advance online publication. doi: 10.1113/EP087437

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology, 102(8), 911-923. doi: 10.1113/ep086293

Bussey, C. T., & Lamberts, R. R. (2017). Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiological Reports, 5(14), e13352. doi: 10.14814/phy2.13352

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Jahn, N., Lamberts, R. R., Busch, C. J., Voelker, M. T., Koel-Simmelink, M. J. A., Teunissen, C. E., … Weimann, J. (2015). Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. Respiratory Research, 16, 119. doi: 10.1186/s12931-015-0274-7

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R., … Katare, R. (2015). Data supporting the activation of autophagy genes in the diabetic heart. Data in Brief, 5, 269-275. doi: 10.1016/j.dib.2015.09.003

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2014). Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo. Cardiovascular Diabetology, 13, 161. doi: 10.1186/s12933-014-0161-4

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Smeding, L., Plötz, F. B., Lamberts, R. R., van der Laarse, W. J., Kneyber, M. C. J., & Groeneveld, A. B. J. (2012). Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Respiratory Research, 13, 23. doi: 10.1186/1465-9921-13-23

Smeding, L., van der Laarse, W. J., van Veelen, T. A., Lamberts, R. R., Niessen, H. W. M., Kneyber, M. C. J., … Plötz, F. B. (2012). Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis. Journal of Surgical Research, 176(1), 178-184. doi: 10.1016/j.jss.2011.05.055

de Mooji, Y. M., Bartelings, M. M., Twisk, J. W. R., Lamberts, R. R., Gittenberger-de Groot, A. C., van Vugt, J. M. G., & Bekker, M. N. (2010). Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. American Journal of Obstetrics & Gynecology, 202(6), e566.1-e566.8. doi: 10.1016/j.ajog.2010.01.054

Bouwman, R. A., Vreden, M. J. A., Hamdani, N., Wassenaar, L. E. J., Smeding, L., Loer, S., … Lamberts, R. R. (2010). Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts. European Journal of Pharmacology, 647(1-3), 132-138. doi: 10.1016/j.ejphar.2010.08.014

Handoko, M. L., Lamberts, R. R., Redout, E. M., de Man, F. S., Boer, C., Simonides, W. S., … Vonk-Noordegraaf, A. (2009). Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: A study in the isolated heart. American Journal of Physiology: Heart & Circulatory Physiology, 297(5), H1752-H1759. doi: 10.1152/ajpheart.00555.2009

Hamdani, N., de Waard, M., Messer, A. E., Boontje, N. M., Kooij, V., van Dijk, S., … Lamberts, R., … van der Velden, J. (2009). Myofilament dysfunction in cardiac disease from mice to men. Journal of Muscle Research & Cell Motility, 29(6-8), 189-201. doi: 10.1007/s10974-008-9160-y

Lamberts, R. R., Onderwater, G., Hamdani, N., Vreden, M. J. A., Steenhuisen, J., Eringa, E. C., … Bouwman, R. A. (2009). Reactive oxygen species—induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Circulation, 120(Suppl. 1), S10-S15. doi: 10.1161/CIRCULATIONAHA.108.828426

Lamberts, R. R., Caldenhoven, E., Lansink, M., Witte, G., Vaessen, R. J., St Cyr, J. A., & Stienen, G. J. M. (2007). Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. American Journal of Physiology: Heart & Circulatory Physiology, 293(4), H1869-H1876. doi: 10.1152/ajpheart.00294.2007

Lamberts, R. R., Hamdani, N., Soekhoe, T. W., Boontje, N. M., Zaremba, R., Walker, L. A., … Stienen, G. J. M. (2007). Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Journal of Physiology, 582(2), 695-709. doi: 10.1113/jphysiol.2007.134486

Bouwman, R. A., Musters, R. J. P., van Beek-Harmsen, B. J., de Lange, J. J., Lamberts, R. R., Loer, S., & Boer, C. (2007). Sevoflurane-induced cardioprotection depends on PKC-α activation via production of reactive oxygen species. British Journal of Anaesthesia, 99(5), 639-645. doi: 10.1093/bja/aem202

Lamberts, R. R., Vaessen, R. J., Westerhof, N., & Stienen, G. J. M. (2007). Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Basic Research in Cardiology, 102(1), 19-27. doi: 10.1007/s00395-006-0620-5

van der Velden, J., Narolska, N. A., Lamberts, R. R., Boontje, N. M., Borbély, A., Zaremba, R., … Stienen, G. J. M. (2006). Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. Cardiovascular Research, 69, 876-887. doi: 10.1016/j.cardiores.2005.11.021

Westerhof, N., Boer, C., Lamberts, R. R., & Sipkema, P. (2006). Cross-talk between cardiac muscle and coronary vasculature. Physiological Reviews, 86(4), 1268-1308. doi: 10.1152/physrev.00029.2005

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Journal - Research Other

Aitken-Buck, H. M., & Lamberts, R. R. (2017). To the heart of activation heat. Journal of Physiology, 595(14), 4577-4578. doi: 10.1113/jp274582

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

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Conference Contribution - Published proceedings: Abstract

Lamberts, R., Bussey, C., Wilson, G., & Baldi, C. (2018). Resting heart rate in type 2 diabetes in humans and rats. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S126). doi: 10.1016/j.hlc.2018.06.186

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018

Bussey, C., Iremonger, R., Lamberts, R., & Erickson, J. (2018). Myocardial impairments preceding overt in vivo cardiac dysfunction are prevented by beta blockade in type 2 diabetic Zucker diabetic fatty rats. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S114). doi: 10.1016/j.hlc.2018.06.158

Greenman, A., Diffee, G., Wallace, R., Lamberts, R., Erickson, J., & Baldi, C. (2018). Reduced myofilament calcium-sensitivity occurs without phosphorylation of cTnI serine 23/24 in human diabetic cardiomyocytes. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S125). doi: 10.1016/j.hlc.2018.06.184

Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β1-but not β3-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283

Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093

Baldi, J. C., Wilkins, G. T., Lamberts, R. R., & Diffee, G. M. (2018). Reduced myofilament calcium-sensitivity in diabetic human left ventricular cardiomyocytes. Cardiovascular Research, 114(Suppl. 1), (pp. S24). doi: 10.1093/cvr/cvy060.056

Bussey, C. T., Wallace, R. S., Lamberts, R. R., & Erickson, J. R. (2017). Beta-blockade restores myocardial function in type 2 diabetic rats via CaMKII-independent mechanisms. Journal of Molecular & Cellular Cardiology, 109(Suppl.), (pp. 34). doi: 10.1016/j.yjmcc.2017.06.002

Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2017). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. New Zealand Medical Journal, 130(1467), (pp. 104). Retrieved from http://www.nzma.org.nz/journal

Koutsifeli, P., Benson, V., Liu, J., Lamberts, R., Delbridge, L., & Mellor, K. (2017). Cardiac metabolic and autophagy gene networks are differentially regulated in models of type 1 diabetes, insulin resistance and type 2 diabetes. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S103). doi: 10.1016/j.hlc.2017.06.138

Lamberts, R. R., Cook, R. F., Bussey, C. T., & Cragg, P. A. (2016). Beta1-, and beta2-adrenoceptor responsiveness in the heart during type 2 diabetes. Diabetologia, 59(Suppl. 1), (pp. S517). doi: 10.1007/s00125-016-4046-9

Erickson, J., Lamberts, R., & Daniels, L. (2016). CaMKII inhibition restores contractility in trabeculae from diabetic rats. Heart, Lung & Circulation, 25(Suppl. 2), (pp. S84-S85). doi: 10.1016/j.hlc.2016.06.197

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2016). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. Proceedings of The Physiological Society, PCB038 . Retrieved from http://www.physoc.org

Cook, R. F., Hughes, G., Bussey, C. T., Cragg, P. A., & Lamberts, R. R. (2015). Mechanically indepdendent ventricular beta2-adrenoceptor stimulation compensates for reduced contractile function in type-2 diabetes. European Heart Journal, 36(Suppl. 1), (pp. 184). doi: 10.1093/eurheartj/ehv399

Lamberts, R. R., Hughes, G., Bussey, C. T., Saxena, P., Galvin, I. F., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., on behalf of HeartOtago. (2015). Left ventricular calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 312-313). doi: 10.1093/eurheartj/ehv399

Bussey, C. T., & Lamberts, R. R. (2015). Individual contributions of isoflurane anaesthesia and surgical incision to haemodynamic regulation in Zucker Diabetic Fatty rats in vivo. Proceedings of the Australian Physiological Society (AuPS) Conference. Retrieved from http://aups.org.au/Meetings/201511/

Cook, R., Bussey, C., Cragg, P., & Lamberts, R. (2014). Is myocardial β1- and β2-adrenoceptor responsiveness altered in conscious Zucker Diabetic Fatty rats? Heart, Lung & Circulation, 23(Suppl. 1), (pp. e21). doi: 10.1016/j.hlc.2014.04.182

Bussey, C., de Leeuw, A., & Lamberts, R. (2014). Increased hemodynamic adrenergic load in conscious and anaesthetised type 2 diabetic rats. New Zealand Medical Journal, 127(1398). Retrieved from http://www.nzma.org.nz/journal

Lamberts, R., de Leeuw, A., & Bussey, C. (2014). Exacerbated α-adrenoceptor-mediated vasoconstriction in obese rats during anesthesia. FASEB Journal, 28(1, Suppl.), 681.8. [Abstract]

Cook, R., Bussey, C., Cragg, P., & Lamberts, R. (2014). Hemodynamic effects of β1- and β2-adrenoreceptor stimulation in conscious Zucker diabetic fatty rats. FASEB Journal, 28(1, Suppl.), 1155.7. [Abstract]

Wilson, L., Coffey, S., Hoye, N., Murray, A., Lamberts, R., Williams, M., Wilkins, G., & Baldi, J. C. (2014). Impaired cardiac parasympathetic control in healthy young people with type 1 diabetes. FASEB Journal, 28(1, Suppl.), LB658. [Abstract]

Cook, R., Bussey, C., Cragg, P., & Lamberts, R. (2014). Modulation of heart rate by specific β1- and β2-adrenoceptor stimulation in conscious Zucker type II Diabetic Fatty rats. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Bussey, C., de Leeuw, A., & Lamberts, R. (2014). Increased α-adrenoceptor sensitivity in Zucker diabetic fatty rats during anesthesia. FASEB Journal, 28(1, Suppl.), 1155.6. [Abstract]

Lamberts, R., Lingam, S., Wang, S., Saxena, P., Galvin, I., Bunton, R., Williams, M., Coffey, S., Baldi, J., & Jones, P. (2013). Impaired functional relaxation despite upregulated calcium handling proteins in human diabetic myocardium. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S57). doi: 10.1016/j.hlc.2013.05.137

Lingam, S. J., Saxena, P., Coffey, S., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Hastened relaxation in a non-failing diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 67). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Thaung, A., Baldi, C., Schwenke, D., & Lamberts, R. (2012). Sympathetic modulation of cardiac function in diabetes: Paired in vivo and ex vivo study. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Wang, H.-Y., Baldi, J. C., & Lamberts, R. R. (2012). Is the reduced B-adrenergic responsiveness in the diabetic rat heart due to chronotropic and/or inotropic changes? Proceedings of the Medical Sciences Congress (MedSci). (pp. 69). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Lingam, S., Saxena, P., Coffey, S., Williams, M., Baldi, J., Lamberts, R., & Jones, P. (2012). Improved atrial relaxation in human type 2 diabetes mellitus. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2012). Interaction between altered adrenoreceptor function and anaesthesia in obesity in vivo. Proceedings of the Medical Sciences Congress (MedSci). (pp. 66). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Wang, H.-Y., Baldi, J., Saxena, P., Coffey, S., Williams, M., & Lamberts, R. (2012). Reduced cardiac function and β-adrenergic receptor responsiveness in the isolated human diabetic myocardium. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Thaung, H. P. A., Yao, Y., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2012). Renal denervation does not restore the attenuated cardiac response to β-adrenergic stimulation in the hypertensive diabetic rat. Heart, Lung & Circulation, 21(12), (pp. 859-860). doi: 10.1016/j.hlc.2012.08.022

Wang, H.-Y., Baldi, J., & Lamberts, R. (2012). Reduced cardiac response to β–adrenergic stimulation in the diabetic rat heart. New Zealand Medical Journal, 125(1355). Retrieved from http://www.nzma.org.nz/journal

Lamberts, R., Wang, H.-Y., & Baldi, J. (2012). Chronotropic and inotropic modulation by β-adrenergic stimulation in the diabetic rat heart. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S56-S57). doi: 10.1016/j.hlc.2012.05.144

Thaung, A., & Lamberts, R. (2011). The cardiac response to β-adrenergic stimulation is reduced in the obese rat heart: The role of adenonsine monophosphate-activated protein kinase (AMPK). New Zealand Medical Journal, 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Thaung, A., Sammut, I., Yao, Y., & Lamberts, R. (2011). Effect of chronic renal denervation on cardiac response to β-adrenergic stimulation in diabetic hypertensive rat model. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf

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Conference Contribution - Poster Presentation (not in published proceedings)

Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Satthenapalli, V. R., Hore, T. A., Lamberts, R. R., & Katare, R. (2017, September). Ventricle-specific cardiomyocyte differentiation of mouse embryonic stem cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Aitken-Buck, H. M., Appleby, S., Pemberton, C. J., & Lamberts, R. R. (2017, September). Myoregulin has no effect on contraction or relaxation of isolated rat hearts. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Satthenapalli, R., Hore, T. A., Lamberts, R. R., & Katare, R. (2016, August). Ventricular specific cardiomyocyte differentiation of mouse embryonic stem cells through modulation of molecular pathways. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Hamer, N. S. J., & Lamberts, R. R. (2013, August). Right atrial and left ventricular isolated trabeculae show functional similarities. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2013, August). Alpha-, but not beta-, adrenoreceptor cardiovascular responses are exacerbated by anaesthesia in obese rats. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Wang, H.-Y., Baldi, J. C., & Lamberts, R. R. (2012, September). Reduced β-adrenergic responsiveness in the diabetic rat heart. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Thaung, H. P. A., Baldi, J. C., Schwenke, D. O., & Lamberts, R. R. (2012, September). Direct recording of sympathetic drive to the heart in vivo and cardiac responsiveness to β-adrenergic stimulation ex vivo in diabetic rats. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012, September). Improved atrial relaxation in human type 2 diabetes mellitus. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Thaung, H. P. A., & Lamberts, R. R. (2011, September). Cardiac response to β-adrenergic stimulation is reduced in the obese rat heart: The role of adenosine monophosphate-activated protein kinase (AMPK). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bouwman, R. A., van den Brom, C. E., & Lamberts, R. R. (2010, November-December). Diet composition induces metabolic changes that alter myocardial function, resistance to ischemia and cardioprotection in the rat heart. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2017, September). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. Invited presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Calverley, J. R., Erickson, J. R., & Lamberts, R. R. (2017, September). Determining the physiological importance of CaMKII in alpha-adrenergic (α-AR) regulation of heart function in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F., Pereira, L., Bers, D. M., & Erickson, J. R. (2017, September). The role of calcium calmodulin dependent protein kinase II in type 2 diabetic cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F. J., & Erickson, J. R. (2016, August). CaMKII inhibition restores contractile performance in cardiac muscle from a rat model of type 2 diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Daniels, L. J., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2016, August-September). The effects of CaMKII inhibition on post-rest behavior and spontaneous contractions in isolated Zucker diabetic fatty rat cardiac muscle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Lamberts, R. (2016, August-September). Changes in β-AR signalling in the human diabetic heart. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Lamberts, R. (2014, November). Impaired relaxation in human diabetic myocardium...or not? Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

Lingam, S. J., Wang, S. H. Y., Saxena, P., Galvin, I. F., Bunton, R. W., Williams, M. J. A., Coffey, S., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2013, August). Relaxation in human diabetic myocardium. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2013, August). Exacerbated alpha adrenoceptor-mediated vasoconstriction in obese rats during anaesthesia. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hamer, N. S. J., & Lamberts, R. R. (2013, August). Functional myocardial similarities between right atrial and left ventricular isolated trabeculae. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Thaung, H. P. A., Yao, Y., Sammut, I. A., & Lamberts, R. R. (2011, August). The effect of chronic renal denervation on cardiac response to β-adrenergic stimulation in hypertensive diabetic rat. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

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