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Associate Professor Peter Larsen

Peter Larsen Thumbnail

BSc(Hons), PhD (Otago)

Background

After completing a BSc with Honours at Victoria University of Wellington, I undertook a PhD at the University of Otago. This focused on understanding the interactions between cardiovascular and respiratory control. I then did a postdoctoral fellowship at Michigan State University examined neural control of the cardiovascular system, before returning to the University of Otago, Wellington.

My research interests are now in clinical cardiovascular medicine, including the use of biomarkers in risk stratification, acute myocardial infarction, use of implanted cardiac devices and personalized approaches to clinical care. Application of cardiovascular physiology to clinical questions remains an area of interest for me. In addition, I am involved in supporting registrar research activities in a range of clinical settings.

Contact details

Department of Surgery & Anaesthesia
University of Otago, Wellington
PO Box 7343
Wellington South

Email peter.larsen@otago.ac.nz

Associate Professor Larsen's Health Sciences database profile page

Current roles

  • Head of Department, Surgery and Anaesthesia
  • Head of Department, Radiation Therapy
  • Co-Director, Wellington Cardiovascular Research Group
  • Course Director, Medical Technology Programme

Research expertise

  • Acute Coronary Syndromes
  • Biomarkers in Clinical Cardiology
  • Sudden Cardiac Death
  • Defibrillation
  • Implantable Cardioverter Defibrillators
  • Heart Rate Variability
  • Respiratory Variability
  • Quality Improvement in Clinical Care
  • Clinical Cancer Research

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Publications

Rogan, A., Patel, V., Birdling, J., Lockett, J., Simmonds, H., McQuade, D., & Larsen, P. (2021). Acute traumatic brain injury and the use of head computed tomography scans in the emergency department. Trauma. Advance online publication. doi: 10.1177/14604086211023646

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis. Advance online publication. doi: 10.1055/s-0041-1728763

Marsters, B., Shi, B., Wheeler, B. J., Boucher, S., Macaulay, G., Galland, B., Elder, D., Larsen, P., & Wiltshire, E. (2021). Advanced ECG analysis of cardiac function in children and adolescents with type 1 diabetes: A pilot study [Short communication]. Acta Diabetologica. Advance online publication. doi: 10.1007/s00592-021-01704-y

Cognasse, F., Hally, K., Fauteux-Daniel, S., Eyraud, M.-A., Arthaud, C.-A., Fagan, J., … Larsen, P. (2021). Effects and side effects of platelet transfusion. Hamostaseologie. Advance online publication. doi: 10.1055/a-1347-6551

Russell, N., Black, M., Larsen, P., & Benton, M. (2021). Deep learning in a clinical context: The big picture from "big data". Proceedings of the eResearch NZ Conference. (pp. 103). Retrieved from https://www.eresearchnz2021.org.nz

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis. Advance online publication. doi: 10.1055/s-0041-1728763

Journal - Research Article

Rogan, A., Patel, V., Birdling, J., Lockett, J., Simmonds, H., McQuade, D., & Larsen, P. (2021). Acute traumatic brain injury and the use of head computed tomography scans in the emergency department. Trauma. Advance online publication. doi: 10.1177/14604086211023646

Journal - Research Article

Rogan, A., Patel, V., Birdling, J., Lockett, J., Simmonds, H., McQuade, D., Quigley, P., & Larsen, P. (2021). Alcohol and acute traumatic brain injury in the emergency department. Emergency Medicine Australasia. Advance online publication. doi: 10.1111/1742-6723.13726

Journal - Research Article

Ady Wirawan, I. M., Griffiths, R. F., & Larsen, P. D. (2020). Cardiovascular risk factor modification in asymptomatic adults and implications for pilots. Journal of UOEH, 42(2), 187-201. doi: 10.7888/juoeh.42.187

Journal - Research Article

Foo, F. S., Lee, M., Looi, K.-L., Larsen, P., Clare, G. C., Heaven, D., … on behalf of the ANZACS-QI investigators. (2020). Implantable cardioverter defibrillator and cardiac resynchronization therapy use in New Zealand (ANZACS-QI 33). Journal of Arrhythmia, 36, 153-163. doi: 10.1002/joa3.12244

Journal - Research Article

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2020). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica, 75(6), 497-502. doi: 10.1080/00015385.2019.1611189

Journal - Research Article

Kane, P., Larsen, P., & Wiltshire, E. (2020). Early identification of cardiac autonomic neuropathy using complexity analysis in children with type 1 diabetes. Journal of Paediatrics & Child Health, 56, 786-790. doi: 10.1111/jpc.14745

Journal - Research Article

Kristono, G. A., Holley, A. S., Hally, K. E., Brunton-O'Sullivan, M. M., Shi, B., Harding, S. A., & Larsen, P. D. (2020). An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction. Cytokine: X, 2, 100037. doi: 10.1016/j.cytox.2020.100037

Journal - Research Article

Kristono, G. A., Holley, A. S., Harding, S. A., & Larsen, P. D. (2020). White blood cell subtypes as predictors of adverse cardiac events. Coronary Artery Disease, 31(5), 446-450. doi: 10.1097/mca.0000000000000860

Journal - Research Article

Kristono, G. A., Holley, A. S., Lakshman, P., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2020). Association between inflammatory cytokines and long-term adverse outcomes in acute coronary syndromes: A systematic review. Heliyon, 6(4), e03704. doi: 10.1016/j.heliyon.2020.e03704

Journal - Research Article

de Burlet, K. J., Desmond, B., Matsis, R., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2020). Reducing length of stay for patients presenting to general surgery with acute non-surgical abdominal pain. ANZ Journal of Surgery, 90, 2259-2263. doi: 10.1111/ans.16276

Journal - Research Article

Bond, E. C., Phillips, P., Larsen, P. D., Hunt, L., & Willoughby, R. (2019). Long-term hip function in slipped capital femoral epiphysis treated with in situ pinning. Journal of Orthopaedic Surgery, 27(1), 1-6. doi: 10.1177/2309499018822234

Journal - Research Article

Foo, F. S., Lee, M., Heaven, D., Lever, N., Sinclair, S., Stiles, M. K., Harding, S., … Larsen, P., … on behalf of the ANZACS-QI investigators. (2019). Completeness of ANZACS-QI Cardiac Implanted DEVICE Registry and agreement with national datasets: ANZACS-QI 30. New Zealand Medical Journal, 132(1500), 40-49. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hally, K. E., Bird, G. K., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation. PLoS ONE, 14(10), e0223444. doi: 10.1371/journal.pone.0223444

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: Results of a randomized, cross-over trial. Platelets, 30(5), 599-607. doi: 10.1080/09537104.2018.1479520

Journal - Research Article

Hancock, D. S., Sharplin, P. K., Larsen, P. D., & Phillips, F. T. S. (2019). Early radiological and functional outcomes for a cementless press-fit design modular femoral stem revision system. HIP International, 29(1), 35-40. doi: 10.1177/1120700018760277

Journal - Research Article

Tinawi, G., Gunawardene, A., Shekouh, A., Larsen, P. D., & Dennett, E. R. (2019). Neoadjuvant therapy in rectal cancer: How are we choosing? ANZ Journal of Surgery, 89, 68-73. doi: 10.1111/ans.14935

Journal - Research Article

Wilkins, B., Hullikunte, S., Simmonds, M., Sasse, A., Larsen, P., & Harding, S. A. (2019). Improving the prescribing gap for guideline recommended medications post myocardial infarction. Heart, Lung & Circulation, 28(2), 257-262. doi: 10.1016/j.hlc.2017.10.025

Journal - Research Article

de Burlet, K. J., Lam, A. B. M., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2019). Can surgical registrars accurately identify the urgent from the non-urgent patient presenting with acute abdominal pain? European Surgical Research, 60(1-2), 24-30. doi: 10.1159/000496021

Journal - Research Article

Ady Wirawan, I. M., Griffiths, R. F., & Larsen, P. D. (2018). Cardiovascular tests for risk assessment in asymptomatic adults and implications for pilots. Aerospace Medicine & Human Performance, 89(7), 648-656. doi: 10.3357/amhp.5065.2018

Journal - Research Article

Gunawardene, A., Desmond, B., Shekouh, A., Larsen, P., & Dennett, E. (2018). Disease recurrence following surgery for colorectal cancer: Five-year follow-up. New Zealand Medical Journal, 131(1469), 51-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Gunawardene, A., Larsen, P., Shekouh, A., & Dennett, E. (2018). Pre-operative carcinoembryonic antigen predicts survival following colorectal cancer surgery with curative intent. ANZ Journal of Surgery, 88, 1311-1315. doi: 10.1111/ans.14723

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). Platelets regulate leucocyte responses to Toll-like receptor stimulation. Clinical & Translational Immunology, 7, e1036. doi: 10.1002/cti2.1036

Journal - Research Article

Hancock, D. S., Rupasinghe, S. L., Elkinson, I., Bloomfield, M. G., & Larsen, P. D. (2018). Benzoyl peroxide + chlorhexidine versus chlorhexidine alone skin preparation to reduce Propionibacterium acnes: A randomized controlled trial. ANZ Journal of Surgery, 88, 1182-1186. doi: 10.1111/ans.14848

Journal - Research Article

O'Connor, M., Hooks, D., Webber, M., Shi, B., Morrison, S., Harding, S., & Larsen, P. (2018). Long-term single-center comparison of ICD lead survival: Evidence for premature Linox lead failure. Journal of Cardiovascular Electrophysiology, 29(7), 1024-1031. doi: 10.1111/jce.13502

Journal - Research Article

de Burlet, K. J., Desmond, B., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2018). Patients requiring an acute operation: Where are the delays in the process? ANZ Journal of Surgery, 88, 865-869. doi: 10.1111/ans.14718

Journal - Research Article

de Burlet, K. J., MacKay, M., Larsen, P., & Dennett, E. R. (2018). Appropriateness of CT scans for patients with non-traumatic acute abdominal pain. British Journal of Radiology, 91(1088), 20180158. doi: 10.1259/bjr.20180158

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2017). Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thrombosis Research, 158, 8-15. doi: 10.1016/j.thromres.2017.07.031

Journal - Research Article

Harding, S. A., Holley, A., Wilkins, B., Fairley, S., Simmonds, M., & Larsen, P. D. (2017). Contemporary antiplatelet therapy in acute coronary syndromes: Are there differences in outcomes and discontinuation between clopidogrel and ticagrelor? Internal Medicine Journal, 47(11), 1298-1305. doi: 10.1111/imj.13595

Journal - Research Article

Holley, A., Pitman, J., Miller, J., Harding, S., & Larsen, P. (2017). Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Journal of Investigative Medicine, 65(5), 919-925. doi: 10.1136/jim-2016-000361

Journal - Research Article

Larsen, P. D., Holley, A. S., Sasse, A., Al-Sinan, A., Fairley, S., & Harding, S. A. (2017). Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thrombosis Research, 152, 14-19. doi: 10.1016/j.thromres.2017.02.006

Journal - Research Article

Larsen, P. D., Kerr, A. J., Hood, M., Harding, S. A., Hooks, D., Heaven, D., … on behalf of the ANZACS-QI Investigators. (2017). Pacemaker use in New Zealand: Data from the New Zealand Implanted Cardiac Device Registry (ANZACS-QI 15). Heart, Lung & Circulation, 26(3), 235-239. doi: 10.1016/j.hlc.2016.06.1206

Journal - Research Article

Matsis, K., Holley, A., Al-Sinan, A., Matsis, P., Larsen, P. D., & Harding, S. A. (2017). Differing clinical characteristics between young and older patients presenting with myocardial infarction. Heart, Lung & Circulation, 26(6), 566-571. doi: 10.1016/j.hlc.2016.09.007

Journal - Research Article

Roberts, T., Campbell, A., Larsen, P., & Elder, D. (2017). Preterm infants at discharge: Nap polysomnography versus 24-hour oximetry. Acta Paediatrica, 106(111), 1754-1759. doi: 10.1111/apa.13900

Journal - Research Article

Shi, B., Harding, S., & Larsen, P. (2017). Analysis of ECG measures of cardiac repolarization in relation to arrhythmic events in an implantable cardioverter defibrillator population. Annals of Noninvasive Electrocardiology, 22(2), e12390. doi: 10.1111/anec.12390

Journal - Research Article

de Burlet, K., Lam, A., Larsen, P., & Dennett, E. (2017). Acute abdominal pain: Changes in the way we assess it over a decade. New Zealand Medical Journal, 130(1463), 39-44. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Fake, A. L., Harding, S. A., Matsis, P. P., & Larsen, P. D. (2016). Pharmacological therapy following acute coronary syndromes in patients with atrial fibrillation: How do we balance ischaemic risk with bleeding risk? New Zealand Medical Journal, 129(1435), 39-49. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2016). Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy. Thrombosis Research, 148, 89-95. doi: 10.1016/j.thromres.2016.10.026

Journal - Research Article

Holley, A. S., Miller, J. H., Larsen, P. D., & Harding, S. A. (2016). Relationship between glutathione peroxidase, platelet reactivity, and reactive oxygen species in an acute coronary syndrome population. Annals of Clinical & Laboratory Science, 46(6), 639-644.

Journal - Research Article

Holley, A., Harding, S., Sasse, A., Miller, J., & Larsen, P. (2016). Reduced glutathione peroxidase activity predicts increased cardiovascular risk following an acute coronary syndrome. International Cardiovascular Forum Journal, 6, 61-65. doi: 10.17987/icfj.v6i0.241

Journal - Research Article

Nichol, G., Brown, S. P., Perkins, G. D., Kim, F., Sterz, F., Elrod, J. A. B., … Larsen, P., … Sayre, M. (2016). What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey. Resuscitation, 107, 115-120. doi: 10.1016/j.resuscitation.2016.08.004

Journal - Research Article

Wolbinski, M., Swain, A. H., Harding, S. A., & Larsen, P. D. (2016). Out-of-hospital cardiac arrest patient characteristics: Comparing ventricular arrthymia and pulseless electrical activity. Heart, Lung & Circulation, 25(7), 639-644. doi: 10.1016/j.hlc.2016.02.001

Journal - Research Article

Furniss, G., Shi, B., Jimenez, A., Harding, S. A., & Larsen, P. D. (2015). Cardiac troponin levels following implantable cardioverter defibrillation implantation and testing. Europace, 17(2), 262-266. doi: 10.1093/europace/euu306

Journal - Research Article

Johnston, J. W., Larsen, P., El-Haddawi, F. H., Fancourt, M. W., Farrant, G. J., Gilkison, W. T. C., … Mosquera, D. A. (2015). Time delays in presentation and treatment of acute scrotal pain in a provincial hospital. ANZ Journal of Surgery, 85(5), 330-333. doi: 10.1111/ans.12601

Journal - Research Article

Larsen, P. D., Johnston, L. R., Holley, A., La Flamme, A., Smyth, L., Chua, E. W., Kennedy, M. A., & Harding, S. A. (2015). Prevalence and significance of CYP2C19*2 and CYP2C19*17 alleles in a New Zealand acute coronary syndrome population. Internal Medicine Journal, 45(5), 537-545. doi: 10.1111/imj.12698

Journal - Research Article

Webb, I. G., Yam, S. T., Cooke, R., Aitken, A., Larsen, P. D., & Harding, S. A. (2015). Elevated baseline cardiac troponin levels in the elderly: Another variable to consider? Heart, Lung & Circulation, 24(2), 142-148. doi: 10.1016/j.hlc.2014.07.071

Journal - Research Article

Ady Wirawan, I. M., Wu, R., Abernethy, M., Aldington, S., & Larsen, P. D. (2014). Calcium scores in the risk assessment of an asymptomatic population: Implications for airline pilots. Aviation, Space, & Environmental Medicine, 85(8), 812-817. doi: 10.3357/ASEM.3904.2014

Journal - Research Article

Shi, B., Ferrier, K. A., Sasse, A., Harding, S. A., & Larsen, P. D. (2014). Correlation between vectorcardiographic measures and cardiac magnetic resonance imaging of the left ventricle in an implantable cardioverter defibrillator population. Journal of Electrocardiology, 47(1), 52-58. doi: 10.1016/j.jelectrocard.2013.06.018

Journal - Research Article

Ady Wirawan, I. M., Aldington, S., Griffiths, R. F., Ellis, C. J., & Larsen, P. D. (2013). Cardiovascular investigations of airline pilots with excessive cardiovascular risk. Aviation, Space, & Environmental Medicine, 84(6), 608-612. doi: 10.3357/ASEM.3465.2013

Journal - Research Article

Fake, A. L., Swain, A. H., & Larsen, P. D. (2013). Survival from out-of-hospital cardiac arrest in Wellington in relation to socioeconomic status and arrest location. New Zealand Medical Journal, 126(1376). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

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