Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Associate Professor Peter Larsen, Department of Surgery and Anaesthesia

Peter Larsen Thumbnail

BSc(Hons), PhD (Otago)

Background

After completing a BSc with Honours at Victoria University of Wellington, I undertook a PhD at the University of Otago. This focused on understanding the interactions between cardiovascular and respiratory control. I then did a postdoctoral fellowship at Michigan State University examined neural control of the cardiovascular system, before returning to the University of Otago, Wellington.

My research interests are now in clinical cardiovascular medicine, including the use of biomarkers in risk stratification, acute myocardial infarction, use of implanted cardiac devices and personalized approaches to clinical care. Application of cardiovascular physiology to clinical questions remains an area of interest for me. In addition, I am involved in supporting registrar research activities in a range of clinical settings.

Contact details

Department of Surgery & Anaesthesia
University of Otago, Wellington
PO Box 7343
Wellington South

Email peter.larsen@otago.ac.nz

Current roles

Head of Department, Surgery and Anaesthesia
Head of Department, Radiation Therapy
Co-Director, Wellington Cardiovascular Research Group
Course Director, Medical Technology Programme

Research expertise

Acute Coronary Syndromes
Biomarkers in Clinical Cardiology
Sudden Cardiac Death
Defibrillation
Implantable Cardioverter Defibrillators
Heart Rate Variability
Respiratory Variability
Quality Improvement in Clinical Care
Clinical Cancer Research

^ Top of page

Publications

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2019). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica. Advance online publication. doi: 10.1080/00015385.2019.1611189

de Burlet, K. J., Lam, A. B. M., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2019). Can surgical registrars accurately identify the urgent from the non-urgent patient presenting with acute abdominal pain? European Surgical Research, 60(1-2), 24-30. doi: 10.1159/000496021

Bond, E. C., Phillips, P., Larsen, P. D., Hunt, L., & Willoughby, R. (2019). Long-term hip function in slipped capital femoral epiphysis treated with in situ pinning. Journal of Orthopaedic Surgery, 27(1), 1-6. doi: 10.1177/2309499018822234

Wilkins, B., Hullikunte, S., Simmonds, M., Sasse, A., Larsen, P., & Harding, S. A. (2019). Improving the prescribing gap for guideline recommended medications post myocardial infarction. Heart, Lung & Circulation, 28(2), 257-262. doi: 10.1016/j.hlc.2017.10.025

Hancock, D. S., Rupasinghe, S. L., Elkinson, I., Bloomfield, M. G., & Larsen, P. D. (2018). Benzoyl peroxide + chlorhexidine versus chlorhexidine alone skin preparation to reduce Propionibacterium acnes: A randomized controlled trial. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.14848

Journal - Research Article

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2019). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica. Advance online publication. doi: 10.1080/00015385.2019.1611189

Wilkins, B., Hullikunte, S., Simmonds, M., Sasse, A., Larsen, P., & Harding, S. A. (2019). Improving the prescribing gap for guideline recommended medications post myocardial infarction. Heart, Lung & Circulation, 28(2), 257-262. doi: 10.1016/j.hlc.2017.10.025

Bond, E. C., Phillips, P., Larsen, P. D., Hunt, L., & Willoughby, R. (2019). Long-term hip function in slipped capital femoral epiphysis treated with in situ pinning. Journal of Orthopaedic Surgery, 27(1), 1-6. doi: 10.1177/2309499018822234

de Burlet, K. J., Lam, A. B. M., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2019). Can surgical registrars accurately identify the urgent from the non-urgent patient presenting with acute abdominal pain? European Surgical Research, 60(1-2), 24-30. doi: 10.1159/000496021

Hancock, D. S., Rupasinghe, S. L., Elkinson, I., Bloomfield, M. G., & Larsen, P. D. (2018). Benzoyl peroxide + chlorhexidine versus chlorhexidine alone skin preparation to reduce Propionibacterium acnes: A randomized controlled trial. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.14848

de Burlet, K. J., MacKay, M., Larsen, P., & Dennett, E. R. (2018). Appropriateness of CT scans for patients with non-traumatic acute abdominal pain. British Journal of Radiology. Advance online publication. doi: 10.1259/bjr.20180158

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). Platelets regulate leucocyte responses to Toll-like receptor stimulation. Clinical & Translational Immunology, 7, e1036. doi: 10.1002/cti2.1036

Gunawardene, A., Larsen, P., Shekouh, A., & Dennett, E. (2018). Pre-operative carcinoembryonic antigen predicts survival following colorectal cancer surgery with curative intent. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.14723

de Burlet, K. J., Desmond, B., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2018). Patients requiring an acute operation: Where are the delays in the process? ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.14718

Hancock, D. S., Sharplin, P. K., Larsen, P. D., & Phillips, F. T. S. (2018). Early radiological and functional outcomes for a cementless press-fit design modular femoral stem revision system. HIP International. Advance online publication. doi: 10.1177/1120700018760277

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: Results of a randomized, cross-over trial. Platelets. Advance online publication. doi: 10.1080/09537104.2018.1479520

Ady Wirawan, I. M., Griffiths, R. F., & Larsen, P. D. (2018). Cardiovascular tests for risk assessment in asymptomatic adults and implications for pilots. Aerospace Medicine & Human Performance, 89(7), 648-656. doi: 10.3357/amhp.5065.2018

Tinawi, G., Gunawardene, A., Shekouh, A., Larsen, P. D., & Dennett, E. R. (2018). Neoadjuvant therapy in rectal cancer: How are we choosing? ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.14935

O'Connor, M., Hooks, D., Webber, M., Shi, B., Morrison, S., Harding, S., & Larsen, P. (2018). Long-term single-center comparison of ICD lead survival: Evidence for premature Linox lead failure. Journal of Cardiovascular Electrophysiology. Advance online publication. doi: 10.1111/jce.13502

Gunawardene, A., Desmond, B., Shekouh, A., Larsen, P., & Dennett, E. (2018). Disease recurrence following surgery for colorectal cancer: Five-year follow-up. New Zealand Medical Journal, 131(1469), 51-58. Retrieved from https://www.nzma.org.nz/journal

Larsen, P. D., Holley, A. S., Sasse, A., Al-Sinan, A., Fairley, S., & Harding, S. A. (2017). Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thrombosis Research, 152, 14-19. doi: 10.1016/j.thromres.2017.02.006

Harding, S. A., Holley, A., Wilkins, B., Fairley, S., Simmonds, M., & Larsen, P. D. (2017). Contemporary antiplatelet therapy in acute coronary syndromes: Are there differences in outcomes and discontinuation between clopidogrel and ticagrelor? Internal Medicine Journal, 47(11), 1298-1305. doi: 10.1111/imj.13595

Roberts, T., Campbell, A., Larsen, P., & Elder, D. (2017). Preterm infants at discharge: Nap polysomnography versus 24-hour oximetry. Acta Paediatrica, 106(111), 1754-1759. doi: 10.1111/apa.13900

Shi, B., Harding, S., & Larsen, P. (2017). Analysis of ECG measures of cardiac repolarization in relation to arrhythmic events in an implantable cardioverter defibrillator population. Annals of Noninvasive Electrocardiology, 22(2), e12390. doi: 10.1111/anec.12390

Holley, A., Pitman, J., Miller, J., Harding, S., & Larsen, P. (2017). Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Journal of Investigative Medicine, 65(5), 919-925. doi: 10.1136/jim-2016-000361

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2017). Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thrombosis Research, 158, 8-15. doi: 10.1016/j.thromres.2017.07.031

de Burlet, K., Lam, A., Larsen, P., & Dennett, E. (2017). Acute abdominal pain: Changes in the way we assess it over a decade. New Zealand Medical Journal, 130(1463), 39-44. Retrieved from https://www.nzma.org.nz/journal

Matsis, K., Holley, A., Al-Sinan, A., Matsis, P., Larsen, P. D., & Harding, S. A. (2017). Differing clinical characteristics between young and older patients presenting with myocardial infarction. Heart, Lung & Circulation, 26(6), 566-571. doi: 10.1016/j.hlc.2016.09.007

Larsen, P. D., Kerr, A. J., Hood, M., Harding, S. A., Hooks, D., Heaven, D., … on behalf of the ANZACS-QI Investigators. (2017). Pacemaker use in New Zealand: Data from the New Zealand Implanted Cardiac Device Registry (ANZACS-QI 15). Heart, Lung & Circulation, 26(3), 235-239. doi: 10.1016/j.hlc.2016.06.1206

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2016). Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy. Thrombosis Research, 148, 89-95. doi: 10.1016/j.thromres.2016.10.026

Fake, A. L., Harding, S. A., Matsis, P. P., & Larsen, P. D. (2016). Pharmacological therapy following acute coronary syndromes in patients with atrial fibrillation: How do we balance ischaemic risk with bleeding risk? New Zealand Medical Journal, 129(1435), 39-49. Retrieved from https://www.nzma.org.nz/journal

Holley, A. S., Miller, J. H., Larsen, P. D., & Harding, S. A. (2016). Relationship between glutathione peroxidase, platelet reactivity, and reactive oxygen species in an acute coronary syndrome population. Annals of Clinical & Laboratory Science, 46(6), 639-644.

Nichol, G., Brown, S. P., Perkins, G. D., Kim, F., Sterz, F., Elrod, J. A. B., … Larsen, P., … Sayre, M. (2016). What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey. Resuscitation, 107, 115-120. doi: 10.1016/j.resuscitation.2016.08.004

Wolbinski, M., Swain, A. H., Harding, S. A., & Larsen, P. D. (2016). Out-of-hospital cardiac arrest patient characteristics: Comparing ventricular arrthymia and pulseless electrical activity. Heart, Lung & Circulation, 25(7), 639-644. doi: 10.1016/j.hlc.2016.02.001

Holley, A., Harding, S., Sasse, A., Miller, J., & Larsen, P. (2016). Reduced glutathione peroxidase activity predicts increased cardiovascular risk following an acute coronary syndrome. International Cardiovascular Forum Journal, 6, 61-65. doi: 10.17987/icfj.v6i0.241

Johnston, J. W., Larsen, P., El-Haddawi, F. H., Fancourt, M. W., Farrant, G. J., Gilkison, W. T. C., … Mosquera, D. A. (2015). Time delays in presentation and treatment of acute scrotal pain in a provincial hospital. ANZ Journal of Surgery, 85(5), 330-333. doi: 10.1111/ans.12601

Larsen, P. D., Johnston, L. R., Holley, A., La Flamme, A., Smyth, L., Chua, E. W., Kennedy, M. A., & Harding, S. A. (2015). Prevalence and significance of CYP2C19*2 and CYP2C19*17 alleles in a New Zealand acute coronary syndrome population. Internal Medicine Journal, 45(5), 537-545. doi: 10.1111/imj.12698

Furniss, G., Shi, B., Jimenez, A., Harding, S. A., & Larsen, P. D. (2015). Cardiac troponin levels following implantable cardioverter defibrillation implantation and testing. Europace, 17(2), 262-266. doi: 10.1093/europace/euu306

Webb, I. G., Yam, S. T., Cooke, R., Aitken, A., Larsen, P. D., & Harding, S. A. (2015). Elevated baseline cardiac troponin levels in the elderly: Another variable to consider? Heart, Lung & Circulation, 24(2), 142-148. doi: 10.1016/j.hlc.2014.07.071

Shi, B., Ferrier, K. A., Sasse, A., Harding, S. A., & Larsen, P. D. (2014). Correlation between vectorcardiographic measures and cardiac magnetic resonance imaging of the left ventricle in an implantable cardioverter defibrillator population. Journal of Electrocardiology, 47(1), 52-58. doi: 10.1016/j.jelectrocard.2013.06.018

Ady Wirawan, I. M., Wu, R., Abernethy, M., Aldington, S., & Larsen, P. D. (2014). Calcium scores in the risk assessment of an asymptomatic population: Implications for airline pilots. Aviation, Space, & Environmental Medicine, 85(8), 812-817. doi: 10.3357/ASEM.3904.2014

Harding, S. A., Shah, N., Briggs, N., Sasse, A., & Larsen, P. D. (2013). Complex transradial percutaneous coronary intervention using a sheathless guide catheter. Heart, Lung & Circulation, 22(3), 188-192. doi: 10.1016/j.hlc.2012.10.004

Johnston, L. R., Larsen, P. D., La Flamme, A. C., & Harding, S. A. (2013). Methodological considerations for the assessment of ADP induced platelet aggregation using the Multiplate® analyser. Platelets, 24(4), 303-307. doi: 10.3109/09537104.2012.694086

Shi, B., Harding, S. A., Jimenez, A., & Larsen, P. D. (2013). Standard 12-lead electrocardiography measures predictive of increased appropriate therapy in implantable cardioverter defibrillator recipients. Europace, 15(6), 892-898. doi: 10.1093/europace/eus360

Ady Wirawan, I. M., Aldington, S., Griffiths, R. F., Ellis, C. J., & Larsen, P. D. (2013). Cardiovascular investigations of airline pilots with excessive cardiovascular risk. Aviation, Space, & Environmental Medicine, 84(6), 608-612. doi: 10.3357/ASEM.3465.2013

Fake, A. L., Swain, A. H., & Larsen, P. D. (2013). Survival from out-of-hospital cardiac arrest in Wellington in relation to socioeconomic status and arrest location. New Zealand Medical Journal, 126(1376). Retrieved from http://www.nzma.org.nz/journal

Johnston, L. R., Larsen, P. D., La Flamme, A. C., Michel, J. M., Simmonds, M. B., & Harding, S. A. (2013). Suboptimal response to clopidogrel and the effect of prasugrel in acute coronary syndromes. International Journal of Cardiology, 167(3), 995-999. doi: 10.1016/j.ijcard.2012.03.080

Tomkins, W. G. O., Swain, A. H., Bailey, M., & Larsen, P. D. (2013). Beyond the pre-shock pause: The effect of prehospital defibrillation mode on CPR interruptions and return of spontaneous circulation. Resuscitation, 84, 575-579. doi: 10.1016/j.resuscitation.2012.12.018

Elder, D. E., Larsen, P. D., Campbell, A. J., & Galletly, D. C. (2012). Cardioventilatory coupling and inter-breath variability in children referred for polysomnography. Respiratory Physiology & Neurobiology, 181(1), 1-7. doi: 10.1016/j.resp.2012.01.006

Swain, A. H., Al-Salami, M., Larsen, P. D., & Hoyle, S. R. (2012). Patient satisfaction and outcome using emergency care practitioners in New Zealand. Emergency Medicine Australasia, 24(2), 175-180. doi: 10.1111/j.1742-6723.2011.01525.x

Hoyle, S., Swain, A. H., Fake, P., & Larsen, P. D. (2012). Introduction of an extended care paramedic model in New Zealand. Emergency Medicine Australasia, 24(6), 652-656. doi: 10.1111/j.1742-6723.2012.01608.x

Zaidi, M. A., Griffiths, R. F., Larsen, P. D., Newson-Smith, M., & Zaidi, M. A. (2012). The reporting of blood and body fluid exposure and follow-up practices in a tertiary care hospital in the United Arab Emirates. Ibnosina Journal of Medicine & Biomedical Sciences, 4(3), 84-89.

Myers, J. A., Psirides, A., Hathaway, K., & Larsen, P. D. (2012). Air transport by the Wellington Flight Service: A descriptive analysis of interhospital transfers over a 5-year period in the Wellington region of New Zealand. New Zealand Medical Journal, 125(1351). Retrieved from http://www.nzma.org.nz/journal

Sykes, A. J., Larsen, P. D., Griffiths, R. F., & Aldington, S. (2012). A study of airline pilot morbidity. Aviation, Space, & Environmental Medicine, 83(10), 1001-1005. doi: 10.3357/asem.3380.2012

Wilson, D., Harding, S. A., Melton, I., Lever, N. A., Stiles, M. K., Boddington, D., Heald, S., & Larsen, P. D. (2012). Geographic, ethnic and socioeconomic factors influencing access to implantable cardioverter defibrillators (ICDs) in New Zealand. Heart, Lung & Circulation, 21(9), 576-581. doi: 10.1016/j.hlc.2012.04.012

More publications...