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Associate Professor Peter Larsen

Peter Larsen Thumbnail

BSc(Hons), PhD (Otago)

Background

After completing a BSc with Honours at Victoria University of Wellington, I undertook a PhD at the University of Otago. This focused on understanding the interactions between cardiovascular and respiratory control. I then did a postdoctoral fellowship at Michigan State University examined neural control of the cardiovascular system, before returning to the University of Otago, Wellington.

My research interests are now in clinical cardiovascular medicine, including the use of biomarkers in risk stratification, acute myocardial infarction, use of implanted cardiac devices and personalized approaches to clinical care. Application of cardiovascular physiology to clinical questions remains an area of interest for me. In addition, I am involved in supporting registrar research activities in a range of clinical settings.

Contact details

Department of Surgery & Anaesthesia
University of Otago, Wellington
PO Box 7343
Wellington South

Email peter.larsen@otago.ac.nz

Associate Professor Larsen's Health Sciences database profile page

Current roles

  • Head of Department, Surgery and Anaesthesia
  • Head of Department, Radiation Therapy
  • Co-Director, Wellington Cardiovascular Research Group
  • Course Director, Medical Technology Programme

Research expertise

  • Acute Coronary Syndromes
  • Biomarkers in Clinical Cardiology
  • Sudden Cardiac Death
  • Defibrillation
  • Implantable Cardioverter Defibrillators
  • Heart Rate Variability
  • Respiratory Variability
  • Quality Improvement in Clinical Care
  • Clinical Cancer Research

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Publications

Chadwick, K., Larsen, P., & Dungey, G. (2023). Planning experience of new graduate radiation therapists in New Zealand. Journal of Medical Radiation Sciences. Advance online publication. doi: 10.1002/jmrs.661

Sik, A., Kaveney-Gibb, B., Cooper, J., Pearson, J., Larsen, P., & Rogan, A. (2022). Is the Sport Concussion Assessment Tool 5th Edition a useful concussion assessment tool in head-injured patients presenting to the emergency department? Emergency Medicine Australasia. Advance online publication. doi: 10.1111/1742-6723.14144

McTavish, A., Larsen, P., Rogan, A., Carlin, E., Lynch, M., & Peckler, B. (2022). Exploring the feasibility of smartglass facilitated remote supervision in the emergency department: A simulation study [Short report]. Emergency Medicine Australasia. Advance online publication. doi: 10.1111/1742-6723.14142

Rogan, A., Sik, A., Dickinson, E., Patel, V., Peckler, B., McQuade, D., Larsen, P. D., endorsed by ACEM Emergency Department Epidemiology Network. (2022). Diagnostic performance of S100B as a rule-out test for intracranial pathology in head-injured patients presenting to the emergency department who meet NICE Head Injury Guideline criteria for CT-head scan. Emergency Medicine Journal. Advance online publication. doi: 10.1136/emermed-2022-212549

Balfe, J., Rogan, A., & Larsen, P. (2022). Serum levels of S100B are significantly correlated with injury severity. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 81). Retrieved from https://www.queenstownresearchweek.org

Chadwick, K., Larsen, P., & Dungey, G. (2023). Planning experience of new graduate radiation therapists in New Zealand. Journal of Medical Radiation Sciences. Advance online publication. doi: 10.1002/jmrs.661

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Bird, G. K., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2022). Examining variation and temporal dynamics of extracellular matrix biomarkers following acute myocardial infarction. Biomarkers in Medicine, 16(3), 147-161. doi: 10.2217/bmm-2021-0531

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Shi, B., Harding, S. A., & Larsen, P. D. (2022). Cluster analysis of extracellular matrix biomarkers predicts the development of impaired systolic function within 1 year of acute myocardial infarction. Heart & Vessels. Advance online publication. doi: 10.1007/s00380-022-02118-8

Journal - Research Article

Rogan, A., Brunton-O'Sullivan, M., Holley, A., McQuade, D. d., & Larsen, P. (2022). Can serum biomarkers be used to rule out significant intracranial pathology in emergency department patients with mild traumatic brain injury? A systemic review & meta-analysis. Injury, 53, 259-271. doi: 10.1016/j.injury.2021.10.015

Journal - Research Article

Rogan, A., Patel, V., Birdling, J., Lockett, J., Simmonds, H., McQuade, D., & Larsen, P. (2022). Acute traumatic brain injury and the use of head computed tomography scans in the emergency department. Trauma, 24(4), 327-336. doi: 10.1177/14604086211023646

Journal - Research Article

Rogan, A., Sik, A., Dickinson, E., Patel, V., Peckler, B., McQuade, D., Larsen, P. D., endorsed by ACEM Emergency Department Epidemiology Network. (2022). Diagnostic performance of S100B as a rule-out test for intracranial pathology in head-injured patients presenting to the emergency department who meet NICE Head Injury Guideline criteria for CT-head scan. Emergency Medicine Journal. Advance online publication. doi: 10.1136/emermed-2022-212549

Journal - Research Article

Sik, A., Kaveney-Gibb, B., Cooper, J., Pearson, J., Larsen, P., & Rogan, A. (2022). Is the Sport Concussion Assessment Tool 5th Edition a useful concussion assessment tool in head-injured patients presenting to the emergency department? Emergency Medicine Australasia. Advance online publication. doi: 10.1111/1742-6723.14144

Journal - Research Article

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2022). Increased levels of low density neutrophils (LDNs) in myocardial infarction. Acta Cardiologica. Advance online publication. doi: 10.1080/00015385.2021.2015145

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Hally, K. E., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2021). A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction. Scientific Reports, 11, 12705. doi: 10.1038/s41598-021-92108-z

Journal - Research Article

Gunawardene, A., Manning, S., Holley, A., Kristono, G., Danielson, K., Shekouh, A., Larsen, P., & Dennett, E. (2021). An IL8-CEA combined score is stage-specific in colorectal cancer. Surgery, Gastroenterology & Oncology, 26(4), 284-290. doi: 10.21614/sgo-26-4-401

Journal - Research Article

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis, 121, 1637-1649. doi: 10.1055/s-0041-1728763

Journal - Research Article

Marsters, B., Shi, B., Wheeler, B. J., Boucher, S., Macaulay, G., Galland, B., Elder, D., Larsen, P., & Wiltshire, E. (2021). Advanced ECG analysis of cardiac function in children and adolescents with type 1 diabetes: A pilot study. Acta Diabetologica, 58, 1119-1122. doi: 10.1007/s00592-021-01704-y

Journal - Research Article

Mouat, M., Gunawardene, A., Sweetman, L., Dennett, E., & Larsen, P. (2021). Psoas muscle cross-sectional area and outcomes following colorectal cancer surgery. British Journal of Surgical Science, 1(2), 39-45.

Journal - Research Article

Rogan, A., Patel, V., Birdling, J., Lockett, J., Simmonds, H., McQuade, D., Quigley, P., & Larsen, P. (2021). Alcohol and acute traumatic brain injury in the emergency department. Emergency Medicine Australasia, 33, 718-727. doi: 10.1111/1742-6723.13726

Journal - Research Article

Ady Wirawan, I. M., Griffiths, R. F., & Larsen, P. D. (2020). Cardiovascular risk factor modification in asymptomatic adults and implications for pilots. Journal of UOEH, 42(2), 187-201. doi: 10.7888/juoeh.42.187

Journal - Research Article

de Burlet, K. J., Desmond, B., Matsis, R., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2020). Reducing length of stay for patients presenting to general surgery with acute non-surgical abdominal pain. ANZ Journal of Surgery, 90, 2259-2263. doi: 10.1111/ans.16276

Journal - Research Article

Foo, F. S., Lee, M., Looi, K.-L., Larsen, P., Clare, G. C., Heaven, D., … on behalf of the ANZACS-QI investigators. (2020). Implantable cardioverter defibrillator and cardiac resynchronization therapy use in New Zealand (ANZACS-QI 33). Journal of Arrhythmia, 36, 153-163. doi: 10.1002/joa3.12244

Journal - Research Article

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2020). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica, 75(6), 497-502. doi: 10.1080/00015385.2019.1611189

Journal - Research Article

Kane, P., Larsen, P., & Wiltshire, E. (2020). Early identification of cardiac autonomic neuropathy using complexity analysis in children with type 1 diabetes. Journal of Paediatrics & Child Health, 56, 786-790. doi: 10.1111/jpc.14745

Journal - Research Article

Kristono, G. A., Holley, A. S., Hally, K. E., Brunton-O'Sullivan, M. M., Shi, B., Harding, S. A., & Larsen, P. D. (2020). An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction. Cytokine: X, 2, 100037. doi: 10.1016/j.cytox.2020.100037

Journal - Research Article

Kristono, G. A., Holley, A. S., Harding, S. A., & Larsen, P. D. (2020). White blood cell subtypes as predictors of adverse cardiac events. Coronary Artery Disease, 31(5), 446-450. doi: 10.1097/mca.0000000000000860

Journal - Research Article

Kristono, G. A., Holley, A. S., Lakshman, P., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2020). Association between inflammatory cytokines and long-term adverse outcomes in acute coronary syndromes: A systematic review. Heliyon, 6(4), e03704. doi: 10.1016/j.heliyon.2020.e03704

Journal - Research Article

Bond, E. C., Phillips, P., Larsen, P. D., Hunt, L., & Willoughby, R. (2019). Long-term hip function in slipped capital femoral epiphysis treated with in situ pinning. Journal of Orthopaedic Surgery, 27(1), 1-6. doi: 10.1177/2309499018822234

Journal - Research Article

de Burlet, K. J., Lam, A. B. M., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2019). Can surgical registrars accurately identify the urgent from the non-urgent patient presenting with acute abdominal pain? European Surgical Research, 60(1-2), 24-30. doi: 10.1159/000496021

Journal - Research Article

Foo, F. S., Lee, M., Heaven, D., Lever, N., Sinclair, S., Stiles, M. K., Harding, S., … Larsen, P., … on behalf of the ANZACS-QI investigators. (2019). Completeness of ANZACS-QI Cardiac Implanted DEVICE Registry and agreement with national datasets: ANZACS-QI 30. New Zealand Medical Journal, 132(1500), 40-49. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hally, K. E., Bird, G. K., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation. PLoS ONE, 14(10), e0223444. doi: 10.1371/journal.pone.0223444

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: Results of a randomized, cross-over trial. Platelets, 30(5), 599-607. doi: 10.1080/09537104.2018.1479520

Journal - Research Article

Hancock, D. S., Sharplin, P. K., Larsen, P. D., & Phillips, F. T. S. (2019). Early radiological and functional outcomes for a cementless press-fit design modular femoral stem revision system. HIP International, 29(1), 35-40. doi: 10.1177/1120700018760277

Journal - Research Article

Tinawi, G., Gunawardene, A., Shekouh, A., Larsen, P. D., & Dennett, E. R. (2019). Neoadjuvant therapy in rectal cancer: How are we choosing? ANZ Journal of Surgery, 89, 68-73. doi: 10.1111/ans.14935

Journal - Research Article

Wilkins, B., Hullikunte, S., Simmonds, M., Sasse, A., Larsen, P., & Harding, S. A. (2019). Improving the prescribing gap for guideline recommended medications post myocardial infarction. Heart, Lung & Circulation, 28(2), 257-262. doi: 10.1016/j.hlc.2017.10.025

Journal - Research Article

Ady Wirawan, I. M., Griffiths, R. F., & Larsen, P. D. (2018). Cardiovascular tests for risk assessment in asymptomatic adults and implications for pilots. Aerospace Medicine & Human Performance, 89(7), 648-656. doi: 10.3357/amhp.5065.2018

Journal - Research Article

de Burlet, K. J., Desmond, B., Harper, S. J., Larsen, P. D., & Dennett, E. R. (2018). Patients requiring an acute operation: Where are the delays in the process? ANZ Journal of Surgery, 88, 865-869. doi: 10.1111/ans.14718

Journal - Research Article

de Burlet, K. J., MacKay, M., Larsen, P., & Dennett, E. R. (2018). Appropriateness of CT scans for patients with non-traumatic acute abdominal pain. British Journal of Radiology, 91(1088), 20180158. doi: 10.1259/bjr.20180158

Journal - Research Article

Gunawardene, A., Desmond, B., Shekouh, A., Larsen, P., & Dennett, E. (2018). Disease recurrence following surgery for colorectal cancer: Five-year follow-up. New Zealand Medical Journal, 131(1469), 51-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Gunawardene, A., Larsen, P., Shekouh, A., & Dennett, E. (2018). Pre-operative carcinoembryonic antigen predicts survival following colorectal cancer surgery with curative intent. ANZ Journal of Surgery, 88, 1311-1315. doi: 10.1111/ans.14723

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). Platelets regulate leucocyte responses to Toll-like receptor stimulation. Clinical & Translational Immunology, 7, e1036. doi: 10.1002/cti2.1036

Journal - Research Article

Hancock, D. S., Rupasinghe, S. L., Elkinson, I., Bloomfield, M. G., & Larsen, P. D. (2018). Benzoyl peroxide + chlorhexidine versus chlorhexidine alone skin preparation to reduce Propionibacterium acnes: A randomized controlled trial. ANZ Journal of Surgery, 88, 1182-1186. doi: 10.1111/ans.14848

Journal - Research Article

O'Connor, M., Hooks, D., Webber, M., Shi, B., Morrison, S., Harding, S., & Larsen, P. (2018). Long-term single-center comparison of ICD lead survival: Evidence for premature Linox lead failure. Journal of Cardiovascular Electrophysiology, 29(7), 1024-1031. doi: 10.1111/jce.13502

Journal - Research Article

de Burlet, K., Lam, A., Larsen, P., & Dennett, E. (2017). Acute abdominal pain: Changes in the way we assess it over a decade. New Zealand Medical Journal, 130(1463), 39-44. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2017). Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thrombosis Research, 158, 8-15. doi: 10.1016/j.thromres.2017.07.031

Journal - Research Article

Harding, S. A., Holley, A., Wilkins, B., Fairley, S., Simmonds, M., & Larsen, P. D. (2017). Contemporary antiplatelet therapy in acute coronary syndromes: Are there differences in outcomes and discontinuation between clopidogrel and ticagrelor? Internal Medicine Journal, 47(11), 1298-1305. doi: 10.1111/imj.13595

Journal - Research Article

Holley, A., Pitman, J., Miller, J., Harding, S., & Larsen, P. (2017). Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Journal of Investigative Medicine, 65(5), 919-925. doi: 10.1136/jim-2016-000361

Journal - Research Article

Larsen, P. D., Holley, A. S., Sasse, A., Al-Sinan, A., Fairley, S., & Harding, S. A. (2017). Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thrombosis Research, 152, 14-19. doi: 10.1016/j.thromres.2017.02.006

Journal - Research Article

Larsen, P. D., Kerr, A. J., Hood, M., Harding, S. A., Hooks, D., Heaven, D., … on behalf of the ANZACS-QI Investigators. (2017). Pacemaker use in New Zealand: Data from the New Zealand Implanted Cardiac Device Registry (ANZACS-QI 15). Heart, Lung & Circulation, 26(3), 235-239. doi: 10.1016/j.hlc.2016.06.1206

Journal - Research Article

Matsis, K., Holley, A., Al-Sinan, A., Matsis, P., Larsen, P. D., & Harding, S. A. (2017). Differing clinical characteristics between young and older patients presenting with myocardial infarction. Heart, Lung & Circulation, 26(6), 566-571. doi: 10.1016/j.hlc.2016.09.007

Journal - Research Article

Roberts, T., Campbell, A., Larsen, P., & Elder, D. (2017). Preterm infants at discharge: Nap polysomnography versus 24-hour oximetry. Acta Paediatrica, 106(111), 1754-1759. doi: 10.1111/apa.13900

Journal - Research Article

Shi, B., Harding, S., & Larsen, P. (2017). Analysis of ECG measures of cardiac repolarization in relation to arrhythmic events in an implantable cardioverter defibrillator population. Annals of Noninvasive Electrocardiology, 22(2), e12390. doi: 10.1111/anec.12390

Journal - Research Article

Fake, A. L., Harding, S. A., Matsis, P. P., & Larsen, P. D. (2016). Pharmacological therapy following acute coronary syndromes in patients with atrial fibrillation: How do we balance ischaemic risk with bleeding risk? New Zealand Medical Journal, 129(1435), 39-49. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2016). Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy. Thrombosis Research, 148, 89-95. doi: 10.1016/j.thromres.2016.10.026

Journal - Research Article

Holley, A. S., Miller, J. H., Larsen, P. D., & Harding, S. A. (2016). Relationship between glutathione peroxidase, platelet reactivity, and reactive oxygen species in an acute coronary syndrome population. Annals of Clinical & Laboratory Science, 46(6), 639-644.

Journal - Research Article

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