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Health Sciences staff profiles

Dr Trudy Milne

PositionSenior Research Fellow
QualificationsNZCS PhD
Research summaryOral health

Research

Dr Milne's research continues in a number of oral health areas including endodontics, periodontology and orthodontics.

Investigation of periodontopathogens and their association with angiogenic and inflammatory gene expression in dental pulp continues with the hope of improved dental treatment outcomes for smokers and patients with Type 2 diabetes. A study of a grafting material in a bone-healing sheep model and the genes associated with osteogenesis aims to advance the development of implant options for dental patients.

Dr Milne is also investigating the role osteoblasts and periodontal ligament cells play in the immune response and bone remodelling during orthodontic tooth movement.

Publications

Itskovich, Y., Meikle, M. C., Cannon, R. D., Farella, M., Coates, D. E., & Milne, T. J. (2021). Differential behaviour and gene expression in 3D cultures of femoral- and calvarial-derived human osteoblasts under a cyclic compressive mechanical load. European Journal of Oral Sciences. Advance online publication. doi: 10.1111/eos.12818

James, J. E., Lamping, E., Santhanam, J., Milne, T. J., Razak, M. F. A., Zakaria, L., & Cannon, R. D. (2020). A 23 bp cyp51A promoter deletion associated with voriconazole resistance in clinical and environmental isolates of Neocosmospora keratoplastica. Frontiers in Microbiology, 11, 272. doi: 10.3389/fmicb.2020.00272

Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681

McLaughlin, K. I., Milne, T. J., Zafar, S., Zanicotti, D. G., Cullinan, M. P., Seymour, G. J., & Coates, D. E. (2020). The in vitro effect of VEGF receptor inhibition on primary alveolar osteoblast nodule formation. Australian Dental Journal, 65, 196-204. doi: 10.1111/adj.12752

Reid, P., Heng, N. C. K., Hale, J. D., Krishnan, D., Crane, J., Tagg, J. R., & Milne, T. J. (2020). A TaqMan™-based quantitative PCR screening assay for the probiotic Streptococcus salivarius K12 based on the specific detection of its megaplasmid-associated salivaricin B locus [Note]. Journal of Microbiological Methods, 170, 105837. doi: 10.1016/j.mimet.2020.105837

Coates, D. E., Zafar, S., & Milne, T. J. (2017). Quantitative real-time gene profiling of human alveolar osteoblasts. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 447-459). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_27

Chapter in Book - Research

Milne, T. J. (2017). A protocol for the determination of the methylation status of gingival tissue DNA at specific CpG islands. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 299-306). New York, NY: Humana Press. doi: 10.1007/978-1-4939-6685-1_17

Chapter in Book - Research

Chou, P., & Milne, T. J. (2010). Real-time PCR focused-gene array profiling of gingival and periodontal ligament fibroblasts. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 373-383). New York: Springer. doi: 10.1007/978-1-60761-820-1_23

Chapter in Book - Research

Itskovich, Y., Meikle, M. C., Cannon, R. D., Farella, M., Coates, D. E., & Milne, T. J. (2021). Differential behaviour and gene expression in 3D cultures of femoral- and calvarial-derived human osteoblasts under a cyclic compressive mechanical load. European Journal of Oral Sciences. Advance online publication. doi: 10.1111/eos.12818

Journal - Research Article

Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681

Journal - Research Article

James, J. E., Lamping, E., Santhanam, J., Milne, T. J., Razak, M. F. A., Zakaria, L., & Cannon, R. D. (2020). A 23 bp cyp51A promoter deletion associated with voriconazole resistance in clinical and environmental isolates of Neocosmospora keratoplastica. Frontiers in Microbiology, 11, 272. doi: 10.3389/fmicb.2020.00272

Journal - Research Article

McLaughlin, K. I., Milne, T. J., Zafar, S., Zanicotti, D. G., Cullinan, M. P., Seymour, G. J., & Coates, D. E. (2020). The in vitro effect of VEGF receptor inhibition on primary alveolar osteoblast nodule formation. Australian Dental Journal, 65, 196-204. doi: 10.1111/adj.12752

Journal - Research Article

Perry, S. E., Huckabee, M.-L., Tompkins, G., & Milne, T. (2020). The association between oral bacteria, the cough reflex and pneumonia in patients with acute stroke and suspected dysphagia. Journal of Oral Rehabilitation, 47, 386-394. doi: 10.1111/joor.12903

Journal - Research Article

Al-Hassiny, A., Hussani, H., Milne, T., Seo, B., Rich, A. M., & Friedlander, L. T. (2019). Vascularity and angiogenic signaling in the dentine-pulp complex of immature and mature permanent teeth. European Endodontic Journal, 4(2), 80-85. doi: 10.14744/eej.2019.26349

Journal - Research Article

Al-Dujaili, M., Milne, T. J., Cannon, R. D., & Farella, M. (2018). Postnatal expression of chondrogenic and osteogenic regulatory factor mRNA in the rat condylar cartilage. Archives of Oral Biology, 93, 126-132. doi: 10.1016/j.archoralbio.2018.05.019

Journal - Research Article

Hidayat, M. F. H., Milne, T., Cullinan, M. P., & Seymour, G. J. (2018). Feasibility of the salivary transcriptome as a novel biomarker in determining disease susceptibility. Journal of Periodontal Research, 53(3), 369-377. doi: 10.1111/jre.12522

Journal - Research Article

Parachuru, V. P. B., Coates, D. E., Milne, T. J., Rich, A. M., & Seymour, G. J. (2018). FoxP3+ regulatory T cells, interleukin 17 and mast cells in chronic inflammatory periodontal disease. Journal of Periodontal Research, 53(4), 622-635. doi: 10.1111/jre.12552

Journal - Research Article

Avadhani, A. V., Parachuru, V. P. B., Milne, T., Seymour, G. J., & Rich, A. M. (2017). Multiple cells express interleukin 17 in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 46(1), 39-45. doi: 10.1111/jop.12465

Journal - Research Article

Hasmun, N. N. b., Drummond, B. K., Milne, T., Cullinan, M. P., Meldrum, A. M., & Coates, D. (2017). Effects of environmental tobacco smoke on the oral health of preschool children. European Archives of Paediatric Dentistry, 18(6), 393-398. doi: 10.1007/s40368-017-0308-6

Journal - Research Article

Balaji, K., Milne, T. J., Drummond, B. K., Cullinan, M. P., & Coates, D. E. (2016). A comparison of salivary IgA in children with Down syndrome and their family members. Archives of Oral Biology, 67, 39-45. doi: 10.1016/j.archoralbio.2016.03.005

Journal - Research Article

Bisanz, J. E., Suppiah, P., Thomson, W. M., Milne, T., Yeoh, N., Nolan, A., … Cullinan, M. P., & Stebbings, S. M. (2016). The oral microbiome of patients with axial spondyloarthritis compared to healthy individuals. PeerJ, 4, e2095. doi: 10.7717/peerj.2095

Journal - Research Article

Javvadi, L. R., Parachuru, V. P. B., Milne, T. J., Seymour, G. J., & Rich, A. M. (2016). Regulatory T-cells and IL17A+ cells infiltrate oral lichen planus lesions. Pathology, 48(6), 564-573. doi: 10.1016/j.pathol.2016.06.002

Journal - Research Article

Milne, T. J., Coates, D. E., Leichter, J. W., Soo, L., Williams, S. M., Seymour, G. J., & Cullinan, M. P. (2016). Periodontopathogen levels following the use of an Er:YAG laser in the treatment of chronic periodontitis. Australian Dental Journal, 61, 35-44. doi: 10.1111/adj.12306

Journal - Research Article

Ohlrich, E. J., Coates, D. E., Cullinan, M. P., Milne, T. J., Zafar, S., Zhao, Y., Duncan, W. J., & Seymour, G. J. (2016). The bisphosphonate zoledronic acid regulates key angiogenesis-related genes in primary human gingival fibroblasts. Archives of Oral Biology, 63, 7-14. doi: 10.1016/j.archoralbio.2015.11.013

Journal - Research Article

Siddiqi, A., Milne, T., Cullinan, M. P., & Seymour, G. J. (2016). Analysis of P. gingivalis, T. forsythia and S. aureus levels in edentulous mouths prior to and 6 months after placement of one-piece zirconia and titanium implants. Clinical Oral Implants Research, 27, 288-294. doi: 10.1111/clr.12536

Journal - Research Article

Sinon, S. H., Rich, A. M., Parachuru, V. P. B., Firth, F. A., Milne, T., & Seymour, G. J. (2016). Downregulation of toll-like receptor-mediated signalling pathways in oral lichen planus. Journal of Oral Pathology & Medicine, 45, 28-34. doi: 10.1111/jop.12319

Journal - Research Article

Zafar, S., Coates, D. E., Cullinan, M. P., Drummond, B. K., Milne, T., & Seymour, G. J. (2016). Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts. Clinical Oral Investigations, 20(8), 2023-2035. doi: 10.1007/s00784-015-1706-y

Journal - Research Article

Parachuru, V. P. B., Coates, D. E., Milne, T. J., Hussaini, H. M., Rich, A. M., & Seymour, G. J. (2014). Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease. Journal of Periodontal Research, 49(6), 817-826. doi: 10.1111/jre.12169

Journal - Research Article

Zafar, S., Coates, D. E., Cullinan, M. P., Drummond, B. K., Milne, T., & Seymour, G. J. (2014). Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts. Journal of Oral Pathology & Medicine, 43, 711-721. doi: 10.1111/jop.12181

Journal - Research Article

Saminathan, A., Vinoth, K. J., Wescott, D. C., Pinkerton, M. N., Milne, T. J., Cao, T., & Meikle, M. C. (2012). The effect of cyclic mechanical strain on the expression of adhesion-related genes by periodontal ligament cells in two-dimensional culture. Journal of Periodontal Research, 47(2), 212-221. doi: 10.1111/j.1600-0765.2011.01423.x

Journal - Research Article

Milne, T. J., Ichim, I., Patel, B., McNaughton, A., & Meikle, M. C. (2009). Induction of osteopenia during experimental tooth movement in the rat: Alveolar bone remodelling and the mechanostat theory. European Journal of Orthodontics, 31(3), 221-231. doi: 10.1093/ejo/cjp032

Journal - Research Article

Pinkerton, M. N., Wescott, D. C., Gaffey, B. J., Beggs, K. T., Milne, T. J., & Meikle, M. C. (2008). Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation. Journal of Periodontal Research, 43(3), 343-351. doi: 10.1111/j.1600-0765.2007.01040.x

Journal - Research Article

Wescott, D. C., Pinkerton, M. N., Gaffey, B. J., Beggs, K. T., Milne, T. J., & Meikle, M. C. (2007). Osteogenic gene expression by human periodontal ligament cells under cyclic tension. Journal of Dental Research, 86(12), 1212-1216.

Journal - Research Article

Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278(33), 31105-31110.

Journal - Research Article

Abbenante, G., Leung, D., Bond, T., & Fairlie, D. P. (2001). An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilides. Letters in Peptide Science, 7, 347-351.

Journal - Research Article

Lewis, R. J., Nielsen, K. J., Craik, D. J., Loughnan, M. L., Adams, D. A., Sharpe, I. A., … Bond, T., … Alewood, P. F. (2000). Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. Journal of Biological Chemistry, 275(45), 35335-35344.

Journal - Research Article

Reid, P., Heng, N. C. K., Hale, J. D., Krishnan, D., Crane, J., Tagg, J. R., & Milne, T. J. (2020). A TaqMan™-based quantitative PCR screening assay for the probiotic Streptococcus salivarius K12 based on the specific detection of its megaplasmid-associated salivaricin B locus [Note]. Journal of Microbiological Methods, 170, 105837. doi: 10.1016/j.mimet.2020.105837

Journal - Research Other

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