Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x
Journal - Research Article
Niimi, K., Woods, M. A., Maki, K., Nakayama, H., Hatakenaka, K., Chibana, H., … Niimi, M., Cannon, R. D., & Monk, B. C. (2012). Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. Journal of Antimicrobial Chemotherapy, 67(7), 1666-1676. doi: 10.1093/jac/dks112
Journal - Research Article
Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., … Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/dkq073
Journal - Research Article
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., … Niimi, M., … Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/cmr.00051-08
Journal - Research Article
Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., & Cannon, R. D. (2006). Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility. Antimicrobial Agents & Chemotherapy, 50(4), 1148-1155.
Journal - Research Article
Lamping, E., Monk, B. C., Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., … Cannon, R. D. (2007). Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryotic Cell, 6(7), 1150-1165.
Journal - Research Article
Holmes, A. R., Tsao, S., Ong, S.-W., Lamping, E., Niimi, K., Monk, B. C., Niimi, M., … Cannon, R. D. (2006). Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2. Molecular Microbiology, 62(1), 170-186.
Journal - Research Article
Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08
Journal - Research Article
Holmes, A. R., Lin, Y.-H., Niimi, K., Lamping, E., Keniya, M., Niimi, M., … Monk, B. C., & Cannon, R. D. (2008). ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrobial Agents & Chemotherapy, 52(11), 3851-3862. doi: 10.1128/AAC.00463-08
Journal - Research Article
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., & Monk, B. C. (2007). Candida albicans drug resistance: Another way to cope with stress. Microbiology, 153, 3211-3217.
Journal - Research Article
Holmes, A. R., Tsao, S., Lamping, E., Niimi, K., Monk, B. C., Tanabe, K., Niimi, M., & Cannon, R. D. (2006). Amino acid residues affecting drug pump function in Candida albicans: C. albicans drug pump function [Review]. Nippon Ishinkin Gakkai Zasshi, 47(4), 275-281.
Journal - Research Other
Niimi, K., & Niimi, M. (2009). The mechanisms of resistance to echinocandin class of antifungal drugs [Article in Japanese]. Nippon Ishinkin Gakkai Zasshi, 50(2), 57-66.
Journal - Research Article
Hayama, K., Ishibashi, H., Ishijima, S. A., Niimi, K., Tansho, S., Ono, Y., Monk, B. C., Holmes, A. R., … Cannon, R. D., & Abe, S. (2012). A D-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model. FEMS Microbiology Letters, 328(2), 130-137. doi: 10.1111/j.1574-6968.2011.02490.x
Journal - Research Article
Niimi, K., Lamping, E., Niimi, M., & Cannon, R. D. (2012). Dissection of C-albicans ABC transporter Cdr1p: Large intracellular and extracellular loops are critical structural and functional elements. Mycoses, 55(Suppl. 4), (pp. 335). doi: 10.1111/j.1439-0507.2012.02206.x
Conference Contribution - Published proceedings: Abstract
Cannon, R. D., Lamping, E., Niimi, K., Holmes, A. R., Monk, B. C., & Niimi, M. (2009). Functional expression of human ABCB1 in Saccharomyces cerevisiae. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Conference Contribution - Published proceedings: Abstract
Kajiwara, S., Honda, T., Oura, T., Lamping, E., Keniya, M. V., Niimi, K., Niimi, M., Holmes, A. R., Monk, B. C., & Cannon, R. D. (2008). Alteration of Saccharomyces cerevisiae membrane composition for improved heterologous expression of human transporter ABCB1. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 21). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Poster-Abstracts-NZMS-2008.pdf
Conference Contribution - Published proceedings: Abstract
Niimi, M., Tanabe, K., Niimi, K., Lamping, E., Takano, Y., Holmes, A. R., Monk, B. C., Cannon, R. D., & Uehara, Y. (2008). Characterization of drug efflux pump inhibitors that chemosensitize fungal ABC transporters. Proceedings of the 9th American Society for Microbiology Conference on Candida and Candidiasis. (pp. 50). Washington, DC: ASM. [Abstract]
Conference Contribution - Published proceedings: Abstract
Niimi, K., Monk, B. C., Maki, K., Hatakenaka, K., Ikeda, F., Niimi, M., … Cannon, R. D. (2008). Clinically significant micafungin resistance in Candida glabrata requires mutations in both FKS1 and FKS2. Proceedings of the 9th American Society for Microbiology Conference on Candida and Candidiasis. (pp. 24). Washington, DC: ASM. [Abstract]
Conference Contribution - Published proceedings: Abstract
Holmes, A. R., Raju, S., Uwamahoro, N., Niimi, K., Lamping, E., Keniya, M. V., Monk, B. C., & Cannon, R. D. (2008). Phosphorylation site S312 is important for Candida albicans Cdr1p function. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 18-19). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Oral-Abstracts-NZMS-2008.pdf
Conference Contribution - Published proceedings: Abstract
Niimi, K., Maki, K., Hatakenaka, K., Ishikawa, T., Takata, T., Tamura, K., Niimi, M., … Monk, B. C., & Cannon, R. D. (2007). Clinical micafungin resistance requires functional homozygosity in Candida glabrata glucan synthase. Japanese Journal of Medical Mycology. 48(Suppl. 1), (pp. 69). [Abstract]
Conference Contribution - Published proceedings: Abstract
Holmes, A. R., Lin, Y.-H., Niimi, K., Lamping, E., Monk, B. C., Keniya, M., & Cannon, R. D. (2007). Differential expression and activities of drug efflux proteins Cdr1p and Cdr2p in azole resistant Candida albicans isolates. Proceedings of the Faculty of Dentistry 3M Research Day. Retrieved from http://dentistry.otago.ac.nz/research/rd2007/presentations.html
Conference Contribution - Published proceedings: Abstract
Niimi, K., Monk, B. C., Lamping, E., Holmes, A. R., Niimi, M., Maki, K., & Cannon, R. D. (2007). Echinocandin resistance mechanisms in Candida species. Proceedings of the Faculty of Dentistry 3M Research Day. Retrieved from http://dentistry.otago.ac.nz/research/rd2007/presentations.html
Conference Contribution - Published proceedings: Abstract
Lamping, E., Nakamura, K., Ranchod, A., Holmes, A. R., Niimi, K., Niimi, M., & Cannon, R. D. (2007). Mechanisms of innate azole resistance in Candida krusei. Proceedings of the Faculty of Dentistry 3M Research Day. Retrieved from http://dentistry.otago.ac.nz/research/rd2007/presentations.html
Conference Contribution - Published proceedings: Abstract
Cannon, R. D., Niimi, K., Holmes, A. R., Lamping, E., Keniya, M., Niimi, M., & Monk, B. C. (2007). Overcoming efflux pump-mediated drug resistance in Candida albicans. Journal of Dental Research, 86(Spec Iss A), 0247. Retrieved from http://www.dentalresearch.org
Conference Contribution - Published proceedings: Abstract
Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Cannon, R. D., & Monk, B. C. (2006). Identifying novel aspects of ABC transporter structure and function using surface-active chemosensitizers. Japanese Journal of Medical Mycology. 47(Suppl. 1), (pp. 67). [Abstract]
Conference Contribution - Published proceedings: Abstract
