Associate Professor Nick Heng

2026

Journal - Research Article

Liu, X., Cameron, A. B., Haugli, K. H., Mougios, A. A., Heng, N. C. K., & Choi, J. J. E. (2026). Impact of progressive diamond bur wear on the trueness of subtractively-manufactured lithium disilicate crowns. Digital Dentistry Journal, 3(1), 100088. doi: 10.1016/j.ddj.2026.100088

Alkaff, A. H., Malik, A., Situmeang, P. A., & Heng, N. C. K. (2026). Genetic characteristics associated with probiotic functions in four Indonesian skin microbiome-derived bacterial strains. Microorganisms, 14(1), 248. doi: 10.3390/microorganisms14010248

Journal - Research Other

Wang, X., Aarts, J. M., Heng, N. C. K., Cameron, A. B., & Choi, J. J. E. (2026). Influence of different post-washing parameters on the properties of additively-manufactured dental devices: A systematic review. Journal of Dentistry, 165, 106315. doi: 10.1016/j.jdent.2025.106315

2025

Journal - Research Other

Wang, X., Cameron, A. B., Heng, N. C. K., Aarts, J. M., & Choi, J. J. E. (2025). Occlusal accuracy of digitally manufactured removable dentures: A systematic review of in vitro studies. Journal of Dentistry, 162, 106110. doi: 10.1016/j.jdent.2025.106110

Liu, X., Cameron, A. B., Haugli, K. H., Mougios, A. A., Heng, N. C. K., & Choi, J. J. E. (2025). Accuracy of lithium disilicate and polymer-infiltrated ceramic-network (PICN) ceramic restorations fabricated from subtractive manufacturing: A systematic review of in vitro studies. Journal of Dentistry. Advance online publication. doi: 10.1016/j.jdent.2025.105872

Liu, X., Cameron, A. B., Haugli, K. H., Mougios, A. A., Heng, N. C. K., & Choi, J. J. E. (2025). Influence of CAD/CAM diamond bur wear on the accuracy and surface roughness of dental ceramic restorations: A systematic review. Journal of the Mechanical Behavior of Biomedical Materials, 161, 106813. doi: 10.1016/j.jmbbm.2024.106813

Conference Contribution - Verbal presentation and other Conference outputs

Liu, X., Cameron, A., Haugli, K. H., Mougios, A. A., Heng, N. C. K., & Choi, J. J. E. (2025, September). Are IPS e.max CAD crowns still accurate as diamond burs deteriorate? Verbal presentation at the Faculty of Dentistry Clinical and Research Excellence Symposium, Dunedin, New Zealand.

2024

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N. (2024, December). Microbiology-related practical sessions in the Otago oral health programme: Why they matter. Verbal presentation at the College of Oral Health Academics (COHA) Conference, Auckland, New Zealand.

2023

Edited Book - Research

Seymour, G. J., Cullinan, M. P., Heng, N. C. K., & Cooper, P. R. (Eds.). (2023). Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588) (3rd ed.). New York, NY: Springer, 528p. doi: 10.1007/978-1-0716-2780-8

Chapter in Book - Research

Heng, N. C. K., & Stanton, J.-A. L. (2023). The long and short of genome sequencing: Using a hybrid sequencing strategy to sequence oral microbial genomes. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 75-89). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_6

Journal - Research Article

Christophers, M., Heng, L., & Heng, N. (2023). Nisin E, a new nisin variant produced by Streptococcus equinus MDC1. Applied Sciences, 13, 1186. doi: 10.3390/app13021186

2022

Journal - Research Article

Benn, A. M. L., Heng, N. C. K., Thomson, W. M., & Broadbent, J. M. (2022). Plaque and dental caries risk in mid-life. Caries Research, 56, 464-476. doi: 10.1159/000527255

Ratnayake, J., Veerasamy, A., Ahmed, H., Coburn, D., Loch, C., Gray, A. R., Lyons, K. M., Heng, N. C. K., Cannon, R. D., … Brunton, P. A. (2022). Clinical and microbiological evaluation of a chlorhexidine-modified glass ionomer cement (GIC-CHX) restoration placed using the atraumatic restorative treatment (ART) technique. Materials, 15, 5044. doi: 10.3390/ma15145044

Benn, A. M. L., Heng, N. C. K., Thomson, W. M., Sissons, C. H., Gellen, L. S., Gray, A. R., & Broadbent, J. M. (2022). Associations of sex, oral hygiene and smoking with oral species in distinct habitats at age 32 years. European Journal of Oral Sciences, 130, e12829. doi: 10.1111/eos.12829

Conference Contribution - Published proceedings: Abstract

Heng, N., Stanton, J.-A., & Tompkins, G. (2022). The genetic basis of bacteriocin STH₂ resistance in Streptococcus mitis I18. New Zealand Dental Journal, 118(4), (pp. 176). [Abstract]

2021

Journal - Research Other

Allen, L. L., Heng, N. C. K., & Tompkins, G. R. (2021). Streptococcus salivarius isolates of varying acid tolerance exhibit F₁F₀-ATPase conservation [Brief report]. Caries Research, 55, 288-291. doi: 10.1159/000516175

Conference Contribution - Published proceedings: Abstract

Heng, N., Han, R., Morgan, X., & Loch, C. (2021). The oral microbiome of killer whales (Orcinus orca). Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 134). Retrieved from https://www.faobmb2021.org

2020

Journal - Research Article

Heng, N. C. K., & Stanton, J.-A. L. (2020). Next-generation DNA sequencing of oral microbes at the Sir John Walsh Research Institute: Technologies, tools and achievements. Journal of the Royal Society of New Zealand, 50(1), 91-107. doi: 10.1080/03036758.2019.1687530

Journal - Research Other

Reid, P., Heng, N. C. K., Hale, J. D., Krishnan, D., Crane, J., Tagg, J. R., & Milne, T. J. (2020). A TaqMan™-based quantitative PCR screening assay for the probiotic Streptococcus salivarius K12 based on the specific detection of its megaplasmid-associated salivaricin B locus [Note]. Journal of Microbiological Methods, 170, 105837. doi: 10.1016/j.mimet.2020.105837

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N. (2020, September). Bacteriocins and bacteriocin resistance: A tale of streptococcal genomes [Research presentation]. Verbal presentation at the Combined Faculty of Dentistry's Annual Clinical Excellence Day & Sir John Walsh Research Institute Research Day: Clinical & Research Excellence Spring Webinar Series, [Online].

Heng, N. (2020, December). Experiences of a 'virtual microbiology practical': Zoom-based lectures and online tests. Verbal presentation at the College of Oral Health Academics (COHA) Virtual Conference: Going Viral, [Online].

2019

Journal - Research Article

Sartonoa, G., Rizqiyah, I., Asmarinah, A., Heng, N. C. K., & Malik, A. (2019). Three bacteriocin peptides from a lactic acid bacterium Weissella confusa MBF8-1 with spermicidal activity. Current Pharmaceutical Biotechnology, 20(9), 766-771. doi: 10.2174/1389201020666190617163310

Benic, G. Z., Farella, M., Morgan, X. C., Viswam, J., Heng, N. C., Cannon, R. D., & Mei, L. (2019). Oral probiotics reduce halitosis in patients wearing orthodontic braces: A randomized, triple-blind, placebo-controlled trial. Journal of Breath Research, 13, 036010. doi: 10.1088/1752-7163/ab1c81

Conference Contribution - Published proceedings: Abstract

Heng, N. C. K., Stanton, J.-A. L., Treece, J., Dufour, M., & Tompkins, G. R. (2019). Characterisation of bacteriocin resistance development by Streptococcus mitis strain I18. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 606. Retrieved from https://www.nzmscoference.org.nz

Allen, L., Heng, N., & Tompkins, G. (2019). Streptococcus salivarius isolates of varying acid tolerance display F₁F₀-ATPase conservation. Journal of Dental Research, 98(A), 0830. Retrieved from https://iadr.abstractarchives.com

Heng, N., & Tompkins, G. (2019). Characterization of bacteriocin resistance exhibited by Streptococcus mitis. Journal of Dental Research, 98(A), 1412. Retrieved from https://iadr.abstractarchives.com

Heng, N., Dufour, M., Stanton, J. A., Treece, J., & Tompkins, G. (2019). Characterisation of bacteriocin resistance exhibited by Streptococcus australis strain I18. New Zealand Dental Journal, 115, (pp. 161). [Abstract]

2018

Journal - Research Other

Benn, A. M. L., Heng, N. C. K., Broadbent, J. M., & Thomson, W. M. (2018). Studying the human oral microbiome: Challenges and the evolution of solutions. Australian Dental Journal, 63(1), 14-24. doi: 10.1111/adj.12565

Conference Contribution - Published proceedings: Abstract

Allen, L. L., Heng, N. C. K., & Tompkins, G. R. (2018). Streptococcus salivarius isolates of varying acid tolerance exhibit F₁F₀-ATPase conservation. Proceedings of the New Zealand Microbiological Society (NZMS) & New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 90). Retrieved from https://www.nzmsconference.org.nz

Mei, L., Benic, G., Cannon, R. D., Heng, N., Morgan, X., & Farella, M. (2018). Efficacy of oral probiotics in managing biofilm formation in patients wearing fixed orthodontic appliances. New Zealand Dental Journal, 114(4), (pp. 184-185). [Abstract]

Heng, N. C. K., Hale, J. D. F., Swe, P. M., Power, D. A., & Tagg, J. R. (2018). Dysgalacticin and Sanguinicin K11: Two novel antimicrobial proteins (Bacteriocins) targeting important pathogens. New Zealand Dental Journal, 114(4), (pp. 184). [Abstract]

2017

Edited Book - Research

Seymour, G. J., Cullinan, M. P., & Heng, N. C. K. (Eds.). (2017). Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537) (2nd ed.). New York, NY: Springer, 503p. doi: 10.1007/978-1-4939-6685-1

Journal - Research Article

Grazia, S. E., Sumayyah, S., Haiti, F. S., Sahlan, M., Heng, N. C. K., & Malik, A. (2017). Bacteriocin-like inhibitory substance (BLIS) activity of Streptococcus macedonicus MBF10-2 and its synergistic action in combination with antibiotics. Asian Pacific Journal of Tropical Medicine, 10(12), 1140-1145. doi: 10.1016/j.apjtm.2017.11.001

Heng, N. C. K., Yeh, C.-W., & Malik, A. (2017). Draft genome sequence of Weissella confusa MBF8-1, a glucansucrase- and bacteriocin-producing strain isolated from a homemade soy product. Genome Announcements, 5(4), e01497-16. doi: 10.1128/genomeA.01497-16

Conference Contribution - Published proceedings: Abstract

Parachuru Venkata, A., Drummond, B. K., Meldrum, A., & Heng, N. (2017). Children's oral health-related quality of life five to seven years after comprehensive care under general anaesthesia for early childhood caries. New Zealand Dental Journal, 113(4), (pp. 61). [Abstract]

Heng, N. C. K., & Christophers, M. D. (2017). Characterisation of antimicrobial (bacteriocin) activity produced by Streptococcus equinus MDC1. New Zealand Dental Journal, 113(4), (pp. 55). [Abstract]

Heng, N. C. K., & Christophers, M. D. (2017). Genome sequence analysis of Streptococcus equinus MDC1, a nisin-producing oral isolate of canine origin. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 64. Retrieved from http://www.nzmsconference.org.nz/

Heng, N., & Christophers, M. (2017). Characterization of bacteriocin activity produced by Streptococcus lutetiensis. Journal of Dental Research, 96(Spec. Iss. A), 1726. Retrieved from http://www.iadr.org

2016

Chapter in Book - Research

Hale, J. D. F., Wescombe, P. A., Tagg, J. R., & Heng, N. C. K. (2016). Streptococcal bacteriocin-producing strains as oral probiotic agents. In R. L. Dorit, S. M. Roy & M. A. Riley (Eds.), The bacteriocins: Current knowledge and future prospects. (pp. 103-126). Poole, UK: Caister Academic Press. doi: 10.21775/9781910190371.06

Journal - Research Article

Walker, G. V., Heng, N. C. K., Carne, A., Tagg, J. R., & Wescombe, P. A. (2016). Salivaricin E and abundant dextranase activity may contribute to the anti-cariogenic potential of the probiotic candidate Streptococcus salivarius JH. Microbiology, 162(3), 476-486. doi: 10.1099/mic.0.000237

Malik, A., Sumayyah, S., Yeh, C.-W., & Heng, N. C. K. (2016). Identification and sequence analysis of pWcMBF8-1, a bacteriocin-encoding plasmid from the lactic acid bacterium Weissella confusa. FEMS Microbiology Letters, 363(8), fnw059. doi: 10.1093/femsle/fnw059

Conference Contribution - Published proceedings: Abstract

Heng, N., Benn, C., Upritchard, J., Hale, J., Ross, J., Tompkins, G., Kieser, J., & Stanton, J.-A. (2016). Streptococcus kieseri sp. nov. from the New Zealand brushtail possum. Journal of Dental Research, 95(Spec Iss B), 1163. Retrieved from http://www.iadr.org/

Benic, G. Z., Farella, M., Biggs, P., Heng, N., Cannon, R., & Mei, L. (2016). Efficacy of oral probiotics in managing biofilm formation in patients wearing fixed orthodontic appliances: A triple-blind randomized placebocontrolled trial. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 18). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026

Heng, N. C. K., Benn, C., Hale, J. D. F., Ross, J. G., Tompkins, G. R., Kieser, J. A., & Stanton, J.-A. L. (2016). Streptococcus kieseri sp. nov. from the New Zealand brushtail possum. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 15). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N. C. K., Benn, C., Upritchard, J. E., Hale, J. D. F., Ross, J. G., Tompkins, G. R., Kieser, J. A., & Stanton, J.-A. L. (2016, November). Streptococcus kierseri sp. nov. from the New Zealand brushtail possum. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

2015

Conference Contribution - Published proceedings: Abstract

Heng, N. C., Wescombe, P. A., Stanton, J. L., & Tagg, J. (2015). Genome sequence of Streptococcus salivarius NCTC 8618 (ATCC 7073T). Journal of Dental Research, 94(Spec Iss B), 2343648. Retrieved from http://www.iadr.org/

Malik, A., Tagg, J. R., Stanton, J.-A. L., Sumayyah, S., Wescombe, P. A., & Heng, N. C. K. (2015). A tale of bacteriocin-encoding lactic acid bacterial genomes: Streptococcus salivarius NCTC 8618T and Weissella confusa MBF8-1. Proceedings of the New Zealand Microbiological Society (NZMS) 60th Conference. (pp. 37). Retrieved from http://www.nzmsconference.org.nz/

2014

Conference Contribution - Published proceedings: Abstract

Kamalendran, N., Yeh, C., Drummond, B., Heng, N., Cullinan, M. P., & Stanton, J. (2014). Oral microbiota of children undergoing comprehensive treatment for severe ECC. Journal of Dental Research, 93(Spec Iss C). Retrieved from http://www.iadr.org

Conference Contribution - Poster Presentation (not in published proceedings)

Yeh, C.-W., Kamalendran, N., Cullinan, M. P., Drummond, B. K., & Heng, N. (2014, May). Microbiological analysis of plaque samples from children with dental caries. Poster session presented at the International Association for Dental Research (IADR) New Zealand Section Student Poster Competition, Dunedin, New Zealand.

2013

Journal - Research Article

Cullinan, M. P., Bird, P. S., Heng, N. C. K., West, M. J., & Seymour, G. J. (2013). No evidence of triclosan-resistant bacteria following long-term use of triclosan-containing toothpaste. Journal of Periodontal Research, 49(2), 220-225. doi: 10.1111/jre.12098

2012

Journal - Research Article

Wescombe, P. A., Hale, J. D. F., Heng, N. C. K., & Tagg, J. R. (2012). Developing oral probiotics from Streptococcus salivarius. Future Microbiology, 7(12), 1355-1371. doi: 10.2217/fmb.12.113

Leishman, S. J., Ford, P. J., Do, H. L., Palmer, J. E., Heng, N. C. K., West, M. J., Seymour, G. J., & Cullinan, M. P. (2012). Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. Journal of Clinical Periodontology, 39(10), 923-930. doi: 10.1111/j.1600-051X.2012.01934.x

Conference Contribution - Published proceedings: Abstract

Benn, C., Kieser, J. A., Upritchard, J., Tompkins, G., Ross, J., & Heng, N. (2012). Identifying individual possums using their oral bacteria. Journal of Dental Research, 91(Spec Iss C), 169857. Retrieved from http://www.dentalresearch.org

Sundaresan, P. D., Murray, C. M., Wade, K. J., Cullinan, M. P., Drummond, B. K., Stanton, J. L., Seymour, G. J., & Heng, N. C. K. (2012). From babies to retirement: What microbes lurk in our mouths? Journal of Dental Research, 91(Spec Iss C), 169898. Retrieved from http://www.dentalresearch.org

Sundaresan, D., Cullinan, M., Drummond, B., Stanton, J., Seymour, G., & Heng, N. (2012). “Mummy, are there bugs in my mouth?”: Investigating the oral bacterial diversity of Dunedin children. New Zealand Medical Journal, 125(1355). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Sundaresan, D. P., Murray, C. M., Wade, K. J., Cullinan, M. P., Drummond, B. K., Stanton, J. L., Seymour, G. J., & Heng, N. C. K. (2012, September). From babies to retirement: What microbes lurk in our mouths? Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

2011

Journal - Research Article

Rose-Hill, S., Ford, P. J., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., … Seymour, G. J., & Cullinan, M. P. (2011). Improved periodontal health and cardiovascular risk. Australian Dental Journal, 56(4), 352-357. doi: 10.1111/j.1834-7819.2011.01363.x

Heng, N. C. K., Haji-Ishak, N. S., Kalyan, A., Wong, A. Y. C., Lovrić, M., Bridson, J. M., Artamonova, J., Stanton, J.-A. L., Wescombe, P. A., Burton, J. P., Cullinan, M. P., & Tagg, J. R. (2011). Genome sequence of the bacteriocin-producing oral probiotic Streptococcus salivarius strain M18. Journal of Bacteriology, 193(22), 6402-6403. doi: 10.1128/jb.06001-11

Frese, S. A., Benson, A. K., Tannock, G. W., Loach, D. M., Kim, J., Zhang, M., … Heng, N. C. K., … Walter, J. (2011). The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri. PLoS Genetics, 7(2), e1001314. doi: 10.1371/journal.pgen.1001314

Conference Contribution - Published proceedings: Abstract

Parachuru, P., Seymour, G., Rich, A., Milne, T., Coates, D., Cullinan, M., & Heng, N. (2011). Tregs and IL17 + cells infiltrate periodontal disease tissues. New Zealand Dental Journal. 107, (pp. 133). [Abstract]

Sundaresan, D., Cullinan, M., Drummond, B., Seymour, G., Stanton, J.-A., & Heng, N. (2011). Identification of friend and foe: Metagenomics of the oral cavity in health and disease. New Zealand Medical Journal. 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Praveen, P. V., Rich, A. M., Horne, L., Hussaini, H. M., Heng, N. C. K., Coates, D. E., Milne, T. J., & Seymour, G. J. (2011). Regulatory T-cells and Th17-cells infiltrate periodontal disease tissues. Journal of Dental Research, 90(Spec Iss A), 1429. Retrieved from http://www.dentalresearch.org

Conference Contribution - Poster Presentation (not in published proceedings)

Wolfer, M., Mashburn-Warren, L., Federle, M., Heng, N., & Morrison, D. (2011, September). Control of the competence regulon in pyogenic streptococci: Type II ComR receptors recognize species-specific peptide pheromones when expressed in a heterologous host. Poster session presented at the XVIII Lancefield International Symposium, Palermo, Italy.

Milne, T. J., Coates, D., Cullinan, M. P., Heng, N. C. K., Leichter, J. W., & Seymour, G. J. (2011, June). A multiplex qRT-PCR assay: A tool for determining periodontal treatment effectiveness. Poster session presented at the Institute of Molecular Genetics of Academy of Science of the Czech Republic Symposium: Developments in rReal-Time PCR from Preanalytics to Molecular Diagnostics, Prague, Czech Republic.

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N., Haji-Ishak, N., Kalyan, A., Wong, A., Lovric, M., Bridson, J., Artamonova, J., Stanton, J.-A., Wescombe, P., Burton, J., Cullinan, M., & Tagg, J. (2011, November). The genome sequence of the oral probiotic Streptococcus salivarius strain M18. Verbal presentation at the New Zealand Microbiological Society (NZMS) Conference: Right here, right now! Palmerston North, New Zealand.

Parachuru, P., Seymour, G., Rich, A., Milne, T., Coates, D., Cullinan, M., & Heng, N. (2011, August). Tregs and IL17⁺ cells infiltrate periodontal disease tissues. Verbal presentation at the Faculty of Dentistry 3M Research Day, Dunedin, New Zealand.

2010

Edited Book - Research

Seymour, G. J., Cullinan, M. P., & Heng, N. C. K. (Eds.). (2010). Oral Biology. New York: Springer, 360p.

Chapter in Book - Research

Heng, N. C. K., & Stanton, J.-A. L. (2010). Oral bacterial genome sequencing using the high-throughput Roche Genome Sequencer FLX System. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 197-218). New York: Springer. doi: 10.1007/978-1-60761-820-1_14

Journal - Research Article

Swe, P. M., Heng, N. C. K., Cook, G. M., Tagg, J. R., & Jack, R. W. (2010). Identification of Dysl, the immunity factor of the streptococcal bacteriocin dysgalacticin. Applied & Environmental Microbiology, 76(23), 7885-7889. doi: 10.1128/AEM.01707-10

Wescombe, P. A., Heng, N. C. K., Burton, J. P., & Tagg, J. R. (2010). Something old and something new: An update on the amazing repertoire of bacteriocins produced by Streptococcus salivarius. Probiotics & Antimicrobial Proteins, 2(1), 37-45. doi: 10.1007/s12602-009-9026-7

Conference Contribution - Published proceedings: Abstract

Ford, P. J., Rose-Hill, S., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., … Seymour, G. J., & Cullinan, M. P. (2010). Systematic response to improved periodontal health in a cardiovascular population. Journal of Dental Research, 89(Spec Iss B), 1818. Retrieved from http://www.dentalresearch.org

Ohlrich, E. J., Coates, D. E., Milne, T. J., Cullinan, M. P., Heng, N. C. K., Duncan, W. J., & Seymour, G. J. (2010). Biophosphonates alter angiogenesis gene expression in cultured human gingival fibroblasts. Journal of Dental Research, 89(Spec Iss B), 4930. Retrieved from http://www.dentalresearch.org

Rose-Hill, S., Ford, P. J., Leishman, S. J., Do, H. L., Palmer, J. E., Westerman, B., Heng, N. C. K., … Seymour, G., & Cullinan, M. (2010). Serum antibodies and inflammatory markers in improved periodontal health. Journal of Dental Research, 89(Spec Iss B), 3836. Retrieved from http://www.dentalresearch.org

Ohlrich, E., Coates, D., Milne, T., Cullinan, M., Heng, N., Duncan, W., & Seymour, G. (2010). Bisphosphonates alter angiogenesis gene expression in cultured human gingival fibroblasts. Proceedings of the Faculty of Dentistry 3M Research Day. Retrieved from http://dentistry.otago.ac.nz/research/index.html

2009

Journal - Research Article

Wescombe, P. A., Heng, N. C. K., Burton, J. P., Chilcott, C. N., & Tagg, J. R. (2009). Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiology, 4(7), 819-835. doi: 10.2217/fmb.09.61

Conference Contribution - Published proceedings: Abstract

Rose-Hill, S., Ford, P. J., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., … Seymour, G. J., & Cullinan, M. P. (2009). Improvement in periodontal health and antibody response to heat-shock proteins. Journal of Dental Research, 88(Spec Iss B), 388. Retrieved from http://www.dentalresearch.org

Wong, A. Y. C., Stanton, J.-A. L., Rand, C. J., Cullinan, M. P., Tagg, J. R., & Heng, N. C. K. (2009). Sequencing and annotating the genome of Streptococcus salivarius strain JH. Journal of Dental Research, 88(Spec Iss B), 258. Retrieved from http://www.dentalresearch.org

Haji-Ishak, N., Stanton, J.-A. L., Rand, C. J., Cullinan, M. P., Tagg, J. R., & Heng, N. C. K. (2009). Revealing the genomic secrets of Streptococcus salivarius strain Mia (M18). Journal of Dental Research, 88(Spec Iss B), 381. Retrieved from http://www.dentalresearch.org

Leishman, S. J., Ford, P. J., Rothnie, J., Bohnstedt, S., Cullinan, M. P., Westerman, B., … Heng, N., … Seymour, G. J. (2009). Antibody response to self and P.gingivalis heat-shock-proteins in cardiovascular patients. Journal of Dental Research, 88(Spec Iss A), 3024. Retrieved from http://www.dentalresearch.org

Haji-Ishak, N., Cullinan, M., Tagg, J., & Heng, N. (2009). Revealing the genomic secrets of the oral bacterium Streptococcus salivarius strain Mia. New Zealand Medical Journal, 122(1295). Retrieved from http://journal.nzma.org.nz/journal/122-1295/3623/content.pdf

Wong, A., Cullinan, M., Tagg, J., & Heng, N. (2009). Sequencing and annotating the genome of the oral bacterium Streptococcus salivarius JH. New Zealand Medical Journal, 122(1295). Retrieved from http://journal.nzma.org.nz/journal/122-1295/3623/content.pdf

2008

Conference Contribution - Published proceedings: Abstract

Heng, N. C., Cullinan, M. P., Drummond, B. K., Stanton, J. L., & Seymour, G. J. (2008). Metagenomics and more: The new genome sequencer FLX system and its applications. Proceedings of the Faculty of Dentistry 3M Research Day. Retrieved from http://dentistry.otago.ac.nz/research/rd2008/presentations.html

Hale, J. D. F., Heng, N. C. K., Power, D. A., Inglis, M. A., & Tagg, J. R. (2008). Sanguinicin K11, a novel antimicrobial peptide produced by the oral bacterium Steptococcus sanguinis. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 38). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Poster-Abstracts-NZMS-2008.pdf

Heng, N. C. K., Cullinan, M. P., Drummond, B. K., Stanton, J. L., Tagg, J. R., & Seymour, G. J. (2008). Hundreds and thousands: Sampling oral microbial diversity and whole-genome sequencing using the high-throughput Genome Sequencer FLX System. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 50). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Oral-Abstracts-NZMS-2008.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Nalder, T. D., Carne, A., Tannock, G. W., Heng, N. C., & Jack, R. W. (2008, November-December). Expression and characterisation of novel β-glucanases from non-culturable bacteria. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

2007

Chapter in Book - Research

Heng, N. C. K., Wescombe, P. A., Burton, J. P., Jack, R. W., & Tagg, J. R. (2007). The diversity of bacteriocins in gram-positive bacteria. In M. A. Riley & M. A. Chavan (Eds.), Bacteriocins: Ecology and evolution. (pp. 45-92). Berlin, Germany: Springer.

Journal - Research Article

Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2007). Competence-dependent bacteriocin production by Streptococcus gordonii DL1 (Challis). Journal of Bacteriology, 189(4), 1468-1472.

Heng, N. C. K., Burtenshaw, G. A., Jack, R. W., & Tagg, J. R. (2007). Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis. Applied & Environmental Microbiology, 73(23), 7763-7766.

Swe, P. M., Heng, N. C. K., Ting, Y.-T., Baird, H. J., Carne, A., Tauch, A., Tagg, J. R., & Jack, R. W. (2007). ef1097 and ypkK encode enterococcin V583 and corynicin JK, members of a new family of antimicrobial proteins (bacteriocins) with modular structure from Gram-positive bacteria. Microbiology, 153, 3218-3227.

Conference Contribution - Verbal presentation and other Conference outputs

Swe, P. M., Ting, Y.-T., Baird, H. J., Han, J., Carne, A., Tagg, J. R., Heng, N. C. K., & Jack, R. W. (2007, November). New scaffolds and novel targets for anti-infectives against pathogenic streptococci and vancomycin-resistant enterococci. Verbal presentation at the Joint New Zealand Microbiology Society and New Zealand Society for Biochemistry and Molecular Biology Annual Conference, Wellington, New Zealand.

Heng, N. C. K., Hale, J. D. F., Power, D. A., Inglis, M. A., & Tagg, J. R. (2007, November). Sanguinicin K11, a novel antimicrobial peptide produced by the oral bacterium Streptococcus sanguinis. Verbal presentation at the Joint New Zealand Microbiology Society and New Zealand Society for Biochemistry and Molecular Biology Annual Conference, Wellington, New Zealand.

Heng, N., Wirawan, R., Ritika, R., Power, D., Inglis, M., Jack, R., & Tagg, J. (2007, November). Molecular characterisation of natural nisin U (lantibiotic) variants produced by several streptococcal species. Verbal presentation at the Joint New Zealand Microbiology Society and New Zealand Society for Biochemistry and Molecular Biology Annual Conference, Wellington, New Zealand.

2006

Chapter in Book - Research

Heng, N. C. K., & Jack, R. W. (2006). Microcins. In A. J. Kastin (Ed.), Handbook of biologically active peptides. (pp. 75-82). Amsterdam: Elsevier.

Journal - Research Article

Wescombe, P. A., Burton, J. P., Cadieux, P. A., Klesse, N. A., Hyink, O., Heng, N. C. K., … Tagg, J. R. (2006). Megaplasmids encode differing combinations of lantibiotics in Streptococcus salivarius. Antonie van Leeuwenhoek, 90, 269-280.

Heng, N. C. K., & Tagg, J. R. (2006). What's in a name? Class distinction for bacteriocins [Correspondence]. Nature Reviews Microbiology, 4. Retrieved from http://www.nature.com/nrmicro/journal/v4/n2/full/nrmicro1273-c1.html

Eyles, R. F., Brooks, H. J. L., Townsend, C. R., Burtenshaw, G. A., Heng, N. C. K., Jack, R. W., & Weinstein, P. (2006). Comparison of Campylobacter jejuni PFGE and Penner subtypes in human infections and in water samples from the Taieri River catchment of New Zealand. Journal of Applied Microbiology, 101, 18-25.

Heng, N. C. K., Ragland, N. L., Swe, P. M., Baird, H. J., Inglis, M. A., Tagg, J. R., & Jack, R. W. (2006). Dysgalacticin: A novel, plasmid-encoded antimicrobial protein (bacteriocin) produced by Streptococcus dysgalactiae subsp. equisimilis. Microbiology, 152, 1991-2001.

Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2006). Identification and characterization of the loci encoding the competence-associated alternative σ factor of Streptococcus gordonii. FEMS Microbiology Letters, 259(1), 27-34.

Conference Contribution - Published proceedings: Full paper

Heng, N. C. K., Swe, P. M., Ting, Y.-T., Dufour, M., Baird, H. J., Ragland, N. L., Burtenshaw, G. A., Jack, R. W., & Tagg, J. R. (2006). The large antimicrobial proteins (bacteriocins) of streptococci. International Congress Series. 1289, (pp. 351-354). doi: 10.1016/j.ics.2005.11.020

Conference Contribution - Published proceedings: Abstract

Heng, N. C., McCaw, A. S., & Tagg, J. R. (2006). Comparative analysis of bacteriocin-encoding plasmids harbored by beta-hemolytic streptococci. Proceedings of the American Society for Microbiology Conference. (pp. 89-90). Washington, DC: ASM. [Abstract]

Heng, N. C., Swe, P. M., Ting, Y., Burtenshaw, G. A., Baird, H. J., Inglis, M. A., Ragland, N. L., Dufour, M., Simmonds, R. S., Jack, R. W., & Tagg, J. R. (2006). The class III (large) bacteriocins: An emerging group of intriguing antimicrobial proteins. Proceedings of the American Society for Microbiology Conference. (pp. 88-89). Washington, DC: ASM. [Abstract]

Heng, N. C., Wescombe, P. A., Burton, J. P., Hyink, O., Klesse, N. A., Cadieux, P. A., … Tagg, J. R. (2006). Blis islands: Megaplasmids as transmissible repositories of bacteriocin-encoding loci in Streptococcus salivarius. Proceedings of the American Society for Microbiology Conference. (pp. 90). Washington, DC: ASM. [Abstract]

Wirawan, R. E., Heng, N. C., Jack, R. W., & Tagg, J. R. (2006). The antimicrobial (bacteriocin) repertoire of Streptococcus uberis. Proceedings of the American Society for Microbiology Conference. (pp. 42). Washington, DC: ASM. [Abstract]

Heng, N. C., Tagg, J. R., & Tompkins, G. R. (2006). Competence-dependent bacteriocin/beta-hemolysin production in Streptococcus gordonii. Proceedings of the American Society for Microbiology Conference. (pp. 93-94). Washington, DC: ASM. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Baird, H. J., Ting, Y.-T., Swe, P. M., Heng, N. C. K., & Jack, R. W. (2006, November). Heterologous expression and characterisation of the putative 'domains' of the novel 17 kDa antimicrobial protein YpkK from Corynebacterium jeikeium. Poster session presented at the New Zealand Microbiological Society Conference, Hamilton, New Zealand.

McCaw, A. S., Heng, N. C. K., Tagg, J. R., & Jack, R. W. (2006, November). Heterologous expression and characterisation of the novel cell wall-degrading, antimicrobial protein stellalysin from Streptococcus constellatus. Poster session presented at the New Zealand Microbiological Society Conference, Hamilton, New Zealand.

Nalder, T. D., Heng, N. C. K., Tannock, G. W., Carne, A., & Jack, R. W. (2006, November). Heterologous expression and characterisation of novel β-glucanases from nonculturable gut bacteria identified via a metagenomic approach. Poster session presented at the New Zealand Microbiological Society Conference, Hamilton, New Zealand.

Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2006, November). Competence-dependent bacteriocin/β-haemolysin production by Streptococcus gordonii. Poster session presented at the New Zealand Microbiological Society Conference, Hamilton, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N. C. K., Wirawan, R. E., Swanson, K. M., & Tagg, J. R. (2006, November). Phenotypic and genotypic identification of bacteriocins produced by Streptococcus uberis. Verbal presentation at the New Zealand Microbiological Society Conference, Hamilton, New Zealand.

2005

Chapter in Book - Research

Wescombe, P. A., Heng, N. C. K., Jack, R. W., & Tagg, J. R. (2005). Bacteriocins associated with cytotoxicity for eukaryotic cells. In T. Proft (Ed.), Microbial toxins: Molecular and cellular biology. (pp. 399-448). Norfolk, England: Horizon Bioscience.

Journal - Research Article

Hale, J. D. F., Ting, Y.-T., Jack, R. W., Tagg, J. R., & Heng, N. C. K. (2005). Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: Elucidation of the antimicrobial repertoire by genetic dissection. Applied & Environmental Microbiology, 71(11), 7613-7617.

Rahimi, M., Heng, N. C. K., Kieser, J. A., & Tompkins, G. R. (2005). Genotypic comparison of bacteria recovered from human bite marks and teeth using arbitrarily primed PCR. Journal of Applied Microbiology, 99, 1265-1270.

Hale, J. D. F., Heng, N. C. K., Jack, R. W., & Tagg, J. R. (2005). Identification of nlmTE, the locus encoding the ABC transport system required for export of nonlantibiotic mutacins in Streptococcus mutans. Journal of Bacteriology, 187(14), 5036-5039.

Conference Contribution - Poster Presentation (not in published proceedings)

Heng, N. C. K., Hale, J. D. F., Ting, Y.-T., Jack, R. W., & Tagg, J. R. (2005, November). Production of bacteriocins (mutacins) by streptococcus mutans UA159: Elucidation of the antimicrobial repertoire and export mechanish. Poster session presented at the 50th Annual General Meeting of the New Zealand Microbiological Society, University of Otago, Dunedin.

Baird, H. J., Ting, Y.-T., Swe, P., Burtenshaw, G. A. A., Tagg, J. R., Heng, N. C. K., & Jack, R. W. (2005, November). Are the antimicrobial proteins SA-M57, EF1097, and YpkK composed of domains? Poster session presented at the 50th Annual General Meeting of the New Zealand Microbiological Society, University of Otago, Dunedin.

Hale, J., Heng, N., Ting, Y. T., Jack, R., & Tagg, J. (2005, September). Production of bacteriocins (mutacins) by streptococcus mutans UA159: Elucidation of the antimicrobial repertoire and export mechanish. Poster session presented at the 16th Lancefield International Symposium on Streptococci and Streptococcal Diseases, Palm Cove, Australia.

Swe, P., Heng, N. C. K., Cook, G. M., & Jack, R. W. (2005, November). Preliminary effects of the antimicrobial protein dysgalacticin against Streptococcus pyogenes. Poster session presented at the 50th Annual General Meeting of the New Zealand Microbiological Society, University of Otago, Dunedin.

Conference Contribution - Verbal presentation and other Conference outputs

Heng, N., Swe, P., Burtenshaw, G., Ting, Y. T., Ragland, N., Dufour, M., Tagg, J., & Jack, R. (2005, September). The large antimicrobial proteins (bacteriocins) of streptococci. Verbal presentation at the 16th Lancefield International Symposium on Streptococcal Diseases, Palm Cove, Australia.

Heng, N. C. K., Swe, P. M., Ting, Y.-T., Dufour, M., Ragland, N. L., Burtenshaw, G. A., Baird, H. J., Tagg, J. R., & Jack, R. W. (2005, November). The large antimicrobial proteins (bacteriocins) of streptococci. Verbal presentation at the 50th Annual General Meeting of the New Zealand Microbiological Society, University of Otago, Dunedin.

2004

Journal - Research Article

Heng, N. C. K., Burtenshaw, G. A., Jack, R. W., & Tagg, J. R. (2004). Sequence analysis of pDN571, a plasmid encoding novel bacteriocin production in M-type 57 Streptococcus pyogenes. Plasmid, 52, 225-229.

Conference Contribution - Published proceedings: Abstract

Tompkins, G. R., Heng, N. C. K., & Tagg, J. R. (2004). Competence-dependent bacteriocin production in Streptococcus gordonii DL1 (Challis). Proceedings of the 44th Annual Meeting of Australia and New Zealand Division: International Association of Dental Research. Fiji: IADR. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Swe, P. M., Heng, N. C. K., Tagg, J. R., & Jack, R. W. (2004, November). Cloning and expression of potential antimicrobial proteins from Enterococci and Corynebacteria. Poster session presented at the New Zealand Microbiological Society Conference: Microbes outside the square, Palmerston North, New Zealand.

Baird, H. J., Heng, N. C. K., Dufour, M., Tagg, J. R., & Jack, R. W. (2004, November). The antimicrobial protein dysgalacticin contains an essential disulphide bond. Poster session presented at the New Zealand Microbiological Society Conference: Microbes outside the square, Palmerston North, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Hale, J. D. F., Heng, N. C. K., & Tagg, J. R. (2004, November). Bacteriocin production in Streptococcus mutans strain UA159: Genetic dissection of the mutacin IV locus. Verbal presentation at the New Zealand Microbiological Society Conference: Microbes outside the square, Palmerston North, New Zealand.

Heng, N. C. K., Dufour, M., Ting, Y. T., Burtenshaw, G. A., Jack, R. W., & Tagg, J. R. (2004, November). Large antimicrobial proteins (bacteriocin) of Streptococci: Streptococcin A-M57 and Stellalysin A. Verbal presentation at the New Zealand Microbiological Society Conference: Microbes outside the square, Palmerston North, New Zealand.

2003

Journal - Research Article

Walter, J., Heng, N. C. K., Hammes, W. P., Loach, D. M., Tannock, G. W., & Hertel, C. (2003). Identification of Lactobacillus reuteri genes specifically induced in the mouse gastrointestinal tract. Applied & Environmental Microbiology, 69(4), 2044-2051.

2002

Conference Contribution - Published proceedings: Abstract

Rahimi, M. A., Heng, N. C. K., Kieser, J. A., & Tompkins, G. R. (2002). Forensic PCR analysis of bacteria recovered from bitemarks. Journal of Dental Research. 81(Special Issue A), (pp. A149). Alexandria, VA, USA: International Association for Dental Research. [Abstract]

Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2002). Establishment of a relationship between competence for genetic transformation and bacteriocin production in Streptococcus gordonci DLI (Challis). ASM COnferences Streptococcal Genetics (6th). (pp. 68-69). Washington, D.C.: American Society for Microbiology. [Abstract]

2001

Conference Contribution - Published proceedings: Abstract

Keng, F.-Y., Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2001). Competence-dependent bacteriocin sensitivity in Streptococcus gordonii. International Association for Dental Research Australia/New Zealand 41st Annual Scientific Meeting. [Abstract]

Keng, F.-Y., Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2001). Bacteriocins revisited: Competence and Bacteriocin Sensitivity in Streptococcus gordonii. New Zealand Microbiological Society Annual meeting. [Abstract]

Rahimi, M. A., Heng, N. C., Kieser, J. A., & Tompkins, G. R. (2001). ForensicPCR analysis of bacteria recovered from bite marks. International Association for Dental Research Australia/New Zealand 41st Annual Scientific Meeting. [Abstract]

Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2001). Licensed to Kill: Competence and Bacteriocin Production. Streptococcus gordonii. Wellington. [Abstract]

1999

Journal - Research Article

Heng, N. C. K., Bateup, J. M., Loach, D. M., Wu, X., Jenkinson, H. F., Morrison, M., & Tannock, G. W. (1999). Influence of different functional elements of plasmid pGT232 on maintenance of recombinant plasmids in Lactobacillus reuteri populations in vitro and in vivo. Applied & Environmental Microbiology, 65, 5378-5385.

1997

Journal - Research Article

Heng, N. C. K., Jenkinson, H. F., & Tannock, G. W. (1997). Cloning and expression of an endo-1,3-1,4-β-glucanase gene from Bacillus macerans in Lactobacillus reuteri. Applied & Environmental Microbiology, 63(8), 3336-3340.