Professor Julia Horsfield is a developmental geneticist based in the Department of Pathology at the University of Otago.
Julia leads a research group investigating the role of chromosome structure in animal development and cancer. Her specific research interest lies in cohesin proteins, which are present in all animals and important for cell division and DNA repair. As the name implies, cohesin proteins' main function is to hold replicated chromosomes together until cells divide. However, they are also involved in gene expression and this is where Julia's research focus lies, particularly in relation to Cornelia de Lange and Roberts syndromes.
Julia has worked with zebrafish as her model animal for the past 12 years. She moved from the University of Auckland to the University of Otago in 2007, introducing Otago researchers to zebrafish in the process. Her enthusiasm for the zebrafish animal model has attracted several senior researchers and their teams to zebrafish and this has ultimately led to the development of the new state-of-the-art facility.
Lynch, D. M., Meier, M., Labudina, A., Antony, J., & Horsfield, J. A. (2023). How STAG proteins influence cohesins role in cell fate determination. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Labudina, A. A., Gimenez, G., Meier, M., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2023). Using a zebrafish stem cell model to understand the molecular basis of cohesinopathies. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Labudina, A. A., Gimenez, G., Meier, M., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2023). Using a zebrafish stem cell model to understand the molecular basis of cohesinopathies. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Conference Contribution - Published proceedings: Abstract
Horsfield, J. (2023, March). The circle of life: Connecting cell division with cell fate. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
Other Research Output
Horsfield, J. A. (2023). Full circle: A brief history of cohesin and the regulation of gene expression. FEBS Journal, 290, 1670-1687. doi: 10.1111/febs.16362
Journal - Research Other
Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207. doi: 10.1096/fj.202101764R
Journal - Research Article
Schierding, W., Horsfield, J. A., & O'Sullivan, J. (2022). Genetic variation as a long-distance modulator of RAD21 expression in humans. Scientific Reports, 12(1), 13035. doi: 10.1038/s41598-022-15081-1
Journal - Research Article
Labudina, A. A., Gimenez, G., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2022). Using a zebrafish stem cell model to understand the molecular basis of Cornelia de Lange Syndrome. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Conference Contribution - Published proceedings: Abstract
Labudina, A. A., Gimenez, G., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2022). Using a zebrafish stem cell model to understand the molecular basis of Cornelia de Lange Syndrome. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Schenk, S., Horsfield, J., & Johnson, S. (2022). Zebrafish on "P": Behavioural effects of methamphetamine. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 95). Retrieved from https://www.queenstownresearchweek.org
Conference Contribution - Published proceedings: Abstract
Siemonek, A., Van Huffel, S., Gimenez, G., Weeks, R., Horsfield, J. A., Antony, J., & Dunbier, A. (2022). Unraveling the mechanisms involved in the co-regulation of breast cancer associated genes at the 6q25.1 locus. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Antony, J., Chin, C. V., & Horsfield, J. A. (2021). Cohesin mutations in cancer: Emerging therapeutic targets. International Journal of Molecular Sciences, 22(13), 6788. doi: 10.3390/ijms22136788
Journal - Research Article
Leask, M., Carleton, C., Leeke, B., Newman, T., Antoun, J., Farella, M., & Horsfield, J. (2021). Riboceine rescues auranofin-induced craniofacial defects in zebrafish. Antioxidants, 10, 1964. doi: 10.3390/antiox10121964
Journal - Research Article
Schierding, W., Horsfield, J. A., & O'Sullivan, J. M. (2021). Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways. Journal of Medical Genetics, 58, 534-542. doi: 10.1136/jmedgenet-2020-107095
Journal - Research Article
Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175
Journal - Research Article
Labudina, A., & Horsfield, J. A. (2021). The three-dimensional genome in zebrafish development. Briefings in Functional Genomics, 20(6), 370-377. doi: 10.1093/bfgp/elab008
Journal - Research Other
Horsfield, J. (2021). The circle of life: Connecting cell division with cell fate [Keynote]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Horsfield, J. (2021). Why signalling pathways are altered by cohesin deficiency [Jisnuson Svasit Lecture]. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 43). Retrieved from https://www.faobmb2021.org
Conference Contribution - Published proceedings: Abstract
Labudina, A., Antony, J., Meier, M., & Horsfield, J. (2021). Cohesin and pioneer factors act independently in zygotic genome activation in zebrafish. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 58). Retrieved from https://www.faobmb2021.org
Conference Contribution - Published proceedings: Abstract
Morice, M., Bixley, M., Cadzow, M., Major, T., Phipps-Green, A., Topless, R., Merriman, M., Merriman, T. R., Leask, M., & Horsfield, J. (2021). Replication of a Māori and Pacific-specific T2D-risk variant within JAZF1. New Zealand Medical Journal, 134(1547), (pp. 142). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Siemonek, A., Van Huffel, S., Gimenez, G., Horsfield, J. A., Antony, J., & Dunbier, A. (2021). Unraveling the mechanisms involved in the co-regulation of breast cancer associated genes at the 6q25.1 locus. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Boocock, J., Leask, M., Okada, Y., Asian Genetic Epidemiology Network (AGEN) Consortium, Matsuo, H., Shi, Y., … Cadzow, M., Gosling, A. L., Major, T. J., Horsfield, J. A., … Merriman, T. R. (2020). Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Human Molecular Genetics, 29(6), 923-943. doi: 10.1093/hmg/ddaa013
Journal - Research Article
Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405
Journal - Research Article
Chiu, J. Z. S., Hold, I., Newman, T. A. C., Horsfield, J. A., & McDowell, A. (2020). Chlorogenic acid supplementation benefits zebrafish embryos exposed to auranofin. Pharmaceutics, 12, 1199. doi: 10.3390/pharmaceutics12121199
Journal - Research Article
Ketharnathan, S., Labudina, A., & Horsfield, J. A. (2020). Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos. Frontiers in Cell & Developmental Biology, 8, 617545. doi: 10.3389/fcell.2020.617545
Journal - Research Article
Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256
Journal - Research Article
Antony, J., Gimenez, G., Taylor, T., Khatoon, U., Day, R., Morison, I. M., & Horsfield, J. A. (2020). BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells. Journal of Molecular Cell Biology, 12(5), 397-399. doi: 10.1093/jmcb/mjz114
Journal - Research Other
Kamstra, K., Horsfield, J. A., & Tups, A. (2020). The effects of leptin mutations and diet-induced obesity on glucose homeostasis in the zebrafish. New Zealand Medical Journal, 133(1527), (pp. 129). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. New Zealand Medical Journal, 133(1518), (pp. 98). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2
Journal - Research Article
Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733
Journal - Research Article
Horsfield, J. A. (2019). Packaging development: How chromatin controls transcription in zebrafish embryogenesis. Biochemical Society Transactions, 47(2), 713-724. doi: 10.1042/bst20180617
Journal - Research Other
Kline, A. D., Krantz, I. D., Bando, M., Shirahige, K., Chea, S., Sakata, T., … Horsfield, J. A., … Haaland, R. E. (2019). Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th Biennial Scientific and Educational Symposium 2018 [Conference report]. American Journal of Medical Genetics Part A, 179(6), 1080-1090. doi: 10.1002/ajmg.a.61108
Journal - Professional & Other Non-Research Articles
Meier, M., Grant, J., Dowdle, A. E., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2019). A zebrafish model for cohesin function in early embryo development. American Journal of Medical Genetics Part A, 179(6), (pp. 1083-1084). doi: 10.1002/ajmg.a.61108
Conference Contribution - Published proceedings: Abstract
Cukrov, D., Newman, T., Leask, M., Leeke, B., Sarogni, P., Patimo, A., … Horsfield, J., & Musio, A. (2018). Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human Molecular Genetics, 27(17), 3002-3011. doi: 10.1093/hmg/ddy203
Journal - Research Article
Kaur, G., Li, C. G., Chantry, A., Stayner, C., Horsfield, J., & Eccles, M. R. (2018). SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma. Oncotarget, 9(42), 26852-26867. doi: 10.18632/oncotarget.25516
Journal - Research Article
Ketharnathan, S., Leask, M., Boocock, J., Phipps-Green, A. J., Antony, J., O'Sullivan, J. M., Merriman, T. R., & Horsfield, J. A. (2018). A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human Molecular Genetics, 27(22), 3964-3973. doi: 10.1093/hmg/ddy295
Journal - Research Article
Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., & Gemmell, N. J. (2018). Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of Reproduction, 99(2), 446-460. doi: 10.1093/biolre/iox175
Journal - Research Article
Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635
Journal - Research Article
Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2018). Cohesin facilitates zygotic genome activation in zebrafish. Development, 145, dev156521. doi: 10.1242/dev.156521
Journal - Research Article
Schierding, W., Antony, J., Karhunen, V., Vääräsmäki, M., Franks, S., Elliott, P., … Horsfield, J. A., … Cutfield, W. S. (2018). GWAS on prolonged gestation (post-term birth): Analysis of successive Finnish birth cohorts. Journal of Medical Genetics, 55(1), 55-63. doi: 10.1136/jmedgenet-2017-104880
Journal - Research Article
Antony, J., Giminez, G., Khatoon, U., Day, R., Morison, I., & Horsfield, J. (2018). Targeted disruption of the cohesin subunit STAG2 leads to loss of insulation and inappropriate gene activation in response to differentiation signals. Blood, 132(Suppl. 1), (pp. 878). doi: 10.1182/blood-2018-99-117965
Conference Contribution - Published proceedings: Abstract
Carleton, C., Antoun, J., Low, A., Horsfield, J., & Farella, M. (2018). A novel model for exploring causes and treatment of craniofacial birth defects. European Journal of Orthodontics, 40(5), (pp. e51). doi: 10.1093/ejo/cjy060
Conference Contribution - Published proceedings: Abstract
Leask, M., Merriman, T. R., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Horsfield, J. (2018). Non-coding urate-associated variants function in a conserved lincrna regulatory domain that alters MAF transcription. Arthritis & Rheumatology, 70(9, Suppl.), 2238. doi: 10.1002/art.40700
Conference Contribution - Published proceedings: Abstract
Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Fisher, A., & Gemmell, N. J. (2017). Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics, 18, 557. doi: 10.1186/s12864-017-3915-z
Journal - Research Article
Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2017). A DNA contact map for the mouse Runx1 gene identifies novel haematopoietic enhancers. Scientific Reports, 7, 13347. doi: 10.1038/s41598-017-13748-8
Journal - Research Article
McKinlay, P., Keller, C., & Horsfield, J. (2017). It’s written in your DNA: Or is it? Junctures, 2017(18), 81-87.
Journal - Research Article
McKinlay, P., Pickery, J.-J., & Horsfield, J. (2017). The GENE-ration game. Junctures, 2017(18), 71-80.
Journal - Research Article
Stayner, C., Poole, C. A., McGlashan, S. R., Pilanthananond, M., Brauning, R., Markie, D., … Slobbe, L., … Parker, K., Wiles, A., … Leichter, A., Leask, M., … Jennings, M., Horsfield, J. A., Walker, R. J., & Eccles, M. R. (2017). An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports, 7, 1601. doi: 10.1038/s41598-017-01519-4
Journal - Research Article
Chin, A., Antony, J., & Horsfield, J. (2017). Identifying synthetic lethal drugs for cohesin mutant AML. Proceedings of the 38th Annual Lorne Genome Conference. Retrieved from http://genome-2017.m.asnevents.com.au/
Conference Contribution - Published proceedings: Abstract
Cucco, F., Kline, A. D., Krantz, I. D., Horsfield, J., & Musio, A. (2017). Effects of anti-oxidant treatment on genome stability and in vitro growth of Cornelia de Lange syndrome cell lines. American Journal of Medical Genetics Part A, 173A(5), (pp. 1183-1184). doi: 10.1002/ajmg.a.38161
Conference Contribution - Published proceedings: Abstract
Dowdle, A., Gerton, J., O'Sullivan, J., & Horsfield, J. (2017). Coming of age: The role of nuclear structure in zygotic genome activation. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 540. Retrieved from http://gen2017.w.events4you.currinda.com
Conference Contribution - Published proceedings: Abstract
Ketharnathan, S., Leask, M., Merriman, T., & Horsfield, J. (2017). Functional analysis of a gout-associated noncoding snp variant. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 706. Retrieved from http://gen2017.w.events4you.currinda.com
Conference Contribution - Published proceedings: Abstract
Marsman, J., Thomas, A., Osato, M., O'Sullivan, J., & Horsfield, J. A. (2017). Identifying functional roles for novel cis-regulatory elements predicted to regulate the Runx1 gene. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 789. Retrieved from http://gen2017.w.events4you.currinda.com
Conference Contribution - Published proceedings: Abstract
Merriman, T. R., Ketharnathan, S., Boocock, J., Phipps-Green, A., Antony, J., Leask, M., … Horsfield, J. (2017). A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Arthritis & Rheumatology, 69(Suppl. 10), 2897. doi: 10.1002/art.40321
Conference Contribution - Published proceedings: Abstract
Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., & Horsfield, J. A. (2017). Neural crest origin for cohesinopathy heart defects. American Journal of Medical Genetics Part A, 173(5), (pp. 1178). doi: 10.1002/ajmg.a.38161
Conference Contribution - Published proceedings: Abstract
Chatterjee, A., Lagisz, M., Rodger, E. J., Zhen, L., Stockwell, P. A., Duncan, E. J., Horsfield, J. A., … Nakagawa, S. (2016). Sex differences in DNA methylation and expression in zebrafish brain: A test of an extended ‘male sex drive’ hypothesis. Gene, 590, 307-316. doi: 10.1016/j.gene.2016.05.042
Journal - Research Article
Dasgupta, T., Antony, J., Braithwaite, A. W., & Horsfield, J. A. (2016). HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting cohesin-dependent transcription in MCF7 cancer cells. Journal of Biological Chemistry, 291(24), 12761-12770. doi: 10.1074/jbc.M115.704627
Journal - Research Article
Newman, T., Jhinku, N., Meier, M., & Horsfield, J. (2016). Dietary intake influences adult fertility and offspring fitness in zebrafish. PLoS ONE, 11(11), e01663394. doi: 10.1371/journal.pone.0166394
Journal - Research Article
Schierding, W., Antony, J., Cutfield, W. S., Horsfield, J. A., & O'Sullivan, J. M. (2016). Intergenic GWAS SNPs are key components of the spatial and regulatory network for human growth. Human Molecular Genetics, 25(15), 3372-3382. doi: 10.1093/hmg/ddw165
Journal - Research Article
Carleton, C., Leeke, B., Leask, M., Farella, M., Antoun, J., & Horsfield, J. (2016). A novel model for exploring the causes and treatments of craniofacial birth defects. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
Conference Contribution - Published proceedings: Abstract
Hold, I., Chiu, J. Z. S., Newman, T. A. C., Horsfield, J. A., & McDowell, A. (2016). A zebrafish model demonstrates that chlorogenic acid rescues developmental abnormalities induced by oxidative stress. Proceedings of the Drug Delivery Australia Conference. (pp. 50). Retrieved from http://www.crsaustralia.org/
Conference Contribution - Published proceedings: Abstract
Marsman, J., Thomas, A. L., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2016). A Runx1 interactome identifies novel hematopoietic enhancers. Blood, 128(22), 726. Retrieved from http://www.bloodjournal.org
Conference Contribution - Published proceedings: Abstract
Newman, T., Leeke, B., Carleton, C., Leask, M., Hampton, M., & Horsfield, J. (2016). How zebrafish can help understand craniofacial biology. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 16-17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
Conference Contribution - Published proceedings: Abstract
van Huffel, S., Day, R. C., Antony, J., Marsman, J., Horsfield, J. A., & Dunbier, A. K. (2016). 4CSeq analysis of a breast cancer susceptibility locus on 6q25.1. Cancer Research, 76(14, Suppl.), 4518. doi: 10.1158/1538-7445.AM2016-4518
Conference Contribution - Published proceedings: Abstract
Antony, J., Dasgupta, T., Rhodes, J. M., McEwan, M. V., Print, C. G., O'Sullivan, J. M., & Horsfield, J. A. (2015). Cohesin modulates transcription of estrogen-responsive genes. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1849(3), 257-269. doi: 10.1016/j.bbagrm.2014.12.011
Journal - Research Article
Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology, 6, 648-655. doi: 10.1016/j.redox.2015.10.010
Journal - Research Article
Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., & Horsfield, J. A. (2015). A neural crest origin for cohesinopathy heart defects. Human Molecular Genetics, 24(24), 7005-7016. doi: 10.1093/hmg/ddv402
Journal - Research Article
Carleton, C., Antoun, J., Farella, M., Leeke, B., & Horsfield, J. (2015). A novel model for exploring craniofacial birth defects. Journal of Dental Research, 94(Spec Iss B), 2343906. Retrieved from http://www.iadr.org/
Conference Contribution - Published proceedings: Abstract
Hold, I., Chiu, J. Z. S., Newman, T., Horsfield, J. A., & McDowell, A. (2015). The antioxidant activity of chlorogenic acid isolated from puha, a New Zealand native plant, in a zebrafish model. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070
Conference Contribution - Published proceedings: Abstract
Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: Underlying mechanisms. Experimental Hematology & Oncology, 3, 13. doi: 10.1186/2162-3619-3-13
Journal - Research Article
Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M., & Horsfield, J. A. (2014). Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1839(1), 50-61. doi: 10.1016/j.bbagrm.2013.11.007
Journal - Research Article
O'Sullivan, J. M., Doynova, M. D., Antony, J., Pichlmuller, F., & Horsfield, J. A. (2014). Insights from space: Potential role of diet in the spatial organization of chromosomes. Nutrients, 6(12), 5724-5739. doi: 10.3390/nu6125724
Journal - Research Article
Chatterjee, A., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2014). Base-resolution DNA methylation landscape of zebrafish brain and liver [Data in brief]. Genomics Data, 2, 342-344. doi: 10.1016/j.gdata.2014.10.008
Journal - Research Other
Kline, A. D., Calof, A. L., Schaaf, C. A., Krantz, I. D., Jyonouchi, S., Yokomori, K., … Horsfield, J., … Dorsett, D. (2014). Cornelia de Lange syndrome: Further delineation of phenotype, cohesin biology and educational focus, 5th Biennial Scientific and Educational Symposium abstracts [Conference report]. American Journal of Medical Genetics Part A, 164(6), 1384-1393. doi: 10.1002/ajmg.a.36417
Journal - Professional & Other Non-Research Articles
White, J., van Huffel, S., Antony, J., Horsfield, J. A., & Dunbier, A. K. (2014). Expression of genes spanning a breast cancer susceptibility locus on 6q25.1 is modulated by epigenetic modification. Cancer Research, 74(19, Suppl.), 403. doi: 10.1158/1538-7445.AM2014-403
Conference Contribution - Published proceedings: Abstract
Chatterjee, A., Ozaki, Y., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2013). Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-989. doi: 10.4161/epi.25797
Journal - Research Article
Deardorff, M. A., Wilde, J. J., Albrecht, M., Dickinson, E., Tennstedt, S., Braunholz, D., Mönnich, M., … Horsfield, J. A., & Kaiser, F. J. (2012). RAD21 mutations cause a human cohesinopathy. American Journal of Human Genetics, 90(6), 1014-1027. doi: 10.1016/j.ajhg.2012.04.019
Journal - Research Article
Horsfield, J. A., Print, C. G., & Mönnich, M. (2012). Diverse developmental disorders from The One Ring: Distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics, 3, 171. doi: 10.3389/fgene.2012.00171
Journal - Research Article
Marsman, J., & Horsfield, J. A. (2012). Long distance relationships: Enhancer-promoter communication and dynamic gene transcription. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1819(11-12), 1217-1227. doi: 10.1016/j.bbagrm.2012.10.008
Journal - Research Article
McEwan, M. V., Eccles, M. R., & Horsfield, J. A. (2012). Cohesin is required for activation of MYC by estradiol. PLoS ONE, 7(11), e49160. doi: 10.1371/journal.pone.0049160
Journal - Research Article
Newman, T., Hampton, M., & Horsfield, J. (2012). A developmental role for Peroxiredoxin 3. Proceedings of the Oxygen Theme Meeting. (pp. 15). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Conference Contribution - Published proceedings: Abstract
Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. (2011). A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE, 6(5), e20051. doi: 10.1371/journal.pone.0020051
Journal - Research Article
Rhodes, J. M., McEwan, M., & Horsfield, J. A. (2011). Gene regulation by cohesin in cancer: Is the ring an unexpected party to proliferation? Molecular Cancer Research, 9(12), 1587-1607. doi: 10.1158/1541-7786.mcr-11-0382
Journal - Research Article
Kaiser, F. J., Braunholz, D., Wilde, J., Albrecht, M., Clark, D., Rampuria, A., … Horsfield, J. A., & Deardorff, M. A. (2011). Mutations in RAD21 as a cause of a new cohesinopathy. Proceedings of the German Society of Human Genetics Jahrestagung [Annual Convention]. (pp. 46). GfH. Retrieved from http://www.gfhev.de/de/kongress/2011_Abstractband.pdf
Conference Contribution - Published proceedings: Abstract
Kaiser, F. J., Braunholz, D., Wilde, J., Gil-Rodriguez, C., Albrecht, M., Clark, D., … Horsfield, J. A., & Deardorff, M. A. (2011). Mutations in RAD21 as a cause of a new cohesinopathy. European Journal of Human Genetics, 19(Suppl. 2), (pp. 28). [Abstract]
Conference Contribution - Published proceedings: Abstract
Rhodes, J. M., Bentley, F. K., Print, C. G., Dorsett, D., Misulovin, Z., Dickinson, E. J., … Horsfield, J. A. (2010). Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology, 344, 637-649. doi: 10.1016/j.ydbio.2010.05.493
Journal - Research Article
Horsfield, J. (2010). Using zebrafish to understand cancer: Regulation of c-Myc by cohesin. Proceedings of the Centre for Reproduction and Genomics Second Annual Research Colloquium. (pp. 13). Retrieved from http://www.crg.org.nz/colloquium/colloquium.aspx
Conference Contribution - Published proceedings: Abstract
Mönnich, M., Dickinson, E., Doidge, Z., Print, C., Eccles, M., Robertson, S., & Horsfield, J. (2010). Modelling human "Cohesinopathies" in zebrafish. American Journal of Medical Genetics Part A, (7), 152A, (pp. 1637). doi: 10.1002/ajmg.a.33439
Conference Contribution - Published proceedings: Abstract
Rhodes, J., Bentley, F., & Horsfield, J. (2010). Direct regulation of c-Myc by cohesin. New Zealand Medical Journal, 123(1321). Retrieved from http://journal.nzma.org.nz/journal/123-1321/4329/content.pdf
Conference Contribution - Published proceedings: Abstract
Mönnich, M., Banks, S., Eccles, M., Dickinson, E., & Horsfield, J. (2009). Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expression Patterns, 9(8), 586-594. doi: 10.1016/j.gep.2009.08.004
Journal - Research Article
Horsfield, J. A., Anagnostou, S. H., Hu, J. K.-H., Cho, K. H. Y., Geisler, R., Lieschke, G., … Crosier, P. S. (2009). Cohesin-dependent regulation of gene expression in zebrafish. American Journal of Medical Genetics Part A, 149A(8), (pp. 1621-1622). doi: 10.1002/ajmg.a.32911
Conference Contribution - Published proceedings: Abstract
Horsfield, J. A., Anagnostou, S. H., Hu, J. K.-H., Cho, K. H. Y., Geisler, R., Lieschke, G., … Crosier, P. S. (2007). Cohesin-dependent regulation of Runx genes. Development, 134, 2639-2649. doi: 10.1242/dev.002485
Journal - Research Article
Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., … Richardson, H. (2004). A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in drosophilia. Genetics, 168(1), 227-251. doi: 10.1534/genetics.104.026617
Journal - Research Article
Kalev-Zylinska, M. L., Horsfield, J. A., Flores, M. V., Postlethwait, J. H., Chau, J. Y., Cattin, P. M., … Crosier, K. E. (2003). Runx3 is required for hematopoietic development in zebrafish. Developmental Dynamics, 228(3), 323-336. doi: 10.1002/dvdy.10388
Journal - Research Article
Brumby, A. M., Zraly, C. B., Horsfield, J. A., Secombe, J., Saint, R., Dingwall, A. K., & Richardson, H. (2002). Drosophila cyclin E interacts with components of the Brahma complex. EMBO Journal, 21(13), 3377-3389. doi: 10.1093/emboj/cdf334
Journal - Research Article
Crosier, P. S., Kalev-Zylinska, M. L., Hall, C. J., Flores, M. V. C., Horsfield, J. A., & Crosier, K. E. (2002). Pathways in blood and vessel development revealed through zebrafish genetics. International Journal of Developmental Biology, 46, 493-502.
Journal - Research Article
Horsfield, J., Ramachandran, A., Reuter, K., Lavallie, E., Collins-Racie, L., Crosier, K., & Crosier, P. (2002). Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mechanisms of Development, 115, 15-26. doi: 10.1016/S0925-4773(02)00094-1
Journal - Research Article
Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.
Journal - Research Article
Tate, W. P., Poole, E. S., Horsfield, J. A., Mannering, S. A., Brown, C. M., Moffat, J. G., Dalphin, M. E., … Major, L. L., & Wilson, D. N. (1995). Translational termination efficiency in both bacteria and mammals is regulated by the base following the stop codon. Biochemistry & Cell Biology, 73, 1095-1103. doi: 10.1139/o95-118
Journal - Research Article
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