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Tony Kettle and Kate Vick in the labThe Department of Pathology has a number of potential topics and projects on offer in the fields of biomedical science and pathology for a range of postgraduate qualifications, including PhD and BBiomedSc(Hons).

Scholarship funding for postgraduate study may be available to you depending on your academic merit.

We welcome enquiries and encourage all prospective students to directly contact potential supervisors in their field of interest.

Free Radical Research

Potential TopicsContacts
  • Radical reactions with superoxide.
  • The role of free radicals and chlorine bleach in inflammatory diseases
  • Bacterial killing by neutrophils
  • The enzymology of peroxidases
  • Identification of biomarkers of hypochlorous acid

Professor Tony Kettle

  • Infammatory oxidants and cell and tissue injury
  • Effects of white cell-derived oxidants on cell signaling responses
  • Regulation of transciption factors and gene expression by oxidant stress
  • The regulation of neutrophils apoptosis and resolution of inflammation
  • The role of vitamin C in the regulation of the hypoxic response - Effect on cancer cell survival
  • The hypoxic response and neutrophil apoptosis
  • Hypoxia inducible factor-1 and cancer survival after chemotherapy

Professor Margreet Vissers

  • Redox regulation of cell signalling
  • Cell death pathways in cancer and immune cells
  • Mitochondrial dysfunction in ageing and disease
  • Understanding mitochondrial antioxidant systems and targeting these pathways in cancer cells
  • Anti-cancer and anti-inflammatory properties of isothiocyanates

Professor Mark Hampton

Gene Structure and Function Laboratory

Potential TopicsContact
  • Pharmacogenomics and genomics
  • Genetics of complex traits
  • Role of G-quadruplex DNA structures in biological processes

Professor Martin Kennedy

Inflammation Research Group

Potential TopicsContact
  • Gas mediators in inflammation
  • Neurogenic inflammation in acute pancreatitis, sepsis, and burns
  • Chemokines in acute pancreatitis, sepsis, and burns
  • Apoptosis of pancreatic acinar cells

Professor Madhav Bhatia

Coagulation and Vascular Disease

Background: molecular, biochemisry, genetics.

Contact: Professor Peter George

Infectious Diseases, Microbiology

Potential TopicsContacts
  • Pneumonia and other respiratory infection
  • Legionnaires' disease
  • Vitamin D and infection
  • Staphylococcus aureus disease

Mackenzie Cancer Research Group

Potential TopicsContacts
  • Vitamin C in cancer
  • Hypoxia, HIF-1 and tumour progression
  • Obesity, chemotherapy and breast cancer
  • Exercise and breast cancer
  • Inflammation and cancer
  • Genetic variation and cancer development
  • Gene expression and tumour development

Background: cancer, cell biology, molecular biology, chemotherapy, genomics, genetics

Molecular Pathology

Potential TopicsContact
  • Genetic and acquired abnormalities of blood proteins
  • Protein structure, function and disease
  • The contribution of post translational changes to disease
  • Fibrinogen variation and disease; bleeding, thrombosis, hepatitis and renal failure
  • Protein imprinting; novel protein biomarkers of disease; Serum albumin and Apo Al as time resolved markers of pancreatitis

Professor Steve Brennan

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