Associate Professor Haizal Hussaini
| Position | Associate Professor |
|---|---|
| Department | Department of Oral Diagnostic and Surgical Sciences |
| Qualifications | BDS MDentSci(Leeds) PhD(Otago) FDSRCSEd |
| Research summary | Oral pathology and immunology |
| Teaching | Undergraduate:
Postgraduate:
|
Research
My main core research interest is investigating immune responses in the tumour microenvironment, particularly oral squamous cell carcinoma. This research started in 2007 with subsequent completion of my PhD thesis in 2013. Three grants were obtained to fund this project with me as Principle Investigator one from Otago Medical Research Foundation (OMRF) and two from New Zealand Dental Association Research Foundation (NZDRF). This project is currently being expanded to include metastatic lymph node profiling as well as angiogenic role in oral squamous cell carcinoma metastatic spread. The current research will explore modulation of the immune system by cancer cells in the process of local invasion and lymph node metastasis and the role of angiogenesis in these processes.
Publications
Edirisinghe, S. T., Devmini, T., Pathmaperuma, S., Weerasekera, M., de Silva, K., Liyanage, I., … Rich, A., De Silva, H., Hussaini, H., … Yasawardene, S. (2023). Risk assessment of alcohol consumption for oral cancer: A case-control study in patients attending the National Cancer Institute (Apeksha Hospital, Maharagama) of Sri Lanka. Asian Pacific Journal of Cancer Prevention, 24, 1181-1185. doi: 10.31557/apjcp.2023.24.4.1181
Rich, A. M., Hussaini, H. M., Mohd Nizar, M. A., Gavidi, R. O., Tauati-Williams, E., Yakin, M., & Seo, B. (2023). Diagnosis of oral potentially malignant disorders: Overview and experience in Oceania. Frontiers in Oral Health, 4, 1122497. doi: 10.3389/froh.2023.1122497
Edirisinghe, S. T., Weerasekera, M., De Silva, D. K., Devmini, M. T., Pathmaperuma, S., Wijesinghe, G. K., … Hussaini, H., Rich, A. M., De Silva, H., Milne, T., … Yasawardene, S. (2023). Vascular Endothelial Growth Factor A (VEGF-A) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) as potential biomarkers for oral squamous cell carcinoma: A Sri Lankan study. Asian Pacific Journal of Cancer Prevention, 24(1), 267-274. doi: 10.31557/apjcp.2023.24.1.267
Hussaini, H. M., Seo, B., & Rich, A. M. (2023). Immunohistochemistry and immunofluorescence. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 439-450). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_26
Arora, S., Seo, B., Friedlander, L., & Hussaini, H. M. (2023). A cell culture method for the isolation and study of primary human dental pulp cells. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 393-405). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_22
Arora, S., Seo, B., Friedlander, L., & Hussaini, H. M. (2023). A cell culture method for the isolation and study of primary human dental pulp cells. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 393-405). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_22
Chapter in Book - Research
Hussaini, H. M., Seo, B., & Rich, A. M. (2023). Immunohistochemistry and immunofluorescence. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 439-450). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_26
Chapter in Book - Research
Edirisinghe, S. T., Devmini, T., Pathmaperuma, S., Weerasekera, M., de Silva, K., Liyanage, I., … Rich, A., De Silva, H., Hussaini, H., … Yasawardene, S. (2023). Risk assessment of alcohol consumption for oral cancer: A case-control study in patients attending the National Cancer Institute (Apeksha Hospital, Maharagama) of Sri Lanka. Asian Pacific Journal of Cancer Prevention, 24, 1181-1185. doi: 10.31557/apjcp.2023.24.4.1181
Journal - Research Article
Edirisinghe, S. T., Weerasekera, M., De Silva, D. K., Devmini, M. T., Pathmaperuma, S., Wijesinghe, G. K., … Hussaini, H., Rich, A. M., De Silva, H., Milne, T., … Yasawardene, S. (2023). Vascular Endothelial Growth Factor A (VEGF-A) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) as potential biomarkers for oral squamous cell carcinoma: A Sri Lankan study. Asian Pacific Journal of Cancer Prevention, 24(1), 267-274. doi: 10.31557/apjcp.2023.24.1.267
Journal - Research Article
AlSamahi, S., Milne, T. M., Hussaini, H., Rich, A. M., & Friedlander, L. T. (2022). Type 2 diabetes and the clinically normal pulp: An in-vitro study. International Endodontic Journal. Advance online publication. doi: 10.1111/iej.13732
Journal - Research Article
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Journal - Research Article
Aziz, M. A., Seo, B., Hussaini, H. M., Hibma, M., & Rich, A. M. (2022). Comparing two methods for the isolation of exosomes. Journal of Nucleic Acids, 8648373. doi: 10.1155/2022/8648373
Journal - Research Article
Edirisinghe, S. T., Weerasekera, M., De Silva, D. K., Liyanage, I., Niluka, M., Madushika, K., … Rich, A. M., De Silva, H., Hussaini, H. M., … Yasawardene, S. (2022). The risk of oral cancer among different categorise tobacco smoking exposure in Sri Lanka. Asian Pacific Journal of Cancer Prevention, 23, 2929-2935. doi: 10.31557/apjcp.2022.23.9.2929
Journal - Research Article
Oude-Alink, C., Hussaini, H. M., Seo, B., & Firth, F. (2022). Regulatory compliance of online vendor selling dental whitening products in New Zealand. Journal of the Royal Society of New Zealand. Advance online publication.
Journal - Research Article
Sood, Z. M., Nik-Azis, N. M., Baharin, B., Zainuddin, Z. M., Razali, M., & Hussaini, H. M. (2022). An insight into the role of periodontitis as a potential risk factor for development of erectile dysfunction. Archives of Orofacial Sciences, 17(Suppl. 1), 107-118. doi: 10.21315/aos2022.17S1.OA08
Journal - Research Article
Tay, W. Z., Dong, F., Kalmadin, N. I., Hussaini, H. M., De Silva, H. L., & Rich, A. M. (2022). PD-L1 expression in non-dysplastic, dysplastic and oral squamous cell carcinoma samples. New Zealand Dental Journal, 118(1), 15-24.
Journal - Research Article
Chutipongpisit, K., Parachuru, V. P., Friedlander, L. T., Hussaini, H. M., & Rich, A. M. (2021). Immunohistochemical and immunofluorescence expression profile of lymphatic endothelial cell markers in oral cancer. International Journal of Experimental Pathology, 102, 268-278. doi: 10.1111/iep.12411
Journal - Research Article
Ngah, N. A., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., Ratnayake, J., Cooper, P. R., & Hussaini, H. M. (2021). Lyophilised platelet-rich fibrin: Physical and biological characterisation. Molecules, 26(23), 7131. doi: 10.3390/molecules26237131
Journal - Research Article
Seo, B., Hussaini, H., & Rich, A. M. (2021). The effect of the COVID-19 pandemic lockdown on the oral and maxillofacial pathology diagnostic services in New Zealand. New Zealand Dental Journal, 117(2), 67-72.
Journal - Research Article
Berryman, Z., Bridger, L., Hussaini, H. M., Rich, A. M., Atieh, M., & Tawse-Smith, A. (2020). Titanium particles: An emerging risk factor for peri-implant bone loss. Saudi Dental Journal, 32, 283-292. doi: 10.1016/j.sdentj.2019.09.008
Journal - Research Article
Choi, J. J. E., Zwirner, J., Ramani, R. S., Ma, S., Hussaini, H. M., Waddell, J. N., & Hammer, N. (2020). Mechanical properties of human oral mucosa tissues are site dependent: A combined biomechanical, histological and ultrastructural approach. Clinical & Experimental Dental Research, 6, 602-611. doi: 10.1002/cre2.305
Journal - Research Article
Guan, G., Mei, L., Polonowita, A., Hussaini, H., Seo, B., & Rich, A. M. (2020). Malignant transformation in oral lichen planus and lichenoid lesions: A 14-year longitudinal cohort study of 829 patients in New Zealand. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology, 130(4), 411-418. doi: 10.1016/j.oooo.2020.07.002
Journal - Research Article
McElroy, K. E., Seo, B. L., Hussaini, H. M., & Rich, A. M. (2020). Graft versus host disease: Cases from New Zealand with oral manifestations. New Zealand Dental Journal, 116(2), 47-54.
Journal - Research Article
Yu, Z., Seo, B., Hussaini, H. M., Meldrum, A. M., & Rich, A. M. (2020). The relative frequency of paediatric oral and maxillofacial pathology in New Zealand: A 10-year review of a national specialist centre. International Journal of Paediatric Dentistry, 30, 209-215. doi: 10.1111/ipd.12590
Journal - Research Article
Al-Hassiny, A., Friedlander, L. T., Parachuru, V. P. B., Seo, B., Hussaini, H. M., & Rich, A. M. (2018). Upregulation of angiogenesis in oral lichen planus. Journal of Oral Pathology & Medicine, 47(2), 173-178. doi: 10.1111/jop.12665
Journal - Research Article
Chher, T., Hak, S., Kallarakkal, T. G., Durward, C., Ramanathan, A., Ghani, W. M. N., … Hussaini, H. M., & Zain, R. B. (2018). Prevalence of oral cancer, oral potentially malignant disorders and other oral mucosal lesions in Cambodia. Ethnicity & Health, 23(1), 1-15. doi: 10.1080/13557858.2016.1246431
Journal - Research Article
Mohamed, A. M., Hung, W. K., Jen, L. W., Nor, M. M., Hussaini, H. M., & Rosli, T. I. (2018). In vitro study of white spot lesion: Maxilla and mandibular teeth. Saudi Dental Journal, 30, 142-150. doi: 10.1016/j.sdentj.2017.12.001
Journal - Research Article
Hussaini, H. M., Parachuru, V. P. B., Seymour, G. J., & Rich, A. M. (2017). Forkhead box-P3+ regulatory T cells and toll-like receptor 2 co-expression in oral squamous cell carcinoma. Acta Histochemica, 119(3), 205-210. doi: 10.1016/j.acthis.2016.12.005
Journal - Research Article
Kanagasingam, S., Hussaini, H. M., Soo, I., Baharin, S., Ashar, A., & Patel, S. (2017). Accuracy of single and parallax film and digital periapical radiographs in diagnosing apical periodontitis: A cadaver study. International Endodontic Journal, 50(5), 427-436. doi: 10.1111/iej.12651
Journal - Research Article
Saleh, A., Kong, Y. H., Haron, N., Aripin, S. F., Vadiveloo, M., Hussaini, H., … Cheong, S. C. (2017). Oral cancer screening in private dental practices in a developing country: Opportunities and challenges. Community Dentistry & Oral Epidemiology, 45(2), 112-119. doi: 10.1111/cdoe.12266
Journal - Research Article
Seo, B., Hussaini, H. M., & Rich, A. M. (2017). Second opinion oral pathology referrals in New Zealand. Pathology, 49(3), 277-284. doi: 10.1016/j.pathol.2016.11.007
Journal - Research Article
Friedlander, L. T., Hussaini, H., Cullinan, M. P., Seymour, G. J., De Silva, R. K., De Silva, H., Cameron, C., & Rich, A. M. (2015). VEGF and VEGFR2 in dentigerous cysts associated with impacted third molars. Pathology, 47(5), 446-451. doi: 10.1097/pat.0000000000000272
Journal - Research Article
Parachuru, V. P. B., Coates, D. E., Milne, T. J., Hussaini, H. M., Rich, A. M., & Seymour, G. J. (2014). Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease. Journal of Periodontal Research, 49(6), 817-826. doi: 10.1111/jre.12169
Journal - Research Article
Rich, A. M., Hussaini, H. M., Parachuru, V. P. B., & Seymour, G. J. (2014). Toll-like receptors and cancer, particularly oral squamous cell carcinoma. Frontiers in Immunology, 5, 464. doi: 10.3389/fimmu.2014.00464
Journal - Research Article
Sinon, S. H., Rich, A. M., Hussaini, H. M., Yoon, H.-S., Firth, N. A., & Seymour, G. J. (2013). Metastases to the oral region from pleural mesothelioma: Clinicopathologic review. Head & Neck, 35(4), 599-604. doi: 10.1002/hed.21942
Journal - Research Article
Hussaini, H. M., Angel, C. M., Speight, P. M., Firth, N. A., & Rich, A. M. (2012). A double-clear variant of epithelial-myoepithelial carcinoma of the parotid gland. Head & Neck Pathology, 6(4), 471-475. doi: 10.1007/s12105-012-0350-y
Journal - Research Article
Hussaini, H. M., Waddell, J. N., Girvan, L., West, L. M., Kardos, T. B., Rich, A. M., & Seymour, G. J. (2011). Silver solder ″tattoo,″: A novel form of oral pigmentation identified with the use of field emission scanning electron microscopy and electron dispersive spectrography. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology, 112(4), e6-e10. doi: 10.1016/j.tripleo.2011.03.049
Journal - Research Article
Ng, L. K., Rich, A. M., Hussaini, H. M., Thomson, W. M., Fisher, A. L., Horne, L. S., & Seymour, G. J. (2011). Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. British Journal of Cancer, 104(3), 460-463. doi: 10.1038/sj.bjc.6606057
Journal - Research Article
Mohd Bakri, M., Hussaini, H. M., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2010). Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. Journal of Oral Microbiology, 2, 5780. doi: 10.3402/jom.v2i0.5780
Journal - Research Article
Rich, A. M., Hussaini, H. M., Mohd Nizar, M. A., Gavidi, R. O., Tauati-Williams, E., Yakin, M., & Seo, B. (2023). Diagnosis of oral potentially malignant disorders: Overview and experience in Oceania. Frontiers in Oral Health, 4, 1122497. doi: 10.3389/froh.2023.1122497
Journal - Research Other
Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684
Journal - Research Other
Goh, R., Tawse-Smith, A., Reid, I. P., Hussaini, H. M., & Seo, B. (2022). Fibrous epulis with ossification: A case report and review of the literature. Brazilian Journal of Periodontology, 31(3), 73-81. doi: 10.14436/0103-9393.31.3.073-081.oar
Journal - Research Other
Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for vital pulp treatment. International Endodontic Journal, 54, 1263-1274. doi: 10.1111/iej.13524
Journal - Research Other
Ngah, N. A., Ratnayake, J., Cooper, P. R., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., & Hussaini, H. M. (2021). Potential of lyophilized platelet concentrates for craniofacial tissue regenerative therapies. Molecules, 26, 517. doi: 10.3390/molecules26030517
Journal - Research Other
Rich, A. M., Hussaini, H. M., Seo, B., & Zain, R. B. (2020). Understanding the complex microenvironment in oral cancer: The contribution of the Faculty of Dentistry, University of Otago over the last 100 years. Journal of the Royal Society of New Zealand, 50(1), 15-34. doi: 10.1080/03036758.2020.1736586
Journal - Research Other
Amtha, R., Hartanto, F. K., Gautama, W., & Hussaini, H. M. (2019). Pleomorphic rhabdomyosarcoma of the tongue in adult mimicking oral squamous cell carcinoma. Scientific Dental Journal, 3(2), 70-74. doi: 10.4103/SDJ.SDJ_10_19
Journal - Research Other
Yakin, M., Seo, B., Hussaini, H., Rich, A., & Hunter, K. (2019). Human papillomavirus and oral and oropharyngeal carcinoma: The essentials. Australian Dental Journal, 64, 11-18. doi: 10.1111/adj.12652
Journal - Research Other
Hussaini, H. M., Parachuru, V. P. B., Seymour, G. J., & Rich, A. M. (2017). FoxP3 and TLR2 in co-expression in oral cancer. Acta Histochemica, 119(7), 768. doi: 10.1016/j.acthis.2017.06.006
Journal - Research Other
Nasir, S. A., Tan, H. L., Tan, H. J., Hussaini, H. M., & Ramli, R. (2017). Stevens-Johnson Syndrome following failure of genetic screening prior to Carbamazepine prescription. Case Reports in Dentistry, 2017, 4201357. doi: 10.1155/2017/4201357
Journal - Research Other
Rich, A. M., Seo, B., Parachuru, V., & Hussaini, H. M. (2017). The nexus between periodontics and oral pathology. Periodontology 2000, 74(1), 176-181. doi: 10.1111/prd.12197
Journal - Research Other
Tawse-Smith, A., Ma, S., Siddiqi, A., Duncan, W. J., Girvan, L., & Hussaini, H. M. (2012). Titanium particles in peri-implant tissues: Surface analysis and histologic response [Case series]. Clinical Advances in Periodontics, 2(4), 232-238. doi: 10.1902/cap.2012.110081
Journal - Research Other
